DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and AgaP_AGAP006270

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_316335.3	Gene:	AgaP_AGAP006270 / 1276925	VectorBaseID:	AGAP006270	Length:	508	Species:	Anopheles gambiae

Alignment Length:	433	Identity:	147/433 - (33%)
Similarity:	230/433 - (53%)	Gaps:	41/433 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   907 ELDENSDRDIDNDEEE-----EDSASDDVLS----MKDHCYCVPSLAASISLSTNRPLYEEEWFH 962
            :.|..:|.|:...:.|     .|:..|..|:    .:...|...:..|.:     :.:..|.|:.
Mosquito    67 DYDARTDEDLSFRKGEHLEILNDTQGDWWLARSKKTRQEGYIPSNYVAKL-----KSIEAEPWYF 126

  Fly   963 GVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSVCWNGH--KHFIVQTTGEGNFRF-EGP 1020
            ..:.|.|..:.|    |..|.||:|:: .:..:...||| .:|.  ||:.::...||.|.. ...
Mosquito   127 RKIKRIEAEKKLLLPENEHGAFLIRDS-ESRHNDYSLSV-RDGDTVKHYRIRQLDEGGFFIARRT 189

  Fly  1021 PFASIQELIMHQYHSE---LPVTV-KSGAILRRPV-------CRERWELSNDDVVLLERIGRGNF 1074
            .|.::|||:.| |..:   |.|.: |....:.:||       .|::||:....:..:.::|.|.|
Mosquito   190 TFRTLQELVEH-YSKDSDGLCVNLCKPCVQIEKPVTDGLSHRTRDQWEIDRTSLKFVRKLGSGQF 253

  Fly  1075 GDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVME 1139
            |||::....:| ..||:||.:....|  .:.||.|.:|:|:..|..:::|..:|..::||.|:.|
Mosquito   254 GDVWEGLWNNT-TPVAIKTLKSGTMD--PKDFLAEAQIMKKLRHVKLIQLYAVCTLEEPIYIITE 315

  Fly  1140 LVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDF 1204
            |:..||||.||:.....|...|.:.|....||||.||||:|.|||||||||.||...:.|||:||
Mosquito   316 LMKHGSLLDYLQGKGRSLKLPQLIDMAAQIAAGMAYLESQNYIHRDLAARNVLVGDNNIVKIADF 380

  Fly  1205 GMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNS 1267
            |::|  :|:||....|.: .|:|||||||.|:.|::...||||:|||:.|:.:.|..||.||||:
Mosquito   381 GLARLIKEDEYEARVGAR-FPIKWTAPEAANYSKFSIKSDVWSFGILLTELVTYGRIPYPGMTNA 444

  Fly  1268 RARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEI 1310
            ....:::.|||||.|::....:|.:||:||..|...||.|:.:
Mosquito   445 EVLTQVEHGYRMPQPQNCNTPLYEIMLECWNKDPMRRPTFETL 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	26/95 (27%)
		TyrKc	1063..1311	CDD:197581	105/250 (42%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/246 (43%)
AgaP_AGAP006270	XP_316335.3	SH3_Src_like	61..112	CDD:212779	8/44 (18%)
		SH2_Src_Src42	120..215	CDD:198233	27/97 (28%)
		PTKc_Frk_like	233..498	CDD:270653	107/259 (41%)
		Pkinase_Tyr	242..491	CDD:285015	105/250 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.920