DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Bmx

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_033889.2	Gene:	Bmx / 12169	MGIID:	1101778	Length:	655	Species:	Mus musculus

Alignment Length:	438	Identity:	150/438 - (34%)
Similarity:	226/438 - (51%)	Gaps:	60/438 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   920 EEEEDSASDDVLSMKDHCYCVPSLA----ASISLSTNRPLYEEEWFHGVLPR---EEVVRLLNND 977
            :.|||.|..:.|......:....::    .|.|......|:..:||.|.:.|   |:::|....:
Mouse   232 KSEEDIACSNQLERNIASHSTSKMSWGFPESSSSEEEENLHAYDWFAGNISRSQSEQLLRQKGKE 296

  Fly   978 GDFLVRETIR-------------NEESQIVLSVCWNGHKHFIVQTTGEGN-FRFEGPPFASIQEL 1028
            |.|:||.:.:             |::...|        ||:.|.|..|.. :..|...|.||.:|
Mouse   297 GAFMVRNSSQMGMYTVSLFSKAVNDKKGTV--------KHYHVHTNAENKLYLAENYCFDSIPKL 353

  Fly  1029 I-MHQYHS----------------ELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGD 1076
            | .||::|                ::||:|..|:.:        |||..:::.||:.:|.|.||.
Mouse   354 IHYHQHNSAGMITRLRHPVSTKANKVPVSVALGSGI--------WELKREEITLLKELGNGQFGV 410

  Fly  1077 VYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELV 1141
            |...:.|. :.|||||..:.....|.  :|.||.:.:.:..||.:||..|:|.:|.||.||.|.:
Mouse   411 VQLGQWKG-QYDVAVKMIKEGAMSED--EFFQEAQTMMKLSHPKLVKFYGVCSKKYPIYIVTEYI 472

  Fly  1142 LGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGM 1206
            ..|.||.||:.:..||.:.|.:.||.|...||.:|||...|||||||||||||.:.|||:|||||
Mouse   473 TNGCLLNYLKSHGKGLESCQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDSDLSVKVSDFGM 537

  Fly  1207 SRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRA 1269
            :|.  :::|:.|.|.| .||||:|||..::.||:|..|||::||||||:||.|..||....||..
Mouse   538 TRYVLDDQYVSSVGTK-FPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPYDLYDNSEV 601

  Fly  1270 RERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDAL 1317
            ..::..|:|:..|:...:.:|::|..||....|.||.|.::.:.::.|
Mouse   602 VVKVSQGHRLYRPQLASDTIYQIMYSCWHELPEKRPTFQQLLSAIEPL 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/119 (23%)
		TyrKc	1063..1311	CDD:197581	108/249 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	106/249 (43%)
Bmx	NP_033889.2	PH_Btk	25..151	CDD:269944
		PH	27..115	CDD:278594
		SH2_Tec_Bmx	269..374	CDD:198262	27/112 (24%)
		PKc_like	392..647	CDD:304357	109/258 (42%)
		Pkinase_Tyr	397..646	CDD:285015	108/252 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910