Protein Alignment FER and abl1

DIOPT Version :10

• Sequence 1: NP_524288.3
• Gene: FER / 41118
• FlyBaseID: FBgn0000723
• Length: 1325
• Species: Drosophila melanogaster
• Sequence 2: XP_002936228.2
• Gene: abl1 / 100490771
• XenbaseID: XB-GENE-6054675
• Length: 1128
• Species: Xenopus tropicalis
• Alignment Length: 538
• Identity: 166/538 - (30%)
• Similarity: 259/538 - (48%)
• Gaps: 96/538 - (17%)

  Fly   841 KQCTKRRRIHPSKSVFDFAKEFEV-------EQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKD 898
            |:| :|::.....|.....|..|:       :...|.::... |....|.|:|....::..|
 Frog     9 KKC-RRQQKGAGASCMQHMKMLEICLKLVGCKSKKGLSSSSS-CYLEEALQRPTVSDIEPQG--- 68

  Fly   899 HPFESSSGELDE----NSDRDIDNDEEEED-----------SASDDVLSMK----------DHC- 937
                     |.|    ||..::.:...|.|           ::.|:.||:.          :|.
 Frog    69 ---------LSEAARWNSKENLLSGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNG 124

  Fly   938 -YC----------VPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNE 989
             :|          |||   :.....|.| .:..|:||.:.|.....||::  :|.|||||: .:.
 Frog   125 EWCEAQTKNGQGWVPS---NYITPVNSP-EKHSWYHGPVSRNAAEYLLSSGINGSFLVRES-ESS 184

  Fly   990 ESQIVLSVCWNGH-KHFIVQTTGEGNFRFEGPP-FASIQELIMHQYHSELPVTVKSGAI--LRRP 1050
            ..|..:|:.:.|. .|:.:.|..:|........ |.::.||:.|  ||    ||..|.|  |..|
 Frog   185 PGQRSISLRYEGRVYHYRINTASDGKLYVSSDSRFNTLAELVHH--HS----TVSDGLITTLHYP 243

  Fly  1051 VCR-------------ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRM-TLPDE 1101
            ..:             ::||:...|:.:..::|.|.:|:||:...|...|.|||||.:. |:..|
 Frog   244 APKRNKPTIYGVSPNYDKWEIERTDITMKHKLGGGQYGEVYEGVWKKYNLTVAVKTLKEDTMEVE 308

  Fly  1102 QKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK-NSNGLTTRQQMGM 1165
            :   ||:|..::|:..|||:|:|:|:|.::.|..|:.|.:..|:||.|||. |...:|....:.|
 Frog   309 E---FLKEAAVMKEVKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRDCNRQEVTAVVLLHM 370

  Fly  1166 CRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTA 1228
            ....::.|.|||.||.||||||||||||...|.||::|||:||  ..:.|....|.| .|:||||
 Frog   371 ATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTA 434

  Fly  1229 PEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLM 1293
            ||:|.:.|::...|||::|:|:|||.:.|.:||.|:..|:..|.::..|||..|:..||::|.||
 Frog   435 PESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELM 499

  Fly  1294 LQCWAADAESRPHFDEIY 1311
            .:||......||.|.||:
 Frog   500 RECWQWSPLDRPSFAEIH 517

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/89 (28%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/249 (42%)
abl1	XP_002936228.2	SH3_Abl	92..145	CDD:212784	8/55 (15%)
		SH2_ABL	150..243	CDD:198189	29/99 (29%)
		PTKc_Abl	262..524	CDD:270645	108/260 (42%)
		F_actin_bind	1003..1128	CDD:471692