Protein Alignment FER and Csk

DIOPT Version :10

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_061501935.1
• Gene: Csk / 1278803
• VectorBaseID: AGAMI1_000696
• Length: 1254
• Species: Anopheles gambiae
• Alignment Length: 1307
• Identity: 292/1307 - (22%)
• Similarity: 459/1307 - (35%)
• Gaps: 404/1307 - (30%)

  Fly   320 GAVRDCQEKQMKMI--EHVNGGS-------PVANGSIISNGS-----NTSNGIQSNKDSLCRQSK 370
            |:.|..|:::.:::  |:..|.:       |.|.|: :.|||     :.:.|..:|.:.  :..:
Mosquito    27 GSARLQQQERQELLTGENTLGSTALGEANLPSAEGT-VRNGSLDLVDSGAGGNDTNNNH--KGYR 88

  Fly   371 DLNALRCQEKQKQKLVDMIKCALNE------VGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNS 429
            :.|..|.|..:....:.|......|      .|..|:.||..|| ||          .|...|..
Mosquito    89 NFNHRRYQSDEGPGFIGMRNGKPPERADGASPGSSEVVSGESDD-TL----------GEPDPSRK 142

  Fly   430 TSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQS------- 487
            .....:..:|.....||.| |..|.|:            .|...:...:|..:|::.|
Mosquito   143 RDKFTISFLNTHRSSGGGL-LPNGGGK------------SMLNHKFIVYNSKKPKTSSVLHQQYY 194

  Fly   488 ------------LGSLSVIRDGNG----PSPARYEPITNHRLRQAASVHYLGE-----EIATSST 531
                        |||     .|:|    |.|:.|:....:|||.:.|...|..     ..|..|.
Mosquito   195 QQSIAAAAANGELGS-----SGSGSPPLPYPSHYQQYLYNRLRPSLSTSVLSSPSLITAAAIPSC 254

  Fly   532 NPPDLTRLRRTQ-----------------CSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNH 579
            :|||..||.:.|                 .|:|.......|....|.:.|...:||..::.....
Mosquito   255 SPPDRDRLEQQQQQQQHQLYQNSLFHQQHRSLLGTPPAAVPGWAKSTSCLVSSSAAAASSYRTVT 319

  Fly   580 IYADLELDKKKDTS---PSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRL 641
            ....|.|..:...|   |.|...|...:|            .|.:|.::.|..       .....
Mosquito   320 ASPLLLLPAQPARSAPQPYPSAGGTAPRP------------VPASSSNSSLSS-------SPSSF 365

  Fly   642 KRTLQPSDDVNA-------------IESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSH 693
            .....||...|:             :.:...|.:..        :.|...||.::...:|.|.|:
Mosquito   366 SAGSPPSSGANSSSNTPPPPVVPSEVTATSANAVTA--------TSTTTCSSPTTPTTTSPDASN 422

  Fly   694 S----------------KKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKR---- 738
            |                ...|.|.|..::....|.:..|.:|   ....:.::..:|..||
Mosquito   423 SPTPVPPTGTVAPSTPTHPSSPSSSTSNLDVDVSGVPRFDRS---TKPASSVIGSDQYQKRFHHQ 484

  Fly   739 -TQPSQH-----HHSSGSD-------------CPTNSSSSSSNNNNNNKNTSSNS---------- 774
             .||.|.     |..|..|             ...||:.||...|..|.:|::.:
Mosquito   485 QQQPQQRSFDLPHSESVCDHRQQEEAEDSSLVARRNSTGSSVALNGMNSHTAAINLQHPGTGQTA 549

  Fly   775 ---NHSASQSTIITSTITTTITTTTT--------------TTPSKENSR---------------- 806
               :|....||::.:..:...:.:.|              |.|::::.|
Mosquito   550 VVGHHRGFSSTVVAAANSAAASASATDCPWFLPHQMPPPPTAPARQHKRPAPQPGGATVVGGGGG 614

