DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and si:ch73-340m8.2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_002665190.3	Gene:	si:ch73-340m8.2 / 100332982	ZFINID:	ZDB-GENE-110411-209	Length:	480	Species:	Danio rerio

Alignment Length:	487	Identity:	146/487 - (29%)
Similarity:	223/487 - (45%)	Gaps:	63/487 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   877 CNCPPAGQKPVKP-----SVQISGHKDHPFESSSG---------ELDENSDRDIDNDEE------ 921
            |.|.|....|..|     ..|.|.::|..:.|...         .|.:....::..:.|
Zfish     4 CECKPKCCCPCCPCCLTKDQQASVNRDRVYTSIYSYPSRTIWDLNLRKGDILEVTGETEYWLYVR 68

  Fly   922 EEDSASDDVLS-MKDHCYCVPSLAASISLSTNRPLYEEEWFHGVLPREEVVRLL----NNDGDFL 981
            ...:.:|...| :::|.|........:......|.|    |..|..|.|..|.|    |.:|.||
Zfish    69 RRTAKTDKSKSFIEEHGYVPKDFVKPLDSVEAEPWY----FENVKTRVEAKRCLLRPENKEGAFL 129

  Fly   982 VRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRF---EGPPFASIQELIMHQYHSE----LP 1038
            |.:.  :|.:...|||....| :|:.:: .||.:.:|   ....|.|:::||  :::|:    |.
Zfish   130 VWKC--DENNHYYLSVKNGPHARHYRIK-QGENDQQFFLVHHTTFQSLRKLI--EFYSKHEGGLC 189

  Fly  1039 VTVKSGAI-LRRPVCR-----ERWELSNDDVVLLERIGRGNFGDVYKAKLKSTKLDVAVKTCR-M 1096
            ..:....: |.:||.:     .:.|:....:...:::|.|.|.||::....:| .:||:|..: :
Zfish   190 AKLHEACVKLDQPVPQTLSFDSKCEIDRSSLTKQQKLGSGEFADVWQGLWNNT-TEVAIKEFKGV 253

  Fly  1097 TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYL--RKNSNGLTT 1159
            ...|.|     .|..|:|...|..::||..:|...||:.||.||:..|||.|:|  .|....|..
Zfish   254 NYSDIQ-----TEIEIMKDLHHERLLKLYAVCTTSQPMCIVTELMKNGSLKTFLLRHKEKQDLEF 313

  Fly  1160 RQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGM---SREEEEYIVSDGMKQ 1221
            ...:........||.|:|:| .:||||.|.|.|:....|.||:|||:   :|...:.|.||  .:
Zfish   314 SLMLDFAIQITEGMIYIENK-IVHRDLRAENILLTEMQSCKIADFGLAQVNRPGNQRISSD--VR 375

  Fly  1222 IPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTP 1286
            :||||.|||..:.|:|||..||||:|||:.||.:.||.||.|.........|..|.|||.|...|
Zfish   376 LPVKWMAPEIFDNGEYTSKSDVWSFGILLTEIVTYGDDPYPGQDKMSCVRGIQRGERMPRPAGCP 440

  Fly  1287 EEMYRLMLQCWAADAESRPHFDEIYNVVDALI 1318
            |.:|.:||.||.|:.:.||.|.|:..::.|||
Zfish   441 ESLYGIMLLCWKANPKERPTFTELREMLMALI 472

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	28/97 (29%)
		TyrKc	1063..1311	CDD:197581	96/253 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	96/253 (38%)
si:ch73-340m8.2	XP_002665190.3	SH2	99..192	CDD:301589	28/101 (28%)
		Pkinase_Tyr	220..468	CDD:285015	96/256 (38%)
		PKc_like	225..468	CDD:304357	96/251 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.000