DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and abl1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_002936228.2	Gene:	abl1 / 100490771	XenbaseID:	XB-GENE-6054675	Length:	1128	Species:	Xenopus tropicalis

Alignment Length:	538	Identity:	166/538 - (30%)
Similarity:	259/538 - (48%)	Gaps:	96/538 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   841 KQCTKRRRIHPSKSVFDFAKEFEV-------EQPAGSAADEQFCNCPPAGQKPVKPSVQISGHKD 898
            |:| :|::.....|.....|..|:       :...|.::... |....|.|:|....::..|
Frog     9 KKC-RRQQKGAGASCMQHMKMLEICLKLVGCKSKKGLSSSSS-CYLEEALQRPTVSDIEPQG--- 68

  Fly   899 HPFESSSGELDE----NSDRDIDNDEEEED-----------SASDDVLSMK----------DHC- 937
                     |.|    ||..::.:...|.|           ::.|:.||:.          :|.
Frog    69 ---------LSEAARWNSKENLLSGPSENDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNHNG 124

  Fly   938 -YC----------VPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNE 989
             :|          |||   :.....|.| .:..|:||.:.|.....||::  :|.|||||: .:.
Frog   125 EWCEAQTKNGQGWVPS---NYITPVNSP-EKHSWYHGPVSRNAAEYLLSSGINGSFLVRES-ESS 184

  Fly   990 ESQIVLSVCWNGH-KHFIVQTTGEGNFRFEGPP-FASIQELIMHQYHSELPVTVKSGAI--LRRP 1050
            ..|..:|:.:.|. .|:.:.|..:|........ |.::.||:.|  ||    ||..|.|  |..|
Frog   185 PGQRSISLRYEGRVYHYRINTASDGKLYVSSDSRFNTLAELVHH--HS----TVSDGLITTLHYP 243

  Fly  1051 VCR-------------ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCRM-TLPDE 1101
            ..:             ::||:...|:.:..::|.|.:|:||:...|...|.|||||.:. |:..|
Frog   244 APKRNKPTIYGVSPNYDKWEIERTDITMKHKLGGGQYGEVYEGVWKKYNLTVAVKTLKEDTMEVE 308

  Fly  1102 QKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK-NSNGLTTRQQMGM 1165
            :   ||:|..::|:..|||:|:|:|:|.::.|..|:.|.:..|:||.|||. |...:|....:.|
Frog   309 E---FLKEAAVMKEVKHPNLVQLLGVCTREPPFYIITEFMTYGNLLDYLRDCNRQEVTAVVLLHM 370

  Fly  1166 CRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTA 1228
            ....::.|.|||.||.||||||||||||...|.||::|||:||  ..:.|....|.| .|:||||
Frog   371 ATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTA 434

  Fly  1229 PEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLM 1293
            ||:|.:.|::...|||::|:|:|||.:.|.:||.|:..|:..|.::..|||..|:..||::|.||
Frog   435 PESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLEKDYRMERPEGCPEKVYELM 499

  Fly  1294 LQCWAADAESRPHFDEIY 1311
            .:||......||.|.||:
Frog   500 RECWQWSPLDRPSFAEIH 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/89 (28%)
		TyrKc	1063..1311	CDD:197581	104/251 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	105/249 (42%)
abl1	XP_002936228.2	SH3_Abl	92..145	CDD:212784	8/55 (15%)
		SH2_ABL	150..243	CDD:198189	29/99 (29%)
		PTKc_Abl	262..524	CDD:270645	108/260 (42%)
		F_actin_bind	1003..1128	CDD:385063
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910