DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment FER and tyk2

DIOPT Version :9

Sequence 1:NP_524288.3 Gene:FER / 41118 FlyBaseID:FBgn0000723 Length:1325 Species:Drosophila melanogaster
Sequence 2:XP_003198201.2 Gene:tyk2 / 100536675 ZFINID:ZDB-GENE-071116-4 Length:1165 Species:Danio rerio


Alignment Length:944 Identity:203/944 - (21%)
Similarity:332/944 - (35%) Gaps:232/944 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   495 RDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLA 559
            |..|.|.....||  .|.:|.:.|......:.:...:...|.:..:..:.:.|   .:||...:.
Zfish   295 RTQNPPEETINEP--THEIRVSGSDGIWWRKFSAQRSQSDDYSHSQNKETAAL---NEEEDWNIF 354

  Fly   560 SPAPLTQLTAAVLTN---TNNNHIYADLELDKK--------------KDTSPSPECKGEQIQPKK 607
            ...|...|.|....|   :..:::..|:.||..              :.|:.:......::.|. 
Zfish   355 CDFPEISLIAIQGINVCISRQDNMSMDISLDSSIQARSLVSLLDGYFRLTTDAHHYLCREVAPP- 418

  Fly   608 EQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENHI------QTRK 666
               |:.:::     |.|.|...:||.  || .:|||.::....:....:.:.:.|      :::|
Zfish   419 ---RVVLSE-----SNDLHGPLMDEF--VL-QKLKREVEEGAFLVRWSALDYHRIILASLSRSKK 472

  Fly   667 LAKDPDSQTKR---------------SSSSSSECRSSKDTSHSKKRSLSFSQK--------SISN 708
            ..::|..:..|               ..||..|..||..|...|....||:.|        .:||
Zfish   473 EGENPVYKQFRIRQNGSLFHLEGWDQDFSSIKELTSSLKTFVLKSGEDSFTLKKCCLPKPGELSN 537

  Fly   709 IF-------SNLKEFSKSP-LVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNN 765
            :.       |::|..|::| |.::..|.|.::|      ...:.|...|:.....|.......:.
Zfish   538 LLIIRKGAKSSIKSASETPDLSKLSFNPIKDKE------ITKEQHLGRGTRTNIYSGWLKIRGSL 596

  Fly   766 NNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKK------------- 817
            .:::..||:||..::...:...|        .....|:.:...|:...:..:             
Zfish   597 EDEDDESNNNHCKTKGIRVVLKI--------LEQSQKDKALAFFETASLMSQVSHCHLIFVHGLS 653

  Fly   818 SKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKS-VFDFAKE-------FEVEQPA-GSAAD 873
            .|...|....:.:.|     .|......|.|.|.|.. .|..||:       .|.::.. |:...
Zfish   654 VKGTENIMVEEFVEF-----GPLDVFLHRERAHVSPQWKFTVAKQLASALCYLETKRLVHGNVCG 713

  Fly   874 EQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCY 938
            :.........::...|.|::|                            :...|...||..:...
Zfish   714 KNILVVRKGLEEGTSPFVKLS----------------------------DPGISLSALSQGERVE 750

  Fly   939 CVPSLAAS-ISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGH 1002
            .:|.:|.. ::..|......::|..|.                            .:|.:|.||.
Zfish   751 RIPWIAPECVADGTRIGSAADKWSFGA----------------------------TLLEICNNGD 787

  Fly  1003 KHFIVQTTGEGNFRFEGP---PFASIQELIMHQYHSELPVTVKSGAILR---RPVCRERWE--LS 1059
            .|....|..|....:|..   ...|.|||.     |.:...:...|..|   |.:.||..|  :.
Zfish   788 LHVSNSTLSEKQRFYETQSRLAVPSSQELA-----SFISRCLTYDAAARPSFRTILRELTEIQIK 847

  Fly  1060 NDDV-------------VLLER-------IGRGNFGD----VYKAKLKSTKLDVAVKTCRMTLPD 1100
            |.|:             |..:|       :|.|:||.    ||......|...||||..:.....
Zfish   848 NPDISSECESLPDKDPSVFYKRYLRKIRDLGEGHFGKVMLYVYDPHNDGTGEYVAVKALKQEGDG 912

  Fly  1101 EQKR-KFLQEGRILKQYDHPNIVKLIGICVQK--QPIMIVMELVLGGSLLTYLRKNSNGLTTRQQ 1162
            .... .:::|..|||...|.||||..|.|.:.  |.:.::||.|..|||..|:.|...|:  .|.
Zfish   913 SSLHVSWMKEIEILKSLYHNNIVKYKGCCTEMGGQVVQLIMEYVPLGSLREYMPKYGQGI--GQG 975

  Fly  1163 MGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR---EEEEY--IVSDGMKQI 1222
            :...:....||.||.||..|||||||||.|::.|..|||.|||:::   |.:.|  :..||  ..
Zfish   976 LLFAQQICLGMDYLHSKRYIHRDLAARNVLLENEGVVKIGDFGLTKYIPEGDIYYRVREDG--DS 1038

  Fly  1223 PVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGD--------------TPYSGMTNSRARERI 1273
            ||.|.|.|.|...|::...||||:.:.::||.:...              |.:..||..:....:
Zfish  1039 PVFWYAIECLKESKFSFASDVWSFAVTLYEILTNCSHRLSPPSKFSDMMGTVHGQMTVVKLISLL 1103

  Fly  1274 DTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            :...|:|.|...|.|:|.||.|||..:.:.||.|
Zfish  1104 EKNERLPCPPGCPREVYSLMEQCWDFNPDQRPSF 1137

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FERNP_524288.3 F-BAR_Fes_Fer 7..243 CDD:153341
SH2_Fps_family 953..1039 CDD:198224 15/88 (17%)
TyrKc 1063..1311 CDD:197581 92/291 (32%)
PTKc_Fes_like 1067..1315 CDD:270637 91/274 (33%)
tyk2XP_003198201.2 B41 46..273 CDD:214604
FERM_C_TYK2 268..414 CDD:275414 20/123 (16%)
SH2 414..511 CDD:301589 21/108 (19%)
PKc_like 571..842 CDD:304357 52/344 (15%)
Pkinase_Tyr 571..841 CDD:285015 51/343 (15%)
PKc_like 866..1147 CDD:304357 91/276 (33%)
Pkinase_Tyr 871..1144 CDD:285015 90/271 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100013
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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