DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and ros1

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:XP_031758565.1 Gene:ros1 / 101733913 XenbaseID:XB-GENE-991394 Length:2240 Species:Xenopus tropicalis


Alignment Length:1497 Identity:321/1497 - (21%)
Similarity:527/1497 - (35%) Gaps:511/1497 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   165 SGRKLDDVRDKYQKACRKLHLTHNEYVLSITEAIEVEKDFRNVL--LPGLLEH----------QQ 217
            :|:|...|::..|.||     ||    .|..........|.|.|  |||...:          ..
 Frog   863 NGQKYITVQEISQPAC-----TH----FSQPAEFSTFTIFHNSLKPLPGNFSYIPRVIPDVVPSS 918

  Fly   218 SVQ-----ESFILLWRNILQEAAQYGDL----TADKYKEIQKRID-------------TVIGSIN 260
            ||:     .||::||:.  .|...||.:    .::|.:::|...:             ..:|.:.
 Frog   919 SVEIRGSYSSFVVLWKR--PENVDYGTIFYCVKSNKLQQLQGTANGACLTSEDFINSSYTVGGLG 981

  Fly   261 PTEEYGEFTEKYK---TSPTTPLLFQFDETLIQDIPGK--------LQSST------LTVD---- 304
            |.||:......|.   ..|||.|:.:..|    .:|.:        ||:::      :.|:    
 Frog   982 PYEEFDFAITPYTFWGRGPTTSLILRAPE----GVPSQPLKPRMFLLQNNSFFEGAKIAVELRWD 1042

  Fly   305 --NLT-----------------------VDW-------LRNRLQELE---GAVRDCQEKQMKMIE 334
              |:|                       .:|       |::.:|..:   |::...|.|....: 
 Frog  1043 NPNMTNGVLIQFTVCYRVFSECLFSTSLANWTTIDTTGLQHSVQLYDLCPGSILQFQVKAFTSL- 1106

  Fly   335 HVNGGSPV-----ANGS-------IISNGSNTSNGIQSNK-DSLCRQS--KDLNALRCQEKQKQK 384
               |..|.     ||.|       :||......|.:.::| |.:...|  |||.|: .......|
 Frog  1107 ---GPGPFSALVQANISDVGPAPALISFYPRLLNFLDTDKRDVIWNASTDKDLRAV-TYTANNGK 1167

  Fly   385 LVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYN--------------NEQQRSNSTSSPGL 435
            |..::.   :.:.|..|.:| ...|.|:...:.:.|:              ..:|..|......|
 Frog  1168 LYYILG---DSLFCRHLENG-SSALLLKNEHLSSSYSMTADWIPRHIYVAVRTEQEINHIYILDL 1228

  Fly   436 GIMNELMRR---GGVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDG 497
            ...|.:::.   ..:||:|             .....:..|...|...::  |..:|        
 Frog  1229 EQKNIVLKHINSSQILTIL-------------NIEAILVYSLLSRLYCVE--STEMG-------- 1270

  Fly   498 NGPSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEE---PVVLA 559
                    :.|..:.::.....|.||....|.:        .:...||  ||.:..|   |:.|.
 Frog  1271 --------KQIFYYDIKNDTVYHVLGHGNKTDA--------FKTNACS--CLVDSSEIGLPIALD 1317

  Fly   560 SPAPLTQLTAAVLTNTNNNHIY----------ADLE------------LDKKKDT---------- 592
            |            ||.||.:||          :|||            |...|.|          
 Frog  1318 S------------TNINNPYIYFLKNSTDVWASDLEGCHCWWVISINLLPGSKITGLAVDDYYIY 1370

  Fly   593 -SPSPECKGEQIQPK---KEQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNA 653
             |.:.:......|..   |....:::.|..||               :|  ....:|||..|...
 Frog  1371 WSTAGKDNATIYQASKLTKSPALLQVEQGHPQ---------------IL--AFTTSLQPFPDKCC 1418

  Fly   654 IESAEENHIQTRKLAKDPDSQTKRSSSSSSEC----------------RSSKDTSHSKKRSLSFS 702
            | ....|..|.:.|.|...|.|...:.:.::|                ::.::.::|.:.||..|
 Frog  1419 I-VLSLNQDQPKILTKTNTSFTLEMTQARTQCPCPLIGSTTPTYTVKYKNLREHTNSFENSLDNS 1482

  Fly   703 -------QKSISNIFSNLKEFSKSPL---VRMGKNHILNEEQDAKRTQPSQHHHSSG--SDCPTN 755
                   |::|::|. .|:.::...|   :|...:.:|.:|..||.......:...|  ||....
 Frog  1483 ACTIAEYQENIADIL-GLQPYTTYVLEVNLRNYYSFLLAQEPAAKTVTGKTDYGVPGAVSDITLT 1546

