DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and itk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_031754542.1	Gene:	itk / 100492561	XenbaseID:	XB-GENE-957720	Length:	616	Species:	Xenopus tropicalis

Alignment Length:	650	Identity:	190/650 - (29%)
Similarity:	307/650 - (47%)	Gaps:	110/650 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   726 KNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNNKNTSSNSNHSASQSTIITSTITT 790
            :..::.:.|..:||.|:  ::.|.....|:||.:...:..........|...|....:  ..:||
Frog     8 QQQLIKKSQQKRRTSPA--NYKSRIFILTHSSLNYYEHRQGKIRALRGSIDLARIKCV--EIVTT 68

  Fly   791 TITTTTTT---------------TPSKENSRLKFKVPKIQKKSKAIRNTFRSKLL-----NFQLK 835
            .::.....               .|.:| ||.|: |..:::::|  .|.|   |:     ||.|:
Frog    69 DLSIACRNKYPFQVIHDYFLYVFAPDRE-SRQKW-VLALKEETK--DNDF---LVAKYHSNFWLE 126

  Fly   836 RSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKDHP 900
            ....|  |.:..::....:::|.:|:                    ..:||:.|    :.:.:..
Frog   127 GRWRC--CFQTEKMATGCALYDRSKD--------------------VSKKPLPP----TPNDNMV 165

  Fly   901 FESSSG------ELDENSDRDIDNDEEEEDSASD-------DVLSMKDHCYCVPSLAASISLSTN 952
            |:::.|      :....|.:::.....||....|       .||....|...|||  :.::..|.
Frog   166 FQANQGWEVALYDYKAQSSQELTLCRGEEYLPLDTSEPHWWKVLDKNGHVGHVPS--SYLAKKTE 228

  Fly   953 RPLYEEEWFHGVLPREEVVRLLNN---DGDFLVRETIRNEESQIVLSVCW-----NGH--KHFIV 1007
            ..|...:|::..:.|...|:||.:   :|.|:||::  .:.....:|:..     |.|  ||:.:
Frog   229 DSLLAYKWYNKNVSRNLAVKLLTDQGKEGAFMVRDS--RQPGLYTVSIFTKALGENNHAVKHYHI 291

  Fly  1008 QTTGEGNFRF---EGPPFASIQELIMHQYHSELPVTVKSGAILRRPVC--RE-----------RW 1056
            :.|.:...::   |...|.||.|||.:..|:...:..:    ||.|||  :|           :|
Frog   292 RHTNDSPAKYYLAEKHVFNSIPELINYHQHNGAGLVTR----LRYPVCSWKETAPVTAGLSYGKW 352

  Fly  1057 ELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNI 1121
            |:....:.|.|.||.|.||.|..|..:.| ..||||..|..:..|:  .|::|.::|.:..||.:
Frog   353 EIDPTHLTLKEEIGSGQFGVVQLAIWQGT-TKVAVKMIREGMMSEE--DFVEEAQVLMKLSHPKL 414

  Fly  1122 VKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDL 1186
            |:|:|:|.|:.||.:|.|.:..|.|..|||.:...|:....:|||:|...||:|||..|.|||||
Frog   415 VQLLGVCTQQVPIFLVFEYMKYGCLFNYLRSHRGTLSKETALGMCQDVCEGMQYLERSNFIHRDL 479

  Fly  1187 AARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGIL 1249
            |||||||.....||:|||||:|  .:::|..|.|.| .||||:|||...||.|:|..||||:|:|
Frog   480 AARNCLVGESLVVKVSDFGMTRFVLDDQYTSSSGTK-FPVKWSAPEVFRFGLYSSRSDVWSFGVL 543

  Fly  1250 MWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVV 1314
            :||:||:|..|:..::||.|.|:|..|.|:..||.:.|.:|:||..||...|:.||.|.::...|
Frog   544 VWEVFSEGKIPFEHLSNSEAVEKISAGLRLFKPKMSSERVYKLMNNCWQEKADLRPTFQQLLKEV 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	24/98 (24%)
		TyrKc	1063..1311	CDD:197581	112/249 (45%)
		PTKc_Fes_like	1067..1315	CDD:270637	111/249 (45%)
itk	XP_031754542.1	PH_Btk	7..146	CDD:269944	27/150 (18%)
		SH3	174..226	CDD:418401	10/53 (19%)
		SH2_Tec_Itk	229..336	CDD:198259	28/112 (25%)
		PKc_like	354..608	CDD:419665	112/257 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000