DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and hck

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_005174178.1	Gene:	hck / 101885596	ZFINID:	ZDB-GENE-090313-72	Length:	499	Species:	Danio rerio

Alignment Length:	401	Identity:	144/401 - (35%)
Similarity:	219/401 - (54%)	Gaps:	42/401 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   940 VPS-LAASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFLVR--ETIRNEESQIVLSV 997
            :|| ..|..:|.|      ||||...:.|::..|.|    |..|.|::|  ||.:...|   |||
Zfish   102 IPSNYVAKDTLET------EEWFFKGVSRKDAERQLLASGNKTGSFMIRDSETTKGSYS---LSV 157

  Fly   998 CWNGH-----KHFIVQTTGEGNFRFEGP--PFASIQELIMHQYHSE---LPVTVKSGAIL---RR 1049
            ..:.|     ||:.::|...|.| :..|  .|.::|:|:.| |..:   |..::.|..:.   ::
Zfish   158 RDSDHQADTVKHYKIRTLDNGGF-YISPRITFNTLQDLVSH-YKKQSDGLCQSLTSPCLSPKPQK 220

  Fly  1050 PVCRERWELSNDDVVLLERIGRGNFGDVYKAKL-KSTKLDVAVKTCRMTLPDEQK-RKFLQEGRI 1112
            |..::.||:..:.:.|.:|:|.|.||:|:.|.. |.||  |||||.:   |.... ..||.|..:
Zfish   221 PWEKDAWEIPRESLKLDKRLGAGQFGEVWMAMYNKHTK--VAVKTMK---PGSMSVEAFLMEANL 280

  Fly  1113 LKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKN-SNGLTTRQQMGMCRDAAAGMRYL 1176
            :|...|..:|:|..:..:::||.|:.|.:..||||.:::.: .|.:...:.:......|.||.|:
Zfish   281 MKSLQHDKLVRLNAVVTKEEPIYIITEFMEKGSLLDFIKSDEGNRVQLPKLIDFSAQIAEGMAYI 345

  Fly  1177 ESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTS 1239
            |.:|.|||||.|.|.||:.....||:|||::|  |:.||...:|.| .|:|||||||:|:|.:|.
Zfish   346 EQRNYIHRDLRAANILVNKSLVCKIADFGLARIIEDNEYTAREGAK-FPIKWTAPEAINYGSFTI 409

  Fly  1240 LCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESR 1304
            ..||||:|||:.||.|.|.|||.||||......::.||||....|.|:|:|.:||:||....|.|
Zfish   410 KSDVWSFGILLTEIISYGRTPYPGMTNPEVIRALERGYRMQRLDSCPQELYDIMLECWKNKPEDR 474

  Fly  1305 PHFDEIYNVVD 1315
            |.|:.:.:|::
Zfish   475 PTFEYLQSVLE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/101 (30%)
		TyrKc	1063..1311	CDD:197581	104/252 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	104/252 (41%)
hck	XP_005174178.1	SH3	58..109	CDD:302595	2/6 (33%)
		SH2	113..215	CDD:301589	32/112 (29%)
		PTKc_Hck	222..487	CDD:270658	107/270 (40%)
		Pkinase_Tyr	234..484	CDD:285015	104/255 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910