DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and ntrk1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_002939035.2	Gene:	ntrk1 / 100489637	XenbaseID:	XB-GENE-923001	Length:	808	Species:	Xenopus tropicalis

Alignment Length:	372	Identity:	113/372 - (30%)
Similarity:	179/372 - (48%)	Gaps:	74/372 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   983 RETIRNEESQIVLSVCWNGHKHFI-----VQTTGEG-------NFRFEGPPF---ASIQELIMHQ 1032
            |..:..:|..:.:|:      ||:     ..|:.||       || .|.|.:   |.:|.
Frog   464 RAAVLAQEDDLAMSL------HFMNFGTSPLTSAEGKLDGMKPNF-IENPQYFCDACVQH----- 516

  Fly  1033 YHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKL-----KSTKLDVAVK 1092
                         |.||            |:||...:|.|.||.|:.|:.     ::.|..||||
Frog   517 -------------IKRR------------DIVLKWELGEGAFGKVFLAEFYNLTPENEKTLVAVK 556

  Fly  1093 TCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRK----- 1152
            ..: ...:..::.|.:|..:|....|.:|||..|:|...:|:::|.|.:..|.|..:||.
Frog   557 ALK-EATENARQDFQREAELLTVLQHEHIVKFYGVCTDGEPLIMVFEYMKHGDLNRFLRSHGPDA 620

  Fly  1153 ----NSNG-----LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSR 1208
                |.||     |...|.:.:....|:||.||.|.:.:|||||.|||||.....|||.||||||
Frog   621 KILDNGNGQPYGQLNLTQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGNNLVVKIGDFGMSR 685

  Fly  1209 E--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARE 1271
            :  ..:|....|...:|::|..||::.:.|:|:..|:||:|:::||||:.|..|:..::|:.|.|
Frog   686 DIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDIWSFGVVLWEIFTYGKQPWYQLSNTEAIE 750

  Fly  1272 RIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            .|..|.::..|::.|.|:|.:|..||..:.:.|.:..||:|.:.||:
Frog   751 CITQGRQLERPRTCPTEVYNIMQGCWQREPQQRLNIKEIHNKLQALV 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	14/70 (20%)
		TyrKc	1063..1311	CDD:197581	91/268 (34%)
		PTKc_Fes_like	1067..1315	CDD:270637	91/268 (34%)
ntrk1	XP_002939035.2	LRR_8	97..156	CDD:404697
		leucine-rich repeat	99..122	CDD:275378
		leucine-rich repeat	123..145	CDD:275378
		TPKR_C2	157..200	CDD:407151
		Ig	211..292	CDD:416386
		Ig strand B	219..228	CDD:409353
		Ig strand C	231..238	CDD:409353
		Ig strand C'	240..242	CDD:409353
		Ig strand D	245..253	CDD:409353
		Ig strand E	256..265	CDD:409353
		Ig strand F	272..279	CDD:409353
		Ig strand G	282..289	CDD:409353
		Ig	295..390	CDD:416386
		Ig strand A	296..302	CDD:409353
		Ig strand A'	304..307	CDD:409353
		Ig strand B	310..318	CDD:409353
		Ig strand C	321..328	CDD:409353
		Ig strand C'	331..334	CDD:409353
		Ig strand D	339..345	CDD:409353
		Ig strand E	352..360	CDD:409353
		Ig strand F	368..376	CDD:409353
		Ig strand G	379..387	CDD:409353
		PTKc_TrkA	516..795	CDD:270674	97/309 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910