Protein Alignment FER and AgaP_AGAP003651

DIOPT Version :9

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_313423.5
• Gene: AgaP_AGAP003651 / 1274321
• VectorBaseID: AGAP003651
• Length: 1542
• Species: Anopheles gambiae
• Alignment Length: 1632
• Identity: 703/1632 - (43%)
• Similarity: 876/1632 - (53%)
• Gaps: 407/1632 - (24%)

  Fly     1 MGFSSALQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYAISLTAVAQQGLKIDRADEMQ 65
            ||||||||.||||:||:.||:|||:|:|||||.:..|||||:|||:||.||.||||||||:|::|
Mosquito     1 MGFSSALQGRAAHDALLNRQEAELKLLETMKRCLAQKAKCDREYAVSLAAVTQQGLKIDRSDDLQ 65

  Fly    66 GSLISKSWRSYMDELDHQAKQFKFNAEQLEVVC-DKLTHLSQDKRKARKAYQEEHAKIAARLNHL 129
            |:.:.::|||:|:||||.|||.:.||||||.|| :||..|.|:||:.||.|||||.|||.:.:||
Mosquito    66 GNHVMRAWRSFMEELDHTAKQIRTNAEQLETVCHEKLASLYQEKRRVRKQYQEEHTKIATQFSHL 130

  Fly   130 TDEVVRKKSEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQKACRKLHLTHNEYVLSI 194
            |::|.||||||||||:.||.||.|||| :||: .|||||||||.|||||||||||..||||||.|
Mosquito   131 TEDVARKKSEYQKHLDYYKLLRGRFEE-HIKS-GRSGRKLDDVIDKYQKACRKLHQAHNEYVLLI 193

  Fly   195 TEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRIDTVIGSI 259
            |||:|||||||.:|||||||||||:||.||..|.|:|||.|...|:|:||:.:||:||::.|..|
Mosquito   194 TEAVEVEKDFRTILLPGLLEHQQSLQEGFIQAWSNLLQEIANLSDMTSDKFVDIQRRIESSIAGI 258

  Fly   260 NPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLTVDWLRNRLQELEGAVRD 324
            |.||||.|||||:|||||.|::|||||:|::|..||||::|||||||||||||.|..||||.::|
Mosquito   259 NSTEEYREFTEKHKTSPTPPVIFQFDESLVEDSLGKLQANTLTVDNLTVDWLRGRQTELEGTIKD 323

  Fly   325 CQEKQMKMIEHVN------GGSPVA----------NGSIISNGSNTSNGIQSNKDSLCRQSKDLN 373
            .|::|.|:....|      |.||.|          ..:.|.|||:||||:.|.:......:..|.
Mosquito   324 LQDRQSKLCGEPNGTNGATGSSPAAVSPASTPGTKPSTPILNGSSTSNGVDSLQQQHTSTAMGLF 388

  Fly   374 ALRCQEKQKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLG-- 436
            :||                                                     |...|.|
Mosquito   389 SLR-----------------------------------------------------TGGGGSGSG 400

  Fly   437 ----IMNELMRRGGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPR--SQSLGSLSVIR 495
                :|::|.|:.|..|:..........:|.|.|........:|..:.:...  |:|:.|..|.|
Mosquito   401 MMSMLMDQLRRKSGPPTVSGSSSAGKTPRSGPTPVQTPKPGHRGATSTVTTNADSESVCSFVVCR 465

  Fly   496 D------GNGPSPARYEPI---------------------TNHRL------RQAASVHYLGEEIA 527
            :      |:..||:..:|.                     ::.||      .:|..:|.|..|.:
Mosquito   466 ERVQAASGDVLSPSASDPTIRPAEAADGATYAELLPARNDSDQRLSNVYVDMEACLLHELDVEQS 530

  Fly   528 TSSTN---------P----------------PDLT-----------RLRRTQCSMLCLGEDEEPV 556
            ...||         |                |:.|           |..||..|    .||.|..
Mosquito   531 FQYTNLSSCGPRQQPLVASAADESFGASCELPNPTNTDHQRHALQYRRLRTHAS----SEDSEVH 591

  Fly   557 VLASPAP--------------------LTQLTAAVLTNTNNNHIYADLELDK------------K 589
            :|....|                    ....|.|...|.:.|::..:...|:            :
Mosquito   592 LLNRQYPCQAADEPGAGEDDDEDDDDGAASCTNADELNDSKNNLLREESFDENQRQQLSNCSTWR 656

  Fly   590 KDTSPSPECKGEQIQPKKEQIRIEINQTAP------QNSIDAHLDRIDELNRVLDD--------- 639
            |.|... |..|:.:..:|| :.|...:..|      ::||:.|||.||.||:.||:
Mosquito   657 KSTEEG-ETDGKYLTMRKE-VAIPAPEALPSQEAQWKSSIERHLDHIDALNQKLDEHQRLAARLS 719

  Fly   640 -----------------------------------------------RLKRTLQPSDDVNAIESA 657
                                                           |:|.|.|.||.......:
Mosquito   720 EEYEYIRVQTLTRPVVAPQPQKPLPGATKPPTQTFEKANSFREKIRRRIKGTKQDSDRQADRSMS 784

