DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and trip10b

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_956518.1	Gene:	trip10b / 108179043	ZFINID:	ZDB-GENE-040426-969	Length:	512	Species:	Danio rerio

Alignment Length:	448	Identity:	79/448 - (17%)
Similarity:	177/448 - (39%)	Gaps:	83/448 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGFSSALQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYAISLTAVAQQGLKIDRADEMQ 65
            |.:.|||..:  |:|:.....:.|.|:|...:.::.:|:.::.|:..|..:.::..:....::..
Zfish     1 MDWGSALWDQ--HDAIERHTQSGLDLLERYMKFVKERAEIEQNYSKQLRNLCKKYTRRGSKEDQD 63

  Fly    66 GSLIS-KSWRSYMDELDHQAKQFKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEHAKIAARLNH 128
            ..|:| :.::..:.:|:..|.|.:..::.|.| :|.:|:....:.|:.||             ||
Zfish    64 TKLVSQQGFQDVLCQLNDYAGQREQLSDSLTVGICVELSRSLTELRQERK-------------NH 115

  Fly   129 LTDEVVRKKSEYQKHLEGYKALRTRFEENYIKA--PSRSGRKLD--------DVRDKYQKACRKL 183
            |. |:.:.:...:...:..::.:.|||:.:.:|  .::...|::        ||....|.|..::
Zfish   116 LA-EIKKAQQNLESSFKQLESSKRRFEKEWKEAEKANQQTEKVEQDASATKADVDKAKQHANVRI 179

  Fly   184 HLT---HNEYVLSITEAIEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKY 245
            |..   .|||...:.:..:.:.::....:|.:.:..|.::|..:.:   :.....|:.|......
Zfish   180 HFADECKNEYASQLQKYNKEQNNYYYADIPFVYKKLQDLEERCVPM---LADGYVQFSDSEKKIL 241

  Fly   246 KEIQKRIDTVIGS---INPTEEYGEFTEKYKTSPTTPLLFQFDETLIQDIPGKLQSSTLTVDNLT 307
            ..|.|.:|::|.|   |:..::.....|:||:....|...:| |...|.:......:|..:..:.
Zfish   242 PNINKCLDSIISSGRRIDEKQDTLALIEQYKSGAVPPADVEF-EDFSQAVKPAAAENTAHLPKVR 305

  Fly   308 VDWL---RNRLQELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQS 369
            :..|   :|::                                    ::....:..:::.|.|..
Zfish   306 IKQLFLKKNKV------------------------------------TSPDKPMPCSQEDLSRLP 334

  Fly   370 KDLNALRCQEK----QK--QKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYN 421
            .|....|.|||    ||  ||.::..:..:...|..|..|...|..:|:....:..:|
Zfish   335 PDQRRRRLQEKVEEVQKELQKELEQSEALMKMKGVYEQNSQLGDPASLQPQITQTAHN 392

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	43/250 (17%)
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
trip10b	NP_956518.1	F-BAR_CIP4-like	7..255	CDD:153337	47/266 (18%)
		HR1_CIP4_FNBP1L	334..414	CDD:212018	15/59 (25%)
		SH3_CIP4-like	457..511	CDD:212844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910