  Fly   807 ------------LKFKVP------KIQKKSKAIRNTFRSKLLN--------------------FQ 833
                        .:|..|      :.|::....:::.:|.::.                    .|
Mosquito   615 GGGGGPGNHMQPPQFISPPPAPQQQQQQQQHQQQHSQQSAIVPPPQLPPHSVNPSLSSIHHPVQQ 679

  Fly   834 LKRSKPCKQCTKRRRIHPSKSVFDF----AKEFEVEQPAGSAA-----------------DEQFC 877
            |...:..:|...:..|.|..:|...    ..:....|||.:..                 :....
Mosquito   680 LVAPQSAQQQPHQPPIPPHPAVQHHIPKSPNQHHPPQPASAVLQHNPQAASAVGGGVLTNNSHHT 744

  Fly   878 NCPP---AGQKPVKP---------------SVQISGHKDHPFESSSGELDENSDRDIDNDEEEED 924
            ..||   ||..||.|               |.|:.||...|....:|     |...|...::::.
Mosquito   745 TGPPSTGAGGPPVAPVTGSAAANMMSTSMNSAQLQGHILQPVGGLTG-----SALSIHQQQQQQQ 804

  Fly   925 SAS------DDVLSMKDHCY-----------------------------CVP----------SLA 944
            ..|      ..|..|.:..:                             |||          :.|
Mosquito   805 QQSAMVQGNQPVHHMSNSLHGPIGLPTVVVPPAGHDGSNGVGGPAPGWNCVPVGLSSPTTSAAAA 869

  Fly   945 ASISLSTNRPLYEEEWFHGVLPREEVVRLL--NNDGDFLVRETIRNEESQIVLSVCWNGH-KHFI 1006
            |......|..|....||||.:.|||...||  ..||.|||||: .|......|.||:|.. :|:.
Mosquito   870 AQRRAEVNAKLNAMPWFHGRIKREEAESLLKPREDGLFLVRES-TNFPGDYTLCVCFNEKVEHYR 933

  Fly  1007 VQ------TTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAI---LRRPVCRER------- 1055
            ::      |..:..:      |..:.:|:.|       .|:.|..:   |.:.:.:|.
Mosquito   934 IKYVDNKLTIDDDEY------FDHLGQLVEH-------YTLDSDGLCTKLMKALPKEEFCVKDFQ 985

  Fly  1056 ---WELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPD--EQKRKFLQEGRILKQ 1115
               ||:..:|:.|.|.||:|.||||....:|..|  ||||    .|.|  ....|||.|..::..
Mosquito   986 DNGWEIKMEDLQLKENIGKGEFGDVMLGIMKGEK--VAVK----VLKDAGRASNKFLAEAGVMTT 1044

  Fly  1116 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR-KNSNGLTTRQQMGMCRDAAAGMRYLESK 1179
            .:|.|:||.||:....:.|.:|.|.:..|||:.||| :....::.:.|:....|...||.|||:|
Mosquito  1045 LEHENLVKFIGLVFHDKYIYLVTEYMSKGSLVDYLRSRGRQHISRKDQINFAYDTCCGMEYLETK 1109

  Fly  1180 NCIHRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVW 1244
            ..|||||||||.|:..:...|:||||::|:|.  ...|..| :|:||||||||..||:::..|:|
Mosquito  1110 KVIHRDLAARNVLISEDCVAKVSDFGLARDER--YTGDSSK-LPIKWTAPEALKEGKFSNKTDMW 1171

  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDE 1309
            |:|||:|||:|.|..||..:..:...:.:.:||:|..|:..|.|:|.:|.|.|....|.||.|.|
Mosquito  1172 SFGILLWEIYSFGRVPYPRIPLADVVKHVGSGYKMEAPEGCPPEIYEMMRQAWDLVPEKRPTFAE 1236

  Fly  1310 ----IYN 1312
                :||
Mosquito  1237 LKRRLYN 1243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/94 (29%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/253 (41%)
Csk	XP_061501935.1	None