DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and map3k10

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_002938858.3	Gene:	map3k10 / 100488058	XenbaseID:	XB-GENE-920944	Length:	990	Species:	Xenopus tropicalis

Alignment Length:	395	Identity:	107/395 - (27%)
Similarity:	166/395 - (42%)	Gaps:	94/395 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   976 NDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGN------FRFEGPPFASIQELIMHQ-- 1032
            |:| ||.:.:..|:|:.:     ||.     ||:.|..|      |.:|.   .:.:||.:|:
Frog     8 NEG-FLWQSSKDNKENGV-----WNE-----VQSYGVSNPLWMAVFDYEA---TAEEELTLHRGD 58

  Fly  1033 ---------------------------------YHSELPVTVKSGAILRRPVCRERWELSNDDVV 1064
                                             ..|:...|..:||..:.|:   ..|:..:::.
Frog    59 LVEILSKDSTVSGDEGWWTGKIKDKVGIFPSNYVVSDNKYTTLTGAPKQCPL---PLEIEFEELN 120

  Fly  1065 LLERIGRGNFGDVYKAKLKSTKLDVAVKTCRMTLPDEQ----KRKFLQEGRILKQYDHPNIVKLI 1125
            |.|.||.|.||.|||...:..  :||||..|.. |||.    .....||.::.....||||:.|.
Frog   121 LEEIIGVGGFGKVYKGLWRGD--EVAVKAVRHD-PDEDINVTAENVRQEAKLFCMLCHPNIIALK 182

  Fly  1126 GICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESK---NCIHRDLA 1187
            |:|::...:.:|||...||.|...|.  ...:.....:......|.||.||.::   ..|||||.
Frog   183 GVCLKPPHLCLVMEYARGGPLHRALA--GKKVPAHVLVNWAVQIARGMNYLHNEAIVPIIHRDLK 245

  Fly  1188 ARNCLV--DLEH------SVKISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVW 1244
            :.|.|:  .:||      ::||:|||::||.::........  ...|.|||.:....::...|||
Frog   246 SSNILILEKVEHDDLFNKTLKITDFGLAREWQKTTKMSAAG--TYAWMAPEVIRLSLFSKSSDVW 308

  Fly  1245 SYGILMWEIFSKGDTPYSGMTNSRARERIDTGY-------RMPTPKSTPEEMYRLMLQCWAADAE 1302
            |:|:|:||:.: |:.||      |..:.:...|       .:|.|.:.||...|::..||..|..
Frog   309 SFGVLLWELLT-GEVPY------REIDALAVAYGVAMNKLTLPIPSTCPEPFVRILEACWDPDPH 366

  Fly  1303 SRPHF 1307
            |||.|
Frog   367 SRPSF 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	18/103 (17%)
		TyrKc	1063..1311	CDD:197581	84/267 (31%)
		PTKc_Fes_like	1067..1315	CDD:270637	83/263 (32%)
map3k10	XP_002938858.3	SH3_MLK1-3	37..94	CDD:212992	5/59 (8%)
map3k10	XP_002938858.3	STKc_MLK2	124..381	CDD:271050	82/262 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910