DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Abl2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_033725.2	Gene:	Abl2 / 11352	MGIID:	87860	Length:	1182	Species:	Mus musculus

Alignment Length:	524	Identity:	160/524 - (30%)
Similarity:	252/524 - (48%)	Gaps:	91/524 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   867 PAGSAAD---------EQFCNCPPAGQKPVK-----PSVQISGHKDHPFESSSGELDE----NSD 913
            |||..||         :.|.:|...|.:..|     |.|.   |:....::.|..|:|    :|.
Mouse    37 PAGRTADAGFNVFTQHDHFASCVEDGFEGDKTGGSSPEVL---HRPFGCDAESQALNEAIRWSSK 98

  Fly   914 RDIDNDEEEED----------SASDDVLSM----------------------KDHCYCVPSLAAS 946
            .::....|.:.          ::.|:.||:                      |:....||    |
Mouse    99 ENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNGQGWVP----S 159

  Fly   947 ISLSTNRPLYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQ 1008
            ..::....|.:..|:||.:.|.....||::  :|.|||||: .:...|:.:|:.:.|. .|:.:.
Mouse   160 NYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRES-ESSPGQLSISLRYEGRVYHYRIN 223

  Fly  1009 TTGEGNFRFEGPP-FASIQELIMHQYHSELPVTVKSGAILR----RPVC-----------RERWE 1057
            ||.:......... |:::.||:.|  ||    ||..|.:..    .|.|           .::||
Mouse   224 TTTDSKVYVTAESRFSTLAELVHH--HS----TVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWE 282

  Fly  1058 LSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNI 1121
            :...|:.:..::|.|.:|:||....|...|.|||||.:. |:..|:   ||:|..::|:..|||:
Mouse   283 MERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEE---FLKEAAVMKEIKHPNL 344

  Fly  1122 VKLIGICVQKQPIMIVMELVLGGSLLTYLRKNS-NGLTTRQQMGMCRDAAAGMRYLESKNCIHRD 1185
            |:|:|:|..:.|..||.|.:..|:||.|||:.| ..:|....:.|....::.|.|||.||.||||
Mouse   345 VQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFIHRD 409

  Fly  1186 LAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGI 1248
            ||||||||...|.||::|||:||  ..:.|....|.| .|:||||||:|.:..::...|||::|:
Mouse   410 LAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNTFSIKSDVWAFGV 473

  Fly  1249 LMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNV 1313
            |:|||.:.|.:||.|:..|:..:.::.||||..|:..|.::|.||..||......||.|.|.:..
Mouse   474 LLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQA 538

  Fly  1314 VDAL 1317
            .:.:
Mouse   539 FETM 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/89 (28%)
		TyrKc	1063..1311	CDD:197581	103/251 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/251 (41%)
Abl2	NP_033725.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..42		3/4 (75%)
		CAP	2..106		16/71 (23%)
		SH3_Abl	111..164	CDD:212784	7/56 (13%)
		SH2_ABL	169..262	CDD:198189	27/99 (27%)
		PTKc_Abl	281..543	CDD:270645	106/266 (40%)
		STYKc	288..539	CDD:214568	103/254 (41%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		9/24 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	612..642
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	655..674
		Nuclear localization signal. /evidence=ECO:0000255	659..661
		F-actin-binding	695..930
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	765..796
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..858
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1059
		F-actin-binding	1020..1182
		FABD	1063..1182	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810