DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and epha7

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_031758138.1	Gene:	epha7 / 100486526	XenbaseID:	XB-GENE-488635	Length:	1062	Species:	Xenopus tropicalis

Alignment Length:	827	Identity:	200/827 - (24%)
Similarity:	324/827 - (39%)	Gaps:	259/827 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   698 SLSFSQKSISNIFSNL---------KEFSKSPLVRMGKNHILNEEQDAKRTQPSQH--------- 744
            |:....|...:|..||         .|||.  ||.:....:.|.|::|..: |..|
Frog   196 SVKVYYKKCWSIIENLAIFPDTVTGSEFSS--LVEVRGTCVTNAEEEADNS-PRMHCSAEGEWLV 257

  Fly   745 -------------------------HHSSGSD-----CPTNSSSSSSNNN------------NNN 767
                                     :.||..|     ||.:|.|....::            ::.
Frog   258 PIGKCICQAGYQQKGDTCEPCGRGFYKSSSQDLQCSRCPAHSFSDKEGSSRCDCEDGYYRAFSDP 322

  Fly   768 KNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSK-------AIRNTF 825
            ...:.....||.|:.|.  .|..|..:...:.|:....|.......:.|:..       ...||.
Frog   323 PYIACTRPPSAPQNLIY--NINQTTVSLEWSPPADNGGRSDVTYRVVCKRCSWEQGECIPCANTI 385

  Fly   826 -----RSKLLN---------------FQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGS 870
                 :|.|::               |:::........::.:|:..:.||......::    .|.
Frog   386 GYVPQQSGLVDTYISIVDLVAHANYTFEVEAVNGVSDLSRSQRLFAAVSVTTGQAVYK----EGL 446

  Fly   871 AADEQFCNCPP------AGQKPVKPSVQISG----------------HKDHPFESSSGELDENSD 913
            :...|:.|.|.      :|:.|    .|:||                ..:||    :|.:.|...
Frog   447 SRSMQYGNHPSYVEMQISGEAP----SQVSGVMKERVLQRAVDLSWQEPEHP----NGVITEYEI 503

  Fly   914 RDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRP----LYEEEWF----HGVL-PREE 969
            :..:.|:.|...::            :.:.:.|:|::..||    :::...|    :|:. ||.:
Frog   504 KYYEKDQRERTYST------------LKTKSTSVSINNLRPGTAYIFQIRAFTAAGYGMYSPRLD 556

  Fly   970 VVRLLNNDGDFLVRETIRNEESQI----VLSVCWN------------GHKHF-IVQTTGEG---- 1013
            |..|     :......:..|::.:    |::|...            |.:|. ..:...||
Frog   557 VSTL-----EEATATAVSTEQNPVIIIAVVAVAGTIILVFMVFGFIIGRRHCGYSKADQEGDEEL 616

  Fly  1014 --NFRFEG------PPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLER-I 1069
              :|:|.|      |.........:||:..||..:           |           :.:|| |
Frog   617 YFHFKFPGTKTYIDPETYEDPNRAVHQFAKELDAS-----------C-----------IKIERVI 659

  Fly  1070 GRGNFGDVYKAKLK---STKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQK 1131
            |.|.||:|...:||   ...:.||:||.::...::|:|.||.|..|:.|:||||:|.|.|:..:.
Frog   660 GAGEFGEVCSGRLKLPGKRDVPVAIKTLKVGYTEKQRRDFLCEASIMGQFDHPNVVHLEGVVTRG 724

  Fly  1132 QPIMIVMELVLGGSLLTYLRK-----------------------------------NSNG----- 1156
            :|:|||:|.:..|:|..:||:                                   |:.|
Frog   725 KPVMIVIEFMENGALDAFLRQQQKKGKNCLEWFTSPPKSKRSGSTQTMPFVKVQTLNTPGTNAQK 789

  Fly  1157 ----LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGMSREEEE----- 1212
                .|..|.:||.|..|||||||.....:||||||||.||:.....|:||||:||..|:
Frog   790 LDGQFTVIQLVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRIIEDDPDAV 854

  Fly  1213 YIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGY 1277
            |..:.|  :|||:||||||:.:.|:||..|||||||:|||:.|.|:.||..|:|....:.|:.||
Frog   855 YTTTGG--KIPVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEGY 917

  Fly  1278 RMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRLDNS 1324
            |:|.|...|..:::|||.||..:...||.|::|..::|.:| |..||
Frog   918 RLPAPMDCPAGLHQLMLDCWQKERGERPKFEQIVGILDKMI-RNPNS 963

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	23/123 (19%)
		TyrKc	1063..1311	CDD:197581	114/300 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	115/300 (38%)
epha7	XP_031758138.1	EphR_LBD_A7	29..205	CDD:198453	2/8 (25%)
		Ephrin_rec_like	274..311	CDD:400166	7/36 (19%)
		FN3	331..420	CDD:214495	14/90 (16%)
		FN3	468..559	CDD:238020	19/110 (17%)
		EphA2_TM	585..650	CDD:405290	12/64 (19%)
		PTKc_EphR_A	648..958	CDD:270651	118/333 (35%)
		SAM_EPH-A7	983..1052	CDD:188947
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910