DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and TNK2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_011510619.1	Gene:	TNK2 / 10188	HGNCID:	19297	Length:	1219	Species:	Homo sapiens

Alignment Length:	266	Identity:	96/266 - (36%)
Similarity:	146/266 - (54%)	Gaps:	24/266 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1058 LSNDDVVLLERIGRGNFGDVYKAKLKSTK---LDVAVKTCRMTLPD-----EQKRKFLQEGRILK 1114
            :...|:.|||::|.|:||.|.:.:..:..   :.||||..:   ||     |....|::|...:.
Human   285 IGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLK---PDVLSQPEAMDDFIREVNAMH 346

  Fly  1115 QYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSN----GLTTRQQMGMCRDAAAGMRY 1175
            ..||.|:::|.|: |...|:.:|.||...||||..|||:..    |..:|..:    ..|.||.|
Human   347 SLDHRNLIRLYGV-VLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAV----QVAEGMGY 406

  Fly  1176 LESKNCIHRDLAARNCLVDLEHSVKISDFGMSR---EEEEYIVSDGMKQIPVKWTAPEALNFGKY 1237
            ||||..|||||||||.|:.....|||.|||:.|   :.:::.|....:::|..|.|||:|....:
Human   407 LESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTF 471

  Fly  1238 TSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERID-TGYRMPTPKSTPEEMYRLMLQCWAADA 1301
            :...|.|.:|:.:||:|:.|..|:.|:..|:...:|| .|.|:|.|:..|:::|.:|:||||...
Human   472 SHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKP 536

  Fly  1302 ESRPHF 1307
            |.||.|
Human   537 EDRPTF 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	95/261 (36%)
		PTKc_Fes_like	1067..1315	CDD:270637	93/257 (36%)
TNK2	XP_011510619.1	SAM_TNK-like	170..231	CDD:188938
		STYKc	290..549	CDD:214568	95/261 (36%)
		PTKc_Ack_like	294..551	CDD:270636	93/257 (36%)
		SH3_9	559..608	CDD:291278
		GTPase_binding	611..678	CDD:286160
		Inhibitor_Mig-6	953..1017	CDD:288414
		UBA_ACK1	1140..1183	CDD:270460
		UBA_TNK1	1170..1209	CDD:270513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910