DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and matk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_031759675.1	Gene:	matk / 100494243	XenbaseID:	XB-GENE-485237	Length:	443	Species:	Xenopus tropicalis

Alignment Length:	381	Identity:	128/381 - (33%)
Similarity:	202/381 - (53%)	Gaps:	42/381 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 WFHGVLPREEVVRLL--NNDGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRFE-GP 1020
            ||||.:...:.|:.|  ..:|.|||||::|: ....||.||:... .|:.:...| |....: ..
Frog    81 WFHGAITGVQAVQQLQPKENGLFLVRESVRH-PGDYVLCVCFKDEVTHYRISNQG-GKLNIDLTQ 143

  Fly  1021 PFASIQELIMHQYHSELPVTVKSGAI---LRRPVCRE------------RWELSNDDVVLLERIG 1070
            .|.::.::|  :|:|     ...|.:   |.:|.|::            .|.|:..::.|.::||
Frog   144 NFNNLMDMI--EYYS-----AHQGVLTTRLIKPKCKQGMISAEQKLAKAGWLLNFQNLTLGKKIG 201

  Fly  1071 RGNFGDVYKAKLKSTKLDVAVKT--CRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQP 1133
            .|.||||.:.:....  .||:|.  |.||     .:.||.|...:.:..|.|:|.|:|: :.|..
Frog   202 EGEFGDVLQGEYMGR--PVAIKNIKCDMT-----AQNFLSETATMTKLQHKNLVNLLGV-ILKNG 258

  Fly  1134 IMIVMELVLGGSLLTYLRKNSNGLTTRQQMGM-CRDAAAGMRYLESKNCIHRDLAARNCLVDLEH 1197
            :::||||:..|:|:.|||.....:....|:.: ..|...||.|||.|..:||||||||.||..:.
Frog   259 LLLVMELMSKGNLVNYLRSRGRSMVPPYQLLIFSMDIVQGMEYLELKRLVHRDLAARNILVSEKG 323

  Fly  1198 SVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYS 1262
            ..||||||:|:.:   :..|.:.::|:||||||||...|::|..||||:|:|:||::|.|..||.
Frog   324 EAKISDFGLSKPQ---LQQDDLSRLPIKWTAPEALQNYKFSSRSDVWSFGVLLWEVYSYGRAPYP 385

  Fly  1263 GMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            .|:.....|.:..||||..|::.|..:|.:|..||.||...||.|.::...::.::
Frog   386 KMSVREVIEAVKKGYRMEAPENCPPMIYSIMKSCWEADPGKRPTFKKLKEKLETMM 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	24/82 (29%)
		TyrKc	1063..1311	CDD:197581	98/250 (39%)
		PTKc_Fes_like	1067..1315	CDD:270637	97/250 (39%)
matk	XP_031759675.1	SH3_CHK	9..67	CDD:212745
		SH2	77..174	CDD:417686	28/101 (28%)
		PTKc_Chk	187..440	CDD:270666	100/263 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000