DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and AgaP_AGAP008317

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_317149.4	Gene:	AgaP_AGAP008317 / 1277670	VectorBaseID:	AGAP008317	Length:	599	Species:	Anopheles gambiae

Alignment Length:	686	Identity:	182/686 - (26%)
Similarity:	303/686 - (44%)	Gaps:	168/686 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   675 TKRSSSSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHIL-NEEQDAKR 738
            |....|:..:|..|....:| .||.|.::.|.::     :.||.|.|.|:....:| ....|:.:
Mosquito    37 TLNFGSNKGKCTGSSPAQNS-TRSTSPNRASFAS-----RIFSLSLLERLLPGSLLGGGPGDSGK 95

  Fly   739 TQPSQHHHSSGSDCPTNSS--SSSSNNNNNNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPS 801
            .:...|...||...||.:|  ::|.|....:.|...:.|....          .|:|..|..|.:
Mosquito    96 GEIFSHDFISGWASPTVNSFKTASLNGVGLHVNGGGDLNMPGG----------PTVTPGTPNTKA 150

  Fly   802 KENS-RLKFKVPKIQKKSKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVE 865
            |:.| |:|..|                                    .::|.|::
Mosquito   151 KDVSPRVKIVV------------------------------------ALYPFKAI---------- 169

  Fly   866 QPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDV 930
                                                ||....|::|::.::.:|.:|
Mosquito   170 ------------------------------------ESGDLSLEKNAEYEVIDDSQE-------- 190

  Fly   931 LSMKDHCYCVPSLAASISLSTNRPLYEEE--------WFHGVLPREEVVRLL---NNDGDFLVRE 984
                 |.:.|.....:|....:..:.|:|        |:.|.:.|:....||   :.:|.|:||:
Mosquito   191 -----HWWKVKDQHGTIGYIPSNYVKEKELLGLQKYDWYVGDMSRQRAESLLKQNDKEGCFVVRK 250

  Fly   985 TIRNEESQIVLSVCWNGH--------KHFIVQTTGEGNFRF-EGPPFASIQELIMHQYHSE--LP 1038
            :  :.:....||:    |        ||:.::......|.. |.....:|.:||.:..|:.  |.
Mosquito   251 S--STKGLYTLSL----HTKVPQSHVKHYHIKQNARSEFYLSEKHCCETIPDLINYHRHNSGGLA 309

  Fly  1039 VTVKSGAILRRPV------CRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRM- 1096
            ..:|:.. ..|||      ..::||:...::::||.:|.|.||.|.:||.:.: :|.|||..::
Mosquito   310 CRLKTSP-CDRPVPPTAGLSHDKWEIHPSELMILEELGSGQFGVVRRAKWRGS-IDTAVKMMKVG 372

  Fly  1097 TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQ 1161
            |:.::.   |::|.:::.:..|||:|:|.|:|.:.:||.|:.|.:..||||.|||::...|.  .
Mosquito   373 TMSEDD---FIEEAKVMTKLQHPNLVQLYGVCSKHRPIYIITEYMKHGSLLNYLRRHEQSLI--G 432

  Fly  1162 QMG----MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMK 1220
            .||    ||.....||.|||..|.||||||||||||..|::||::|||::|.  :::|..|.|.|
Mosquito   433 NMGLLLDMCIQVCKGMSYLERHNYIHRDLAARNCLVGSENTVKVADFGLARYVLDDQYTSSGGTK 497

  Fly  1221 QIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKST 1285
             .|:||..||.||:.:::|..|||:||:||||:|:.|..||..:.|:...||:..|..:..||:.
Mosquito   498 -FPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEVFTCGKMPYGRLKNTEVVERVQRGIILEKPKAC 561

  Fly  1286 PEEMYRLMLQCWAADAESRPHF----DEIYNVVDAL 1317
            .:|:|.:|.:||:...|.||.|    |::..|...|
Mosquito   562 AKEIYDVMKKCWSHSPEDRPGFRILKDQLAAVAQGL 597

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/107 (21%)
		TyrKc	1063..1311	CDD:197581	105/258 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/258 (41%)
AgaP_AGAP008317	XP_317149.4	SH3_Tec_like	159..212	CDD:212702	12/147 (8%)
		SH2_Tec_family	216..318	CDD:198188	22/108 (20%)
		PTKc_Tec_like	334..591	CDD:173637	105/263 (40%)
		Pkinase_Tyr	339..590	CDD:285015	105/257 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920