DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and Trip10

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001229318.1	Gene:	Trip10 / 106628	MGIID:	2146901	Length:	603	Species:	Mus musculus

Alignment Length:	640	Identity:	119/640 - (18%)
Similarity:	219/640 - (34%)	Gaps:	179/640 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 LRLMETMKRSIQMKAKCDKEYAISLTAVAQQGL-KIDRADEMQGSLI-SKSWRSYMDELDHQAKQ 86
            |.|::...:.::.:|:.::.||..|.::.::.| |....|:.:.... .:|:...:.|::..|.|
Mouse    22 LDLLDKYVKFVKERAEVEQAYAKQLRSLVKKYLPKRPTKDDPEVKFSQQQSFVQLLQEVNDFAGQ 86

  Fly    87 FKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEHAKIAARLNHLTDEVVRKKSEYQKHL-EGYKA 149
            .:..||.|.: ||.:|...||:.::.||.:.:|..:...:|.:...::...|.::::.. |..||
Mouse    87 RELVAESLGIRVCLELAKYSQEMKQERKMHFQEGRRAQQQLENGFKQLENSKRKFERDCREAEKA 151

  Fly   150 LRT--RFEE--NYIKAPSRSGRKLDDVRDKYQKACRKLHL---THNEYVLSITEAIEVEKDFRNV 207
            ..|  |.::  |..||         ||....|:|..:.|:   :.|||...:......:..|...
Mouse   152 AHTAERLDQDINATKA---------DVEKAKQQAHLRNHMAEESKNEYAAQLQRFNRDQAHFYFS 207

  Fly   208 LLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRIDTVIG-----------SINP 261
            .:|.:.:..|.:.|      |...:..|.||.|:     |.:.::..:||           |::.
Mouse   208 QMPQIFDKLQDMDE------RRATRLGAGYGLLS-----EAELQVVPIIGKCLEGMKVAAESVDA 261

  Fly   262 TEEYGEFTEKYKTSPTTPLLFQFDE--TLIQDIPGKLQSSTLTVDNLTVDWLRNRLQELEGAVRD 324
            ..:.....|.:|:....|...:|::  .:|..:|.  .||..|.|.         ..||..|...
Mouse   262 KNDSQVLIELHKSGFARPGDLEFEDFSQVINRVPS--DSSLGTPDG---------RPELRAASSR 315

  Fly   325 CQEKQMKMIEHVNGGSP---VANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQEKQKQKLV 386
            .:.|:....:......|   :..|.:.|..|:..:..:|.:|.|...|:      ..:..|.:|.
Mouse   316 SRAKRWPFGKKNKPRPPSLSLLGGHLPSTLSDGPSSPRSGRDPLAILSE------ISKSVKPRLA 374

  Fly   387 DM--IKCALNEVGCEE---LPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGG 446
            ..  .:.....|..|:   ||.                   ||||..        :..:|..|..
Mouse   375 SFRSFRGGRGTVATEDFSHLPP-------------------EQQRKR--------LQQQLEERNR 412

  Fly   447 VLTLLRGRGRHFKR-----KSTPQPATPMTRSRQGRFNKLQPR-SQSLGSL-------------- 491
            .|.....:....|:     :.|||...|.:         |:|| :::||::
Mouse   413 ELQKEEDQREALKKMKDVYEKTPQMGDPAS---------LEPRIAETLGNIERLKLEVQKYEAWL 468

  Fly   492 -------------SVIRDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQ 543
                         |:.|....|.|....|                .:.::||||........
Mouse   469 AEAESRVLSNRGDSLSRHARPPDPPTTAP----------------PDSSSSSTNSGSQDNKE--- 514

  Fly   544 CSMLCLGEDEEPVVLASPAPLTQLTAAVLTNTNNNHIYADLELDKKKDTSPSPEC 598
                  ...|||.......|                ||.:.:.|.::..||..:|
Mouse   515 ------SSSEEPPSEGQDTP----------------IYTEFDEDFEEPASPIGQC 547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	51/229 (22%)
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
Trip10	NP_001229318.1	Required for podosome formation and interaction with AKAP9 and microtubules. /evidence=ECO:0000250	1..117		23/94 (24%)
		Required for translocation to the plasma membrane in response to insulin	1..117		23/94 (24%)
		F-BAR_CIP4-like	5..257	CDD:153337	54/254 (21%)
		Interaction with PDE6G. /evidence=ECO:0000250	293..603		59/349 (17%)
		Interaction with CDC42. /evidence=ECO:0000250	293..539		56/339 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	295..358		14/73 (19%)
		HR1_CIP4_FNBP1L	395..475	CDD:212018	18/115 (16%)
		Required for interaction with FASLG and localization to lysosomes. /evidence=ECO:0000250	471..603		19/118 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	477..541		16/104 (15%)
		Interaction with DNM2 and WASL. /evidence=ECO:0000269\|PubMed:16418535	487..543		14/96 (15%)
		Interaction with DNM1 and WASL. /evidence=ECO:0000250	532..603		4/16 (25%)
		Required for podosome formation. /evidence=ECO:0000250	540..603		3/8 (38%)
		Interaction with WAS. /evidence=ECO:0000250	546..603		1/2 (50%)
		SH3_CIP4-like	546..600	CDD:212844	1/2 (50%)
		Interaction with ARHGAP17, DAAM1, DIAPH1 and DIAPH2. /evidence=ECO:0000250	548..603		119/640 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910