DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and lrit2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_002933949.1	Gene:	lrit2 / 100497156	XenbaseID:	XB-GENE-923281	Length:	570	Species:	Xenopus tropicalis

Alignment Length:	291	Identity:	60/291 - (20%)
Similarity:	107/291 - (36%)	Gaps:	74/291 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 WFHGVLPREEVVRLLNNDGDFLVRETIRNE---------ESQIVLSVCWNGHKHFI--------- 1006
            |.:|:    :||:..|.....:..|||::|         ::.|...:..|    |:
Frog   285 WTYGL----KVVKAFNVSTTTINEETIKSELIIPAVHVTDAGIYKCIATN----FLGNSSASILL 341

  Fly  1007 -VQTTGEGN----FRFEGPPFASIQELIMHQY-------HSELPVTVKSGAILRRPVCRERW--- 1056
             ||:...||    ..:..||.:|..:  .|.:       .:...::::..|:...|  .|.|
Frog   342 NVQSNKLGNASPSLSYSLPPSSSSSQ--EHVFIDLRISKQTAYGISLEWFAVTENP--GETWYTI 402

  Fly  1057 -----ELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQY 1116
                 |.:..:|:   .||.|.:.......|..||.:|.| |.:..||.:.:......|..:.:.
Frog   403 YFGKYEDTQKEVI---NIGPGIYSYSVNDLLPITKYEVCV-TLKSQLPKKGQCIVFMTGSDISEL 463

  Fly  1117 DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGM--RYLESK 1179
            :...  |||.|      |:||..:||......|      ..||..:.. |.|...|:  |..:::
Frog   464 EQRE--KLIHI------IVIVCAMVLAVPAGMY------ACTTETRFN-CLDKCLGLCRRKHKAQ 513

  Fly  1180 NCIHRDLAARNCLVDLEHSVKISDFGMSREE 1210
            ..:.:|....:....|:.|   |:.|:.:.|
Frog   514 KTLKKDNTKESTFDSLQAS---SEEGLCQRE 541

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	20/108 (19%)
		TyrKc	1063..1311	CDD:197581	35/150 (23%)
		PTKc_Fes_like	1067..1315	CDD:270637	34/146 (23%)
lrit2	XP_002933949.1	leucine-rich repeat	56..79	CDD:275378
		LRR_8	57..114	CDD:338972
		leucine-rich repeat	80..103	CDD:275378
		LRR_8	103..162	CDD:338972
		leucine-rich repeat	104..127	CDD:275378
		leucine-rich repeat	128..151	CDD:275378
		leucine-rich repeat	152..165	CDD:275378
		leucine-rich repeat	176..203	CDD:275378
		TPKR_C2	199..249	CDD:387596
		IG_like	259..343	CDD:214653	12/65 (18%)
		fn3	373..444	CDD:365830	15/76 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910