DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and AgaP_AGAP005583

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_001688684.1	Gene:	AgaP_AGAP005583 / 1276270	VectorBaseID:	AGAP005583	Length:	915	Species:	Anopheles gambiae

Alignment Length:	966	Identity:	180/966 - (18%)
Similarity:	317/966 - (32%)	Gaps:	296/966 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SSALQSRAAHEALIV-------------RQDAELRLMETMKRSIQMKAKCD--KEYAISLTAVAQ 53
            |:.:.:.||.|..||             :|..:......:..|...:.|||  |.|.:.|   ..
Mosquito    55 SAEMTAAAAAELPIVPAPVNLPVGTDQQQQQQQYNGHNLVNGSFSKQQKCDMCKNYLLGL---VH 116

  Fly    54 QGL---KIDRADEMQGSLI-----SKSWRSYMDELDHQAKQFKFNAEQLEVVCDKLTHLSQDKRK 110
            |||   :.:.....|.|::     |.:......:...|::|   .::|          .||.::.
Mosquito   117 QGLFCTQCNMVVHRQCSVMGLRPCSAAGTQQQQQSQQQSQQ---QSQQ----------QSQQQQP 168

  Fly   111 ARK------------AYQEEHAKIAARLNHLTDEV---------------VRKKSEYQKHLEGYK 148
            .::            ||::||..:..:...|..:|               :.||:...|.|:.|.
Mosquito   169 TQQVGSTTGGYMLGGAYRQEHQHMFGKSLCLLFDVQQQAAPQIVVDLCTSLEKKAVMDKGLDLYV 233

  Fly   149 ALRT---RFEENYIKAPSRSGRKLDDVRDKYQKACRKLHLTHNEYVLSITEAIEVEKDFRNV--- 207
            ..||   |::|            ::.:||...:  ..|::..|.|.......: ::|.|..:
Mosquito   234 VYRTTPLRYDE------------VNKLRDALNE--NLLNIDLNGYTPECVATV-LKKFFHELPDP 283

  Fly   208 LLP----------GLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRIDTVIGSINPT 262
            |:|          .||:.||:|:.     .:.|:||.|.:.:.|...:.....||..:
Mosquito   284 LIPVAWYQSFIDASLLDDQQAVER-----MKGIIQEMAPHHNKTLQYFMRHLIRICRL------- 336

  Fly   263 EEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDN---------LTVDWLRNRLQEL 318
                :|....|..||. ||..:...|::....::......:.|         ..:|| ...|.|.
Mosquito   337 ----QFMRGNKQQPTM-LLQNWCHILMRPAWERIVHFVANIKNHLRVLELLMYKIDW-NEALPEF 395

  Fly   319 ---------------EGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQ 368
                           .||.......:..:|....||| :....:.|:.|.|:.|..|:.::|.|.
Mosquito   396 LSIPAVPPRKTSRTGSGAGTGPGSTKKSIIASPEGGS-IGGPLLESDYSTTTTGSGSSGNTLGRS 459

  Fly   369 S---------------KDLNA---LR---------CQEKQKQKLVD------MIKCALNEVGCEE 400
            :               .|.|.   ||         .::..|:|::|      :::.|:|:.|...
Mosquito   460 AAQQYPNGGGMLMSLITDPNTPQELRDAEWYWGKISRDVAKEKMMDAPDGSFLVRDAINDAGEFT 524

  Fly   401 L---PSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFKRKS 462
            |   ..|.|..:.:.....:.|:..|     .|....:|::||.
Mosquito   525 LVLKKDGTDRPIKIYHKNGKYGFTQE-----CTFESLVGMINEF--------------------- 563

  Fly   463 TPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSP-ARYEPITNHRLRQAA-SVHYLGEE 525
                                 |:.:|...:.|.|.:...| :|:|   :..|..|| .:|.|...
Mosquito   564 ---------------------RTTTLKEYNTILDISLLYPISRFE---DESLYPAAGDIHQLAAS 604

  Fly   526 IATSSTNPPDLTRLRRT--------QCSMLCLGEDEEPVVLASPAPLTQ-LTAAVLTNTNNNHIY 581
            ...:.....||..:|.:        |..|....:.:|..:.|......| ||.|........|..
Mosquito   605 FYETVQKLTDLQNMRESTLEAFNVCQSHMELRRQAQEAFIEADKLFNDQLLTQARYEKEAQPHEQ 669

  Fly   582 ADL------------ELDK-KKDTSPSPECKGE---QIQPKKEQIRIEINQTAPQNSIDAHLDRI 630
            ..|            ||.| ||:.....|.:.|   ::|.:..:::.||...:.|.  |.:|:.:
Mosquito   670 RSLAQNRTLIESRLEELRKCKKNLDEDMERERERMRELQREAMKLKPEIMNLSKQK--DQYLEAL 732

  Fly   631 D-------ELNRVLDDRLKRTLQPS--------DDVNAIESAEENHIQTRKLAKDPDS----QTK 676
            .       ::.::|.|....|..|.        |:...:..........:|||..|..    :.:
Mosquito   733 KRQSITDAQIKQILKDGYLSTANPDGTQELPHLDETTWLRERYSRQDAEKKLANKPTGTFLIRAR 797

  Fly   677 RSS----SSSSECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAK 737
            .:.    |.:.:.|.:....|..:|...|::...  |:.:|    ||.:|....|. |.|..|..
Mosquito   798 NAGHYALSIACDGRVNHCIIHQTERGYGFAEPYY--IYDSL----KSLVVHYATNS-LEEHNDLL 855

  Fly   738 RT----------QPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNH-SASQST 782
            :|          .||.....|||...:.|..:|.........:||:... ||..||
Mosquito   856 QTTLKYPAFAPNMPSGSGSGSGSGSGSGSGQTSGGGGGGGGGSSSSRQQGSAPWST 911

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	58/301 (19%)
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
AgaP_AGAP005583	XP_001688684.1	SAM_superfamily	<9..58	CDD:301707	1/2 (50%)
		C1	91..140	CDD:237996	12/51 (24%)
		RhoGAP	209..>335	CDD:238090	30/145 (21%)
		SH2_nSH2_p85_like	481..589	CDD:198195	24/157 (15%)
		iSH2_PI3K_IA_R	596..747	CDD:214016	28/152 (18%)
		PI3K_P85_iSH2	596..746	CDD:293063	28/151 (19%)
		SH2	763..865	CDD:301589	20/108 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910