DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and shc3

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_021324876.1	Gene:	shc3 / 100332111	ZFINID:	ZDB-GENE-130312-2	Length:	632	Species:	Danio rerio

Alignment Length:	745	Identity:	144/745 - (19%)
Similarity:	234/745 - (31%)	Gaps:	276/745 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   396 VGCEELPSGCDDDLTLEQNFIENGYNNEQQRSNSTSSPGLGIMNELMRRGGVLTLLRGRGRHFKR 460
            :|.:.|||...|   |..:.::.|     ..:.::|||.
Zfish    79 LGIKGLPSAVKD---LAVSKLQGG-----AAAGASSSPA-------------------------- 109

  Fly   461 KSTPQPATPM-----TRSRQGRFNKLQPRSQ--SLGSLSVIRDG---NGPSPA---RYEPITNHR 512
            .||...|:|:     :..::||..:.||..:  |||.......|   |.||..   ..|.|:...
Zfish   110 SSTLAAASPLEPGSTSSGKKGRMEESQPSGEGWSLGGTGAAGCGGLVNKPSHGWLHSSEKISGPG 174

  Fly   513 LRQAASVHYLG-EEIATSS-----TNPPDLTRLRRTQC----------SMLCLGED----EEPVV 557
            :...  |.||| .|:..|.     |....:||...|.|          ...|...:    :.|.:
Zfish   175 VTYV--VKYLGCIEVLRSMRSLDFTTRSQITRYEHTLCIHTQKTLKDLKQSCCAMNGLYAQCPSL 237

  Fly   558 LASPAPLTQLTAAVLTNTNNNHIYADLELDKKKDTSP----SPECKGEQIQPKKEQIRIEINQTA 618
            ..:|   ::|.:::|..:|..  :|.:.::....||.    :|:.|  ||........|......
Zfish   238 FQTP---SKLLSSILGKSNLQ--FAGMSINLNISTSSLNLMTPDSK--QIIANHHMQSISFASGG 295

  Fly   619 --------------PQNSIDAHL---------DRIDELNRVLDDRLKRTLQ-PSDDVNAI----- 654
                          |.|....|:         |.|..:.:..|.|.:..|| ||...::|
Zfish   296 DPDTTDYVAYVAKDPVNRRACHILECSDGLAQDVISTIGQAFDLRFQLYLQCPSSKPSSIHDRVM 360

  Fly   655 -----------ESAEENHIQTRKLAKDP------DSQTKRSSSSSSECRSSKDTSHSKKRSLSFS 702
                       :...::|.......|.|      |::....|..||: .:..|.::.:.|.: |.
Zfish   361 STDEPPWTEEGDETADHHYYNSIPGKMPPPGGFIDARLTNQSQDSSQ-GAGVDQTYYQGRPM-FI 423

  Fly   703 QKSISNIFSNLKEFSKSPLVRMGKNHILNEEQDAKRTQPSQHHHSSGSDCPTNSSSSSSNNNNNN 767
            |:...:|:| |.|....|                          ....:.|
Zfish   424 QQGSCDIYS-LPEVKAQP--------------------------PKAGEVP-------------- 447

  Fly   768 KNTSSNSNHSASQSTIITSTITTTITTTTTTTPSKENSRLKFKVPKIQKKSKAIRNTFRSKLLNF 832
              |..|:.|..:|........|.|...::||...|::
Zfish   448 --TYVNTQHIDTQVLAALQAETETNADSSTTGAPKDS---------------------------- 482

  Fly   833 QLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQKPVKPSVQISGHK 897
                              |.|.:||. |.||         |......|.|.:.          ||
Zfish   483 ------------------PRKDLFDM-KPFE---------DAIMTQTPAASEL----------HK 509

  Fly   898 DHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAASISLSTNRPLYEEEWFH 962
            ....::||                                   |.|..:.:|..:..|.::.|:|
Zfish   510 AASVDNSS-----------------------------------PLLMRAAALRAHEELEDQRWYH 539

  Fly   963 GVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEGNFRFEGPPFASIQE 1027
            |.:.|.:..:||.:|||||||::..|..| .||:...||....::....||..|.:...|.||..
Zfish   540 GEMSRRQAEKLLLHDGDFLVRKSTTNPGS-YVLTGMHNGLAKHLLLVDPEGTVRTKDHIFESISH 603

  Fly  1028 LIMHQYHSELPVTVKSGA--ILRRPVCRER 1055
            ||.|...:.||: |.:|:  .|::||.|::
Zfish   604 LIGHHRDNNLPI-VSAGSELCLKQPVDRKQ 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/85 (35%)
		TyrKc	1063..1311	CDD:197581
		PTKc_Fes_like	1067..1315	CDD:270637
shc3	XP_021324876.1	PTB_Shc	162..346	CDD:269920	34/192 (18%)
shc3	XP_021324876.1	SH2_SHC	530..632	CDD:198179	37/103 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910