DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and fes

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_002932286.2	Gene:	fes / 100489191	XenbaseID:	XB-GENE-6067138	Length:	822	Species:	Xenopus tropicalis

Alignment Length:	1329	Identity:	339/1329 - (25%)
Similarity:	509/1329 - (38%)	Gaps:	536/1329 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGFSSALQSRAAHEALIVRQDAELRLMETMKRSIQMKAKCDKEYAISLTAVAQQGLKIDRAD--- 62
            |||:..||....|.||:..||.|||||||||:....:||.||||:..|..::.|..|:|.:.
Frog     1 MGFAEELQCPNGHGALLRLQDVELRLMETMKKCFLQRAKSDKEYSNMLHHMSVQVDKLDHSPTPG 65

  Fly    63 -EMQGSLISKSWRSYMDELDHQAKQFKFNAEQLEV-VCDKLTHLSQDKRKARKAYQEEHAKIAAR 125
             ....|.:::||.:.:.:.::.::..:.::|.|.. ..:|||.|.::|::.:|:|.|:...:...
Frog    66 LSEYTSQLNESWATLVSQTENLSQILRKHSEDLNSGPLNKLTILIREKQQLKKSYSEQWQLLNQD 130

  Fly   126 LNHLTDEVVRK-KSEYQKHLEGYKALRTRFEENYIKAPSRSGRKLDDVRDKYQKACRKLHLTHNE 189
            ....|.:.:.| :|:|:..::.....:.:::|      :...:..|..::||.|...|||..||:
Frog   131 YIKTTQQDIEKLRSQYRSQVKETLQSKRKYQE------ACRDKDRDKAKEKYVKNTWKLHALHNQ 189

  Fly   190 YVLSITEA-IEVEKDFRNVLLPGLLEHQQSVQESFILLWRNILQEAAQYGDLTADKYKEIQKRID 253
            |||::..| :..|..|. ..||.|.|..||:.:..:.:.:||:||.::...|..::...:.:.|.
Frog   190 YVLAVKAAQLHHEHHFL-YSLPTLHESMQSIHQEMVQILKNIMQEYSEITSLVQEEVASLHREIA 253

  Fly   254 TVIGSINPTEEYGEFTEKYKTSPTTPLLFQFDETLIQ---DIPGKLQSSTLTVDNLTVDWLRNRL 315
            :.:.||:|.:||..|.:..::....|.:..||.:|::   |:..:||.:.|||::
Frog   254 SAVNSISPFKEYDNFLQMNRSVSELPPIVTFDTSLLEETDDLEEELQLNDLTVES---------- 308

  Fly   316 QELEGAVRDCQEKQMKMIEHVNGGSPVANGSIISNGSNTSNGIQSNKDSLCRQSKDLNALRCQEK 380
                             ::|                            :|....::|.::....:
Frog   309 -----------------VQH----------------------------TLTSVEEELASVTAAIE 328

  Fly   381 QKQKLVDMIKCALNEVGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRG 445
            .||   |::|...:::..||..:.|.:.:.|                             |.:|
Frog   329 GKQ---DIVKQLRSDIATEERTTDCREKINL-----------------------------LAKR- 360

  Fly   446 GVLTLLRGRGRHFKRKSTPQPATPMTRSRQGRFNKLQPRSQSLGSLSVIRDGNGPSPARYEPITN 510

Frog   361 ----------------------------------------------------------------- 360

  Fly   511 HRLRQAASVHYLGEEIATSSTNPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQLTAAVLTNT 575
            |.||.|                   |.:...|.|
Frog   361 HALRDA-------------------LLQYHMTLC------------------------------- 375

  Fly   576 NNNHIYADLE-LDKKKDT----SPSPECKGEQIQPKKEQIRIEINQTAPQNSIDAHLDRIDELNR 635
            |.|.|:...| |.:|.:|    .|.|
Frog   376 NKNKIHGQREKLKRKMNTIGSGDPPP--------------------------------------- 401

  Fly   636 VLDDRLKRTLQPSDDVNAIESAEENHIQTRKLAKDPDSQTKRSSSSSSECRSSKDTSHSKKRSLS 700
                    .||..||..:|.|.|.                        ||
Frog   402 --------ALQLQDDNQSISSVER------------------------EC--------------- 419

  Fly   701 FSQKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNN 765
             .:|::.||                ||||                  ||...|
Frog   420 -GKKTLENI----------------KNHI------------------SGIFRP------------ 437

  Fly   766 NNKNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLL 830
                                                      ||.:|.:
Frog   438 ------------------------------------------KFSLPPL---------------- 444

  Fly   831 NFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISG 895
                                                                  .|:.|.||
Frog   445 ------------------------------------------------------LPLIPDVQ--- 452

  Fly   896 HKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEW 960
                                                                     :||.::.|
Frog   453 ---------------------------------------------------------KPLSQQNW 460

  Fly   961 FHGVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRFEGPPFAS 1024
            :||.:||.||..||.|:||||:||:...:|  .||||.|.|. :|||:|.. :..:|.||..|::
Frog   461 YHGAIPRSEVQGLLVNNGDFLIRESQGKQE--YVLSVLWEGQPRHFIIQNV-DNCYRLEGEGFST 522

  Fly  1025 IQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDV 1089
            |..||.|...::..||.|||.||.:.|.:::|.|.:::|:|.||||:||||:|:..:|::....|
Frog   523 IPLLIDHFLKTKQAVTKKSGVILNKAVVKDKWVLEHEEVILGERIGKGNFGEVFSGRLRADNTPV 587

  Fly  1090 AVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNS 1154
            |||:||.|||.:.|.|||.|.||||||.|||||||||:|.||.||.||||||.||...|:||...
Frog   588 AVKSCRDTLPPDLKDKFLMEARILKQYSHPNIVKLIGVCTQKHPIYIVMELVQGGDFQTFLRNEG 652

  Fly  1155 NGLTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE--YIVSD 1217
            ..|..::.:.|..:|||||.|||||:|||||||||||||..::.:||||||||||||:  |..:.
Frog   653 PKLKVKELIRMSENAAAGMEYLESKHCIHRDLAARNCLVTEKNVLKISDFGMSREEEDGVYSSTG 717

  Fly  1218 GMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTP 1282
            ||||||||||||||||:|:|:|..||||:|:|:||.||.|..||:.|:|.:.||.|:.|.|:..|
Frog   718 GMKQIPVKWTAPEALNYGRYSSESDVWSFGVLLWEAFSLGSVPYATMSNQQTREIIEQGIRLLVP 782

  Fly  1283 KSTPEEMYRLMLQCWAADAESRPHFDEIY 1311
            .:.|:|:|.|||:||..|.:.||:|..::
Frog   783 DNCPDEVYSLMLRCWEYDPKKRPNFSTVH 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341	70/242 (29%)
		SH2_Fps_family	953..1039	CDD:198224	37/86 (43%)
		TyrKc	1063..1311	CDD:197581	147/249 (59%)
		PTKc_Fes_like	1067..1315	CDD:270637	145/247 (59%)
fes	XP_002932286.2	F-BAR_Fes	7..243	CDD:153369	70/242 (29%)
		SH2_Fps_family	453..537	CDD:198224	37/86 (43%)
		PTKc_Fes	564..815	CDD:270667	145/248 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	311	1.000	Domainoid score	I1304
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	564	1.000	Inparanoid score	I1074
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D255116at33208
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm49294
Panther	1	1.100	-	-	LDO	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3894
SonicParanoid	1	1.000	-	-		X1749
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	10.100