DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and AgaP_AGAP006510

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_316537.2	Gene:	AgaP_AGAP006510 / 1277104	VectorBaseID:	AGAP006510	Length:	538	Species:	Anopheles gambiae

Alignment Length:	491	Identity:	163/491 - (33%)
Similarity:	244/491 - (49%)	Gaps:	67/491 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   869 GSAADEQFCNCPPAGQ--KPVKPSVQI---------SGHKDHPFESSSGELDENSDRDI-----D 917
            |.:.|.::...|..||  |..|..|.|         .||.......:....:...:.|:     |
Mosquito    42 GGSIDSRYTPDPNRGQLIKHPKGGVDIIRPRTTPLLPGHNTRRIVVALYNYNAREETDVSFVKGD 106

  Fly   918 NDEEEEDSASD--DVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL----NN 976
            ..|..:|:.||  .|:.:|..   ...|.....::.:|.:..|:||...:.|:|..:||    |.
Mosquito   107 RMEVLDDTESDWWRVVHLKTR---QEGLIPWNFVAEDRSVNSEDWFFENVSRKEADKLLLANENP 168

  Fly   977 DGDFLVRETIRN-----------EESQIVLSVCWNGH--KHFIVQTTGEGNFRF-EGPPFASIQE 1027
            .|.||||.:..|           |||:        |:  ||:.::....|.:.. ....|.|:..
Mosquito   169 RGTFLVRPSEHNPNGFSLSVKDWEESR--------GYHVKHYKIKPLDNGGYYIATNQTFPSLPA 225

  Fly  1028 LIM----------HQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKL 1082
            |:|          |...|..|........| .|..|::||::.:::.|:.::|.||||:||..|.
Mosquito   226 LVMAYSKNALGLCHVLSSPCPKPQPQVWDL-GPELRDKWEINRNEIQLIRKLGHGNFGEVYYGKW 289

  Fly  1083 KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLL 1147
            :: .::|||||.|......|  .||||..|:|::.|..:|.|..:|.:::||.||.|.:..||||
Mosquito   290 RN-NIEVAVKTLREGTMSTQ--AFLQEAAIMKKFRHSRLVALYAVCSKEEPIYIVQEYMSKGSLL 351

  Fly  1148 TYLRK-NSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--E 1209
            .:||. :...|.....:.:....|:||.|||.|..|||||||||.|:...:..||.|||::|  .
Mosquito   352 DFLRTGDGQFLQFEDLIYIAAQVASGMEYLELKQLIHRDLAARNVLIGENNVAKICDFGLARVIA 416

  Fly  1210 EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERID 1274
            ::||....| .:.|||||||||:.:||::...||||||||:.|:|:.|..||.||.:....|:|:
Mosquito   417 DDEYCPKQG-SRFPVKWTAPEAIVYGKFSIKSDVWSYGILLMELFTYGQVPYPGMHSREVIEQIE 480

  Fly  1275 TGYRMPTPKS--TPEEMYRLMLQCWAADAESRPHFD 1308
            .|||||.|.:  .|:::|.|||:||.|..:.||.|:
Mosquito   481 RGYRMPKPTAHHLPDDIYSLMLKCWDAIPDKRPTFE 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/113 (25%)
		TyrKc	1063..1311	CDD:197581	109/251 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	108/247 (44%)
AgaP_AGAP006510	XP_316537.2	SH3_Src_like	85..136	CDD:212779	9/53 (17%)
		SH2_Src_family	144..244	CDD:199827	26/107 (24%)
		STYKc	270..522	CDD:214568	109/251 (43%)
		PTKc_Src_like	274..522	CDD:270630	108/247 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920