DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and epha6

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_031752444.1	Gene:	epha6 / 100495504	XenbaseID:	XB-GENE-6032564	Length:	1008	Species:	Xenopus tropicalis

Alignment Length:	710	Identity:	191/710 - (26%)
Similarity:	311/710 - (43%)	Gaps:	163/710 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   671 PDSQTKRSSSSSSEC-----RSSKDTSH-------SKKRSLSFSQKSISNIFSNLKE----FSKS 719
            |.|.|...:::..:|     |:.||...       |..|:.:|          |:.|    ...|
Frog   298 PHSFTYAEATTVCQCEKGFYRAEKDPPSMACTKPPSAPRNANF----------NMNETALYLEWS 352

  Fly   720 PLVRMG--KNHILNEEQDAKRTQPSQHHHSSGS--DCPTNSSSSSSN------NNNNNKNTSSNS 774
            |.:..|  |:.:.|..  .|:..|||.....|.  ..|.:|...:::      .::.|......:
Frog   353 PPIDTGGRKDVVYNVL--CKKCDPSQCELCGGGIRYVPAHSGLQNASVTVLDFLSHVNYTFDIEA 415

  Fly   775 NHSASQSTIITSTITTTITTTTTTTPS----------KENS-RLKFKVPKIQKKSKAIRNTFRSK 828
            .:..|:.:.:....|:.:.||....||          .:|| .|.::.|...|          ..
Frog   416 TNGVSELSFLPKPYTSIMITTDQEAPSLIGMVRKDWASQNSIALSWQEPDYPK----------GL 470

  Fly   829 LLNFQLK---RSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKP---- 886
            ::::::|   :..|        ||.|  :.:.:.:..|.||.:.|:...:..:....|.||
Frog   471 IVDYEIKYYEKDYP--------RIAP--AFWHYLRVEEHEQLSYSSTRSKAPSVIITGLKPATKY 525

  Fly   887 -----VKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHC---YCVPSL 943
                 |:.:...|.: .|.||..:|  ||.||...:..:         :|.:....   :.:..:
Frog   526 IFHIRVRTTAGYSAY-SHKFEFETG--DETSDLAAEQGQ---------ILVIATAAVGGFTLLVI 578

  Fly   944 AASISLSTNRPLYEEEWFHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQ 1008
            .....|.|.|.    :|:                    ::..:::||.:  .:...|||..|...
Frog   579 LTLFFLITGRC----QWY--------------------IKAKMKSEEKR--RANLQNGHLQFPGV 617

  Fly  1009 TTGEGNFRFEGPPFASIQELIMHQYHSEL-PVTVKSGAILRRPVCRERWELSNDDVVLLER-IGR 1071
            .|......:|.|      .|.:|::..|: |..::                       :|| ||.
Frog   618 KTYIDPDTYEDP------SLAVHEFAKEIDPSRIR-----------------------IERVIGA 653

  Fly  1072 GNFGDVYKAKLKS---TKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQP 1133
            |.||:|...:||:   .::.||:||.:....|.|::.||:|..|:.|:|||||::|.|:..:.:|
Frog   654 GEFGEVCSGRLKTPAKKEIPVAIKTLKGGYVDRQRKDFLREASIMGQFDHPNIIRLEGVVTKSRP 718

  Fly  1134 IMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHS 1198
            :|||:|.:..|||.::|||:....|..|.:||.|..|:||:||.....:||||||||.||:....
Frog   719 VMIVVEYMENGSLDSFLRKHDGQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLV 783

  Fly  1199 VKISDFGMSREEEE-----YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGD 1258
            .|:||||:||..|:     |..:.|  :||::||||||:.|.|::|..|.|||||:|||:.|.|:
Frog   784 CKVSDFGLSRVLEDDPDAAYTTTGG--KIPIRWTAPEAIAFRKFSSASDAWSYGIVMWEVMSYGE 846

  Fly  1259 TPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            .||..|:|......|:.|||:|.|...|..:::|||.||..|...||.|.:|...:|.||
Frog   847 RPYWEMSNQDVILSIEEGYRLPAPMGCPVSLHQLMLHCWQKDRNIRPKFSDIVGFLDKLI 906

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	14/86 (16%)
		TyrKc	1063..1311	CDD:197581	111/256 (43%)
		PTKc_Fes_like	1067..1315	CDD:270637	112/256 (44%)
epha6	XP_031752444.1	EphR_LBD_A6	34..206	CDD:198452
		FN3	333..421	CDD:419708	18/99 (18%)
		FN3	441..548	CDD:238020	24/127 (19%)
		EphA2_TM	564..642	CDD:405290	16/109 (15%)
		PTKc_EphR_A	640..906	CDD:270651	114/290 (39%)
		SAM_EPH-A6	933..996	CDD:188946
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910