DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and limk1b

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_005161503.1	Gene:	limk1b / 101883214	ZFINID:	ZDB-GENE-110411-106	Length:	615	Species:	Danio rerio

Alignment Length:	321	Identity:	86/321 - (26%)
Similarity:	158/321 - (49%)	Gaps:	40/321 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1036 ELPVTVKSGAIL--RRPVCRE---RWELSND---------DVVLLERIGRGNFGDVYKAKLKSTK 1086
            ::|...:..|:|  ||.:.|.   |:: :||         |::..|.:|:|.||...|.....|.
Zfish   260 KVPCLQRHAALLSHRRDINRSESLRFD-ANDKTQRIFRPSDLIYGEILGKGCFGQAIKVTHLETG 323

  Fly  1087 LDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLR 1151
            ..:.:|.. :...:|.::.||:|.::::..:|||::|.|||..:.:.:.::.|.|.||:|...:.
Zfish   324 EVMVIKEL-LQFDEETQKTFLKEVKVMRCLEHPNVLKFIGILYKDKRLNLISEYVQGGTLRDTIL 387

  Fly  1152 KNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR-EEEEYIV 1215
            |.::......::...:|.||||.||.|.|.|||||.:.||.|....:|.::|||::: .::|...
Zfish   388 KMASDHPWNLRVSYAKDIAAGMAYLHSMNVIHRDLNSHNCFVRENQTVVVADFGLAQLVKDEKTS 452

  Fly  1216 SDGM----------KQIPV----KWTAPEALNFGKYTSLCDVWSYGILMWEIFSK--GDTPYSGM 1264
            |.|.          |:..|    .|.|||.:|...|....|::|:||::.||..:  .|..:...
Zfish   453 SPGQMSKLNKLGRKKRYTVVGNPYWMAPEMINGKIYDERVDIFSFGIVLCEIIGRVYADPDFLPR 517

  Fly  1265 TNS---RARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLD 1322
            |..   ..:|.::..:    .|..|...:.:.:.|.|.:||.||.|.::...::.:::.|:
Zfish   518 TQEYGLNVKEFLERCW----SKDCPAAFFPIAVLCCALEAEKRPVFAKLEEWLENVMMHLE 574

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	0/2 (0%)
		TyrKc	1063..1311	CDD:197581	75/267 (28%)
		PTKc_Fes_like	1067..1315	CDD:270637	75/267 (28%)
limk1b	XP_005161503.1	LIM	<17..42	CDD:295319
		LIM2_LIMK	50..104	CDD:188751
		TyrKc	303..566	CDD:197581	75/267 (28%)
		PKc_like	306..573	CDD:304357	74/271 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910