DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Btk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_038510.2	Gene:	Btk / 12229	MGIID:	88216	Length:	659	Species:	Mus musculus

Alignment Length:	387	Identity:	134/387 - (34%)
Similarity:	211/387 - (54%)	Gaps:	39/387 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   959 EWFHGVLPREEVVRLL---NNDGDFLVRETIRNEESQIVLSVCWNGH-----KHFIVQTTGEGNF 1015
            ||:...:.|.:..:||   ..:|.|:||::.:..:..:.:.....|.     :|::|.:|.:..:
Mouse   280 EWYSKHMTRSQAEQLLKQEGKEGGFIVRDSSKAGKYTVSVFAKSTGEPQGVIRHYVVCSTPQSQY 344

  Fly  1016 RF-EGPPFASIQELI-MHQYHSELPVTVKSGAI--LRRPVCRER-------------WELSNDDV 1063
            .. |...|::|.||| .||::|       :|.|  |:.||.::.             ||:...|:
Mouse   345 YLAEKHLFSTIPELINYHQHNS-------AGLISRLKYPVSKQNKNAPSTAGLGYGSWEIDPKDL 402

  Fly  1064 VLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGIC 1128
            ..|:.:|.|.||.|...|.:. :.|||:|..|.....|.  :|::|.:::....|..:|:|.|:|
Mouse   403 TFLKELGTGQFGVVKYGKWRG-QYDVAIKMIREGSMSED--EFIEEAKVMMNLSHEKLVQLYGVC 464

  Fly  1129 VQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLV 1193
            .:::||.|:.|.:..|.||.|||:..:...|:|.:.||:|....|.|||||..:|||||||||||
Mouse   465 TKQRPIFIITEYMANGCLLNYLREMRHRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLV 529

  Fly  1194 DLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSK 1256
            :.:..||:||||:||.  ::||..|.|.| .||:|:.||.|.:.|::|..|:|::|:|||||:|.
Mouse   530 NDQGVVKVSDFGLSRYVLDDEYTSSVGSK-FPVRWSPPEVLMYSKFSSKSDIWAFGVLMWEIYSL 593

  Fly  1257 GDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIY-NVVDAL 1317
            |..||...|||...|.|..|.|:..|....|.:|.:|..||...|:.||.|..:. |::|.:
Mouse   594 GKMPYERFTNSETAEHIAQGLRLYRPHLASERVYTIMYSCWHEKADERPSFKILLSNILDVM 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	22/89 (25%)
		TyrKc	1063..1311	CDD:197581	102/249 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	102/250 (41%)
Btk	NP_038510.2	PH_Btk	6..166	CDD:269944
		Inositol-(1,3,4,5)-tetrakisphosphate 1-binding. /evidence=ECO:0000250	12..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..210
		SH3_BTK	217..271	CDD:212839
		SH2_Tec_Btk	274..378	CDD:198260	26/104 (25%)
		PTKc_Btk_Bmx	397..652	CDD:173657	104/258 (40%)
		Inhibitor-binding. /evidence=ECO:0000250	474..479		1/4 (25%)
		CAV1-binding. /evidence=ECO:0000250	581..588		3/6 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910