  Fly   756 SSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITT--------------------------TITT 794
            ..|..:.|....:....|....|.:..|:::.:..                          ||..
 Frog  1547 VWSDYAVNITWQEPAQPNGPVVAIRYQIMSNMLPPFPASPWRKSDFPEGLLKSAYTGLHGGTIYK 1611

  Fly   795 TTTT---------TPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLN------------FQLKRSK 838
            .|..         |.|...:.|.|:.|.:   .|.|.....|.||.            |:||..|
 Frog  1612 FTVLAFHPDENWFTESAAVNALTFQKPSV---PKIIVPGNTSLLLEWKQPQEDITDFWFELKNPK 1673

  Fly   839 -----PCK-QCTKR------------RRIHPSKSVFDF---AKEF----EVEQPAGSAADEQFCN 878
                 |.. .|||:            ..|:..|:|..|   ||.|    |.:..||         
 Frog  1674 EEWYVPINTSCTKKSVYMCTLIGVQPNMIYSVKAVVIFTTAAKSFSDSAEFKTTAG--------- 1729

  Fly   879 CPPAGQKPVKPSVQISGHKD----HPFESSSGE------LDENSDRDIDNDEE------------ 921
                  .|.||.|. .|.::    .|.|..:|.      |:.....|.||:|.            
 Frog  1730 ------VPGKPGVP-QGKQNIIQWMPVEEDNGSNIIYYILEYRELHDDDNNESKPWLTAYNGSCP 1787

  Fly   922 ---------------------------EEDSASDDVLSMK---DHCYCVPSLAASISLSTNRPLY 956
                                       |..:.|:.::..|   |    |.:|.|.|         
 Frog  1788 NICVWEAHEIKGTFEFRAAAANGIGLGEYSNTSESIIFFKRKTD----VTALVAGI--------- 1839

  Fly   957 EEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCW-NGHKHFIVQTTGEGNFRFEGP 1020
                ..|:|    :|.|:                  :..::.| :..|....:||...       
 Frog  1840 ----LSGIL----IVLLI------------------VAFALYWMSKQKSQKKETTAVA------- 1871

  Fly  1021 PFASIQELIMHQYHSELPVTVKSG--AILRRPVCRERWELSN---DDVVLLERIGRGNFGDVYKA 1080
             ....:||:..:..|: .|.:.:|  |:...|..:|:.:|.|   :.:.|...:|.|.||:||  
 Frog  1872 -ILEDKELMKLRGLSD-AVGLANGCYAVSILPTQKEKEKLPNFPREKLTLCVFLGSGAFGEVY-- 1932

  Fly  1081 KLKSTKLD----------VAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIM 1135
              :...:|          |||||.:....|.:|.:||:|..::.|:|||||:||:|:|:..:|..
 Frog  1933 --EGAAIDILGPETGIKKVAVKTLKRDATDHEKTEFLKEAHLMSQFDHPNILKLLGVCLFNEPQY 1995

  Fly  1136 IVMELVLGGSLLTYLR-------KNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLV 1193
            |::||:.||.||||||       ..:..|:|...:.:..:.:.|..|||..:.:|||||||||||
 Frog  1996 IILELMDGGDLLTYLRGARVDSFTQNPLLSTLDLLDISENISRGCAYLEKMHFVHRDLAARNCLV 2060

  Fly  1194 DLE------HSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILM 1250
            .::      ..|||.|||::|:  :.:|...:|...:||:|.|||:|..|.:|...||||:||::
 Frog  2061 SVKEYNNPSRIVKIGDFGLARDIYKCDYYRKNGEGLLPVRWMAPESLIDGIFTCRSDVWSFGIVL 2125

  Fly  1251 WEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVD 1315
            ||:|:.|..||.|.:|......:.:|.||.:|.:.|::::.|:.:|||.|...||.|..:...::
 Frog  2126 WEVFTMGQQPYPGFSNLEVLHHVQSGQRMCSPTNCPDDVWSLIQKCWAQDPWKRPAFSFLQKQLE 2190

  Fly  1316 AL 1317
            .|
 Frog  2191 KL 2192

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341 24/98 (24%)
SH2_Fps_family 953..1039 CDD:198224 11/86 (13%)
TyrKc 1063..1311 CDD:197581 102/272 (38%)
PTKc_Fes_like 1067..1315 CDD:270637 101/272 (37%)
ros1XP_031758565.1 FN3 67..>134 CDD:238020
FN3 166..247 CDD:238020
FN3 529..631 CDD:238020
fn3 1037..1112 CDD:394996 11/78 (14%)
FN3 1537..1636 CDD:238020 14/98 (14%)
FN3 1637..1726 CDD:238020 22/91 (24%)
PKc_like 1922..2190 CDD:419665 101/271 (37%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.