DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and mertka

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_002664277.3	Gene:	mertka / 100322133	ZFINID:	ZDB-GENE-081107-1	Length:	952	Species:	Danio rerio

Alignment Length:	988	Identity:	213/988 - (21%)
Similarity:	349/988 - (35%)	Gaps:	295/988 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   472 RSRQGRFNKLQPR-----SQSLGSLSVIRDGNGPSPARYEPITNHRLRQAASVHYLGEEIATSST 531
            :|....|..|.|.     |||:...:.:.....|....:...::|..||..|
Zfish     7 KSFSAMFRFLTPLLLGLFSQSVSLTTAVVSMKHPLAVVHHEGSSHWARQGRS------------- 58

  Fly   532 NPPDLTRLRRTQCSMLCLGEDEEPVVLASPAPLTQL------------TAAVLTNTNNNHIYADL 584
                   .|.|..|        ||:::.:.||...|            |...:..:....::.:.
Zfish    59 -------FRPTHAS--------EPLMVPARAPSVHLSQEEIQRLRFKPTVGTIQRSEGAEVHFNC 108

  Fly   585 ELDKKKDTSPSPEC----KGEQIQPK-------------KEQIRIEINQTAPQNSIDAHLD---- 628
            .:| ..|.|.....    .|::|...             :..|.|:..|.|........|.
Zfish   109 SID-INDVSQDLNILWFRNGKEIHDSMQTAISTQGTVSