DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and AgaP_AGAP008899

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_319646.4	Gene:	AgaP_AGAP008899 / 1279866	VectorBaseID:	AGAP008899	Length:	934	Species:	Anopheles gambiae

Alignment Length:	944	Identity:	211/944 - (22%)
Similarity:	329/944 - (34%)	Gaps:	317/944 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   500 PSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASP--- 561
            |..|.||...|..|:|..    .|.::..:.:.     .||||...:.....|:  .|..||
Mosquito    68 PDCAMYENEHNGGLKQTV----FGCKLIFARSG-----ILRRTPYCVTLQAVDQ--TVEYSPYHY 121

  Fly   562 --APLTQLTAA-----VLTNTNNNHIYADLELDKKKDTS------------PSPECKGE------ 601
              ...|:.|||     :.||.|..|.| ||.......:|            ||...:|.
Mosquito   122 EATATTRDTAANASICLTTNLNRIHEY-DLPQPAALTSSGNVHQAAAAAAPPSFYAEGSGFPANP 185

  Fly   602 -QIQPKKEQIRIEIN----QTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAI------- 654
             :|...||.|..:.:    :.|..|:: |.|  |.|.:..|:.||     .|:.:||.
Mosquito   186 ARIVYPKEAIVYDTSRKFARIAEPNAL-AQL--IQENSADLNFRL-----VSNPLNAFGITKIAG 242

  Fly   655 ------ESAEENHIQTR----------------KLAKDPD-------------------SQTKRS 678
                  |:|.:|..::|                :|.|:||                   :...|:
Mosquito   243 IIYLKNETAFQNKPESRHELTVAWKNYTVSILVRLRKNPDGVHCAAVPPGPDSAEDFCAAHPNRT 307

  Fly   679 SSSSS----------ECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMG---KNHIL 730
            |...:          |.||..|...............:|:....:.:    ||..||   |.||.
Mosquito   308 SCEGACGLGSLKGPCEYRSQTDLPGLWTEDYPTCSSGLSHCPDGVCD----PLEEMGHREKIHIC 368

  Fly   731 NEEQDAKRTQPSQHHHSSGSDCPTNS---SSSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTI 792
            .::...|:.....||........|.|   |..:|.:.:........::...|::|..:|| |||.
Mosquito   369 PQDCVYKQDIVGLHHSDKARGIQTASGHCSCRASGHCSCIDTLRIPASFKRSKTTTSSST-TTTT 432

  Fly   793 TTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFD 857
            ||:||||||.:
Mosquito   433 TTSTTTTPSYD------------------------------------------------------ 443

  Fly   858 FAKEFEVEQPAGSAADEQFCNCPPAGQKP---VKPSVQISGHKDHPFESSSGELDENSDRDIDND 919
                                 .|||..:.   .:|.:....|
Mosquito   444 ---------------------APPAAVRDGSLYEPGLITGPH----------------------- 464

  Fly   920 EEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRE 984
                  ||..::::    ..:|.:.|.:.:     ||       ...|:..|:....||......
Mosquito   465 ------ASIYLIAI----VLIPMVVAVMIV-----LY-------CFSRKLTVKNKLLDGSSGANG 507

  Fly   985 TIRNEESQIVLSVCW-NGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILR 1048
            ||  ..|.|:|   | :.|.||                       ...||.|
Mosquito   508 TI--GASIIIL---WIDFHFHF-----------------------TFSQYDS------------- 531

  Fly  1049 RPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKL-------DVAVKTCRMTLPDEQKRKF 1106
                  :||....:::|...:|.|.||.|.|.  .:|.|       .||||..:......:....
Mosquito   532 ------KWEFPRTNLILDATLGEGEFGKVLKG--FATDLPEKPGITTVAVKMLKTGANSVELLAL 588

  Fly  1107 LQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR------------KNS-NGLT 1158
            |.|.::|::.:|||:::|:|.|.:....::::|....|||..|||            :|: ..:|
Mosquito   589 LSEYQLLQEVNHPNVIRLLGACTKGDSPLLIIEYCQYGSLKNYLRLSRKLEVLNADYENAVEPIT 653

  Fly  1159 TRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQ 1221
            .:..:......:.||.||.....:||||||||.|:......||||||::|:  |::..:.....:
Mosquito   654 VKDILSFAWQISKGMAYLTDIKLVHRDLAARNVLLAEGKVCKISDFGLTRDVYEDDAYLKKSKDR 718

  Fly  1222 IPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTP 1286
            :||||.|||:|....||:..|||::|:|.||:.:.|.:||.|:........:..||||..||:..
Mosquito   719 VPVKWMAPESLADHIYTTKSDVWAFGVLCWELITLGASPYPGIPPQNLYNLLKQGYRMECPKNCS 783

  Fly  1287 EEMYRLMLQCWAADAESRPHFDEIYNVVDALILR 1320
            ||:|.::..|||.|.:.||.|..:....:.|:.|
Mosquito   784 EEIYGIVRLCWADDPKQRPSFKHLAGQFELLLGR 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/86 (21%)
		TyrKc	1063..1311	CDD:197581	89/269 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	88/269 (33%)
AgaP_AGAP008899	XP_319646.4	PKc_like	539..818	CDD:304357	91/281 (32%)
AgaP_AGAP008899	XP_319646.4	Pkinase_Tyr	540..811	CDD:285015	89/272 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910