Protein Alignment FER and AgaP_AGAP003986

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_003436676.1
• Gene: AgaP_AGAP003986 / 1278803
• VectorBaseID: AGAP003986
• Length: 1143
• Species: Anopheles gambiae
• Alignment Length: 1224
• Identity: 275/1224 - (22%)
• Similarity: 434/1224 - (35%)
• Gaps: 349/1224 - (28%)

  Fly   320 GAVRDCQEKQMKMI--EHVNGGS-------PVANGSIISNGS-----NTSNGIQSNKDSLCRQSK 370
            |:.|..|:::.:::  |:..|.:       |.|.|: :.|||     :.:.|..:|.:.  :..:
Mosquito    27 GSARLQQQERQELLTGENTLGSTALGEANLPSAEGT-VRNGSLDLVDSGAGGNDTNNNH--KGYR 88

  Fly   371 DLNALRCQEKQKQKLVDMIKCALNE------VGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNS 429
            :.|..|.|..:....:.|......|      .|..|:.||..|| ||          .|...|..
Mosquito    89 NFNHRRYQSDEGPGFIGMRNGKPPERADGASPGSSEVVSGESDD-TL----------GEPDPSRK 142

  Fly   430 TSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQS------- 487
            .....:..:|.....||.| |..|.|:            .|...:...:|..:|::.|
Mosquito   143 RDKFTISFLNTHRSSGGGL-LPNGGGK------------SMLNHKFIVYNSKKPKTSSVLHQQYY 194

  Fly   488 ------------LGSLSVIRDGNG----PSPARYEPITNHRLRQAASVHYLGE-----EIATSST 531
                        |||     .|:|    |.|:.|:....:|||.:.|...|..     ..|..|.
Mosquito   195 QQSIAAAAANGELGS-----SGSGSPPLPYPSHYQQYLYNRLRPSLSTSVLSSPSLITAAAIPSC 254

  Fly   532 NPPDLTRLRRTQ----------------CSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHI 580
            :|||..||.:.|                .|:|.......|....|.:.|...:||..::
Mosquito   255 SPPDRDRLEQQQQQQHQLYQNSLFHQQHRSLLGTPPAAVPGWAKSTSCLVSSSAAAASS------ 313

  Fly   581 YADLELDKKKDTSPSPECKGEQIQPKKEQIRIE-----INQTAPQNSIDAHLDRIDELNRVLDDR 640
            |..:...........|.....|..|....:.:.     ...|.|.:|:...    |:..:....:
Mosquito   314 YRTVTASPLLLLPAQPARSAPQPYPAAGDVDVSGVPRFDRSTKPASSVIGS----DQYQKRFHHQ 374

  Fly   641 LKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLSFSQKS 705
            .::..|.|.|:...||..::..|..  |:|.....:|:|:.||...:..: ||:...:|......
Mosquito   375 QQQPQQRSFDLPHSESVCDHRQQEE--AEDSSLVARRNSTGSSVALNGMN-SHTAAINLQHPGTG 436

  Fly   706 ISNIFSNLKEFS--------------------------------------KSPLVRMGKNHILN- 731
            .:.:..:.:.||                                      |.|..:.|...::.
Mosquito   437 QTAVVGHHRGFSSTVVAAANSAAASASATDCPWFLPHQMPPPPTAPARQHKRPAPQPGGASVVGG 501

  Fly   732 ------------------------EEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSS 772
                                    .:|..::.|..|.|....:..|......      :|.|.|.
Mosquito   502 GGGGGGGGPGSHMQPPQFISPPPAPQQQQQQQQHQQQHSQQSAIVPPPQLPP------HNVNPSL 560

  Fly   773 NSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRS 837
            :|.|...|..:...    :........|...:..::..:||...:.
Mosquito   561 SSIHHPVQQLVAPQ----SAQQQPHQPPIPPHPAVQHHIPKSPNQH------------------- 602

  Fly   838 KPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAA--------DEQFCNCPP---AGQKPVKP-- 889
                        ||.:.    |.......|..::|        :......||   ||..||.|
Mosquito   603 ------------HPPQP----ASAVLQHNPQAASAVGGGVLTNNSHHTTGPPSTGAGGPPVAPVT 651

  Fly   890 -------------SVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSA-----SDDVLSMKDH 936
                         |.|:.||...|....:|     |...|...::::..:     :..|..|.:.
Mosquito   652 GSAAANMMSTSMNSAQLQGHILQPVGGLTG-----SALSIHQQQQQQQQSAMVQGNQPVHHMSNS 711

  Fly   937 CY-----------------------------CVP----------SLAASISLSTNRPLYEEEWFH 962
            .:                             |||          :.||......|..|....|||
Mosquito   712 LHGPIGLPTVVVPPAGHDGSNGVGGPAPGWNCVPVGLSSPTTSAAAAAQRRAEVNAKLNAMPWFH 776

  Fly   963 GVLPREEVVRLL--NNDGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQ------TTGEGNFRFE 1018
            |.:.|||...||  ..||.|||||: .|......|.||:|.. :|:.::      |..:..:
Mosquito   777 GRIKREEAESLLKPREDGLFLVRES-TNFPGDYTLCVCFNEKVEHYRIKYVDNKLTIDDDEY--- 837

  Fly  1019 GPPFASIQELIMHQYHSELPVTVKSGAI---LRRPVCRER----------WELSNDDVVLLERIG 1070
               |..:.:|:.|       .|:.|..:   |.:.:.:|.          ||:..:|:.|.|.||
Mosquito   838 ---FDHLGQLVEH-------YTLDSDGLCTKLMKALPKEEFCVKDFQDNGWEIKMEDLQLKENIG 892

  Fly  1071 RGNFGDVYKAKLKSTKLDVAVKTCRMTLPD--EQKRKFLQEGRILKQYDHPNIVKLIGICVQKQP 1133
            :|.||||....:|..|  ||||    .|.|  ....|||.|..::...:|.|:||.||:....:.
Mosquito   893 KGEFGDVMLGIMKGEK--VAVK----VLKDAGRASNKFLAEAGVMTTLEHENLVKFIGLVFHDKY 951

  Fly  1134 IMIVMELVLGGSLLTYLR-KNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEH 1197
            |.:|.|.:..|||:.||| :....::.:.|:....|...||.|||:|..|||||||||.|:..:.
Mosquito   952 IYLVTEYMSKGSLVDYLRSRGRQHISRKDQINFAYDTCCGMEYLETKKVIHRDLAARNVLISEDC 1016

  Fly  1198 SVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYS 1262
            ..|:||||::|:|.  ...|..| :|:||||||||..||:::..|:||:|||:|||:|.|..||.
Mosquito  1017 VAKVSDFGLARDER--YTGDSSK-LPIKWTAPEALKEGKFSNKTDMWSFGILLWEIYSFGRVPYP 1078

  Fly  1263 GMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDE----IYN 1312
            .:..:...:.:.:||:|..|:..|.|:|.:|.|.|....|.||.|.|    :||
Mosquito  1079 RIPLADVVKHVGSGYKMEAPEGCPPEIYEMMRQAWDLVPEKRPTFAELKRRLYN 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/94 (29%)
		TyrKc	1063..1311	CDD:197581	102/254 (40%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/253 (41%)
AgaP_AGAP003986	XP_003436676.1	SH2_csk_like	770..866	CDD:198190	29/109 (27%)
		PTKc_Csk_like	878..1132	CDD:270635	105/262 (40%)
		STYKc	885..1130	CDD:214568	102/253 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920