DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and Ddr1

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:NP_001185760.1 Gene:Ddr1 / 12305 MGIID:99216 Length:911 Species:Mus musculus


Alignment Length:297 Identity:93/297 - (31%)
Similarity:151/297 - (50%) Gaps:46/297 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly  1067 ERIGRGNFGDVYKAKL----------------KSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQ 1115
            |::|.|.||:|:..::                |...|.||||..|.......:..||:|.:|:.:
Mouse   612 EKLGEGQFGEVHLCEVEDPQDLVSSDFPISVHKGHPLLVAVKILRPDATKNARNDFLKEVKIMSR 676

  Fly  1116 YDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYL------RKNSNGLT--TRQQMG-------- 1164
            ...|||::|:|:|||..|:.::.:.:..|.|..:|      .|.:.||:  |....|        
Mouse   677 LKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSARQLENKATQGLSGDTESDQGPTISYPML 741

  Fly  1165 --MCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVK 1225
              :....|:|||||.:.|.:|||||.|||||....::||:||||||.  ..:|....|...:|::
Mouse   742 LHVGAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGMSRNLYAGDYYRVQGRAVLPIR 806

  Fly  1226 WTAPEALNFGKYTSLCDVWSYGILMWEIFSK-GDTPYSGMTNSRARERIDTGYR-------MPTP 1282
            |.|.|.:..||:|:..|||::|:.:||:... ...|:..:|:.:..|.....:|       :..|
Mouse   807 WMAWECILMGKFTTASDVWAFGVTLWEVLMLCRSQPFGQLTDEQVIENAGEFFRDQGRQVYLSRP 871

  Fly  1283 KSTPEEMYRLMLQCWAADAESRPHFDEIYNVV--DAL 1317
            .:.|:.:|.|||:||:.:.|.||.|.:::..:  |||
Mouse   872 PACPQTLYELMLRCWSREPEQRPPFAQLHRFLADDAL 908

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224
TyrKc 1063..1311 CDD:197581 90/287 (31%)
PTKc_Fes_like 1067..1315 CDD:270637 90/293 (31%)
Ddr1NP_001185760.1 FA58C 58..185 CDD:238014
DS-like domain. /evidence=ECO:0000250 193..369
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 468..496
PPxY motif 479..482
PKc_like 602..905 CDD:419665 90/292 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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