DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and tyk2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_003198201.2	Gene:	tyk2 / 100536675	ZFINID:	ZDB-GENE-071116-4	Length:	1165	Species:	Danio rerio

Alignment Length:	944	Identity:	203/944 - (21%)
Similarity:	332/944 - (35%)	Gaps:	232/944 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   495 RDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLA 559
            |..|.|.....||  .|.:|.:.|......:.:...:...|.:..:..:.:.|   .:||...:.
Zfish   295 RTQNPPEETINEP--THEIRVSGSDGIWWRKFSAQRSQSDDYSHSQNKETAAL---NEEEDWNIF 354

  Fly   560 SPAPLTQLTAAVLTN---TNNNHIYADLELDKK--------------KDTSPSPECKGEQIQPKK 607
            ...|...|.|....|   :..:::..|:.||..              :.|:.:......::.|.
Zfish   355 CDFPEISLIAIQGINVCISRQDNMSMDISLDSSIQARSLVSLLDGYFRLTTDAHHYLCREVAPP- 418

  Fly   608 EQIRIEINQTAPQNSIDAHLDRIDELNRVLDDRLKRTLQPSDDVNAIESAEENHI------QTRK 666
               |:.:::     |.|.|...:||.  || .:|||.::....:....:.:.:.|      :::|
Zfish   419 ---RVVLSE-----SNDLHGPLMDEF--VL-QKLKREVEEGAFLVRWSALDYHRIILASLSRSKK 472

  Fly   667 LAKDPDSQTKR---------------SSSSSSECRSSKDTSHSKKRSLSFSQK--------SISN 708
            ..::|..:..|               ..||..|..||..|...|....||:.|        .:||
Zfish   473 EGENPVYKQFRIRQNGSLFHLEGWDQDFSSIKELTSSLKTFVLKSGEDSFTLKKCCLPKPGELSN 537

  Fly   709 IF-------SNLKEFSKSP-LVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNN 765
            :.       |::|..|::| |.::..|.|.::|      ...:.|...|:.....|.......:.
Zfish   538 LLIIRKGAKSSIKSASETPDLSKLSFNPIKDKE------ITKEQHLGRGTRTNIYSGWLKIRGSL 596

  Fly   766 NNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKK------------- 817
            .:::..||:||..::...:...|        .....|:.:...|:...:..:
Zfish   597 EDEDDESNNNHCKTKGIRVVLKI--------LEQSQKDKALAFFETASLMSQVSHCHLIFVHGLS 653

  Fly   818 SKAIRNTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKS-VFDFAKE-------FEVEQPA-GSAAD 873
            .|...|....:.:.|     .|......|.|.|.|.. .|..||:       .|.::.. |:...
Zfish   654 VKGTENIMVEEFVEF-----GPLDVFLHRERAHVSPQWKFTVAKQLASALCYLETKRLVHGNVCG 713

  Fly   874 EQFCNCPPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCY 938
            :.........::...|.|::|                            :...|...||..:...
Zfish   714 KNILVVRKGLEEGTSPFVKLS----------------------------DPGISLSALSQGERVE 750

  Fly   939 CVPSLAAS-ISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGH 1002
            .:|.:|.. ::..|......::|..|.                            .:|.:|.||.
Zfish   751 RIPWIAPECVADGTRIGSAADKWSFGA----------------------------TLLEICNNGD 787

  Fly  1003 KHFIVQTTGEGNFRFEGP---PFASIQELIMHQYHSELPVTVKSGAILR---RPVCRERWE--LS 1059
            .|....|..|....:|..   ...|.|||.     |.:...:...|..|   |.:.||..|  :.
Zfish   788 LHVSNSTLSEKQRFYETQSRLAVPSSQELA-----SFISRCLTYDAAARPSFRTILRELTEIQIK 847

  Fly  1060 NDDV-------------VLLER-------IGRGNFGD----VYKAKLKSTKLDVAVKTCRMTLPD 1100
            |.|:             |..:|       :|.|:||.    ||......|...||||..:.....
Zfish   848 NPDISSECESLPDKDPSVFYKRYLRKIRDLGEGHFGKVMLYVYDPHNDGTGEYVAVKALKQEGDG 912

  Fly  1101 EQKR-KFLQEGRILKQYDHPNIVKLIGICVQK--QPIMIVMELVLGGSLLTYLRKNSNGLTTRQQ 1162
            .... .:::|..|||...|.||||..|.|.:.  |.:.::||.|..|||..|:.|...|:  .|.
Zfish   913 SSLHVSWMKEIEILKSLYHNNIVKYKGCCTEMGGQVVQLIMEYVPLGSLREYMPKYGQGI--GQG 975

  Fly  1163 MGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR---EEEEY--IVSDGMKQI 1222
            :...:....||.||.||..|||||||||.|::.|..|||.|||:::   |.:.|  :..||  ..
Zfish   976 LLFAQQICLGMDYLHSKRYIHRDLAARNVLLENEGVVKIGDFGLTKYIPEGDIYYRVREDG--DS 1038

  Fly  1223 PVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGD--------------TPYSGMTNSRARERI 1273
            ||.|.|.|.|...|::...||||:.:.::||.:...              |.:..||..:....:
Zfish  1039 PVFWYAIECLKESKFSFASDVWSFAVTLYEILTNCSHRLSPPSKFSDMMGTVHGQMTVVKLISLL 1103

  Fly  1274 DTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            :...|:|.|...|.|:|.||.|||..:.:.||.|
Zfish  1104 EKNERLPCPPGCPREVYSLMEQCWDFNPDQRPSF 1137

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	15/88 (17%)
		TyrKc	1063..1311	CDD:197581	92/291 (32%)
		PTKc_Fes_like	1067..1315	CDD:270637	91/274 (33%)
tyk2	XP_003198201.2	B41	46..273	CDD:214604
		FERM_C_TYK2	268..414	CDD:275414	20/123 (16%)
		SH2	414..511	CDD:301589	21/108 (19%)
		PKc_like	571..842	CDD:304357	52/344 (15%)
		Pkinase_Tyr	571..841	CDD:285015	51/343 (15%)
		PKc_like	866..1147	CDD:304357	91/276 (33%)
		Pkinase_Tyr	871..1144	CDD:285015	90/271 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810