  Fly   658 EEN------------------HIQTR-KLAKDPDS---QTKRS------SSSSSECRSSKDTSHS 694
            .:|                  |.|.: :|.||.||   .|.||      ..||:..|..|....|
Mosquito   785 PDNPDQPESFSGRLRSRITAHHTQRQFRLMKDTDSASPSTDRSIAERLPPGSSAAGRKKKKRKAS 849

  Fly   695 KKRSLSFSQKSISNIFSNLKEFSK--SPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSS 757
            |....:..|.|......:..|..:  .|.....::.:|.|||.|...:     ||.|........
Mosquito   850 KANRAARQQLSRGGPDGHQPERHQPLHPQQAFSEDELLAEEQPALSPE-----HSGGPRATAAGG 909

  Fly   758 SSSS-------------NNNNNNKNTSSN-----------------------------------S 774
            ..:|             ::.|..|::|.|                                   .
Mosquito   910 LGTSFSQTVRATWRELIHSTNKVKDSSMNLALRSDRPEEKLDLIAADPDRQGLLSIRFTFSDGGR 974

  Fly   775 NHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPK----------IQKKSKA---IRNTFR 826
            .|......:.:...||............|:::|:...|.          .|:.|||   |::..|
Mosquito   975 KHQLVDGMMASDMHTTADYCVPLLVARSEDTQLQAGSPDGDLRPEPPVFAQRASKAGPSIKSNLR 1039

  Fly   827 SKLLNFQLKRS-----------------KPCKQCTKR--RR--------IHPSKSVFDFAKEFEV 864
            .||.....|::                 :.|:.|:||  :|        :|.|::|.||.|||
Mosquito  1040 DKLTKLVHKKTASGGSVQSGGRWVGAAQEVCRTCSKRIVQRSGSDGGGGMHASRTVLDFRKEF-- 1102

  Fly   865 EQPAGSAADEQFCNCPPAGQKPVKPSVQI--SGHKDHPFESSSGELDENSDRDIDNDEEEEDSAS 927
                                    |.:.|  .|| || .:.::.|:......|||:...|:....
Mosquito  1103 ------------------------PDIDICEGGH-DH-LDGATSEMINLEYEDIDHLNIEQKKKL 1141

  Fly   928 DDVLSMKDHC-YCVPSLAA---SISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRN 988
            .:||:...|. |..||...   :::|||||||:||||||||||||||||||.|:||||||||.||
Mosquito  1142 PNVLAKDTHVPYTFPSTTTTRKNMTLSTNRPLHEEEWFHGVLPREEVVRLLRNEGDFLVRETTRN 1206

  Fly   989 EESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCR 1053
            :|||.|||||||||||||||||.||::|||||.|.||||||:|||.||||||.:|||:||:||.|
Mosquito  1207 DESQTVLSVCWNGHKHFIVQTTAEGHYRFEGPAFPSIQELIVHQYQSELPVTGRSGAVLRKPVLR 1271

  Fly  1054 ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLD-VAVKTCRMTLPDEQKRKFLQEGRILKQYD 1117
            ||||||||||:||::||||||||||||||||:|.. |||||||||||:|||||||||||||||||
Mosquito  1272 ERWELSNDDVILLDKIGRGNFGDVYKAKLKSSKNTLVAVKTCRMTLPEEQKRKFLQEGRILKQYD 1336

  Fly  1118 HPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCI 1182
            ||||||||||||||||||||||||.|||||.:||||::.|..||.||||||||||||||||||||
Mosquito  1337 HPNIVKLIGICVQKQPIMIVMELVAGGSLLMFLRKNASTLGQRQMMGMCRDAAAGMRYLESKNCI 1401

  Fly  1183 HRDLAARNCLVDLEHSVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYG 1247
            ||||||||||:..|:.||||||||||||||||||.||||||:|||||||||||||||||||||||
Mosquito  1402 HRDLAARNCLIGSENIVKISDFGMSREEEEYIVSGGMKQIPIKWTAPEALNFGKYTSLCDVWSYG 1466

  Fly  1248 ILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYN 1312
            ||:|||||:||||||||:||.||||||.|||||.|:..|.|||||||:||:.:.|||||||||.:
Mosquito  1467 ILVWEIFSRGDTPYSGMSNSMARERIDEGYRMPAPEGAPPEMYRLMLKCWSYEPESRPHFDEICS 1531

  Fly  1313 VVDALIL 1319
            |||||:|
Mosquito  1532 VVDALLL 1538

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	161/236 (68%)
		SH2_Fps_family	953..1039	CDD:198224	72/85 (85%)
		TyrKc	1063..1311	CDD:197581	209/248 (84%)
		PTKc_Fes_like	1067..1315	CDD:270637	208/248 (84%)
AgaP_AGAP003651	XP_313423.5	F-BAR_Fes_Fer	7..242	CDD:153341	161/236 (68%)
		SH2_Fps_family	1171..1257	CDD:198224	72/85 (85%)
		Pkinase_Tyr	1281..1529	CDD:285015	208/247 (84%)
		PTKc_Fes_like	1286..1529	CDD:270637	205/242 (85%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	431	1.000	Domainoid score	I1806
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74300
Inparanoid	1	1.050	1156	1.000	Inparanoid score	I667
OMA	1	1.010	-	-		QHG26678
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		oto110766
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1749
TreeFam	0	0.000	Not matched by this tool.
	10	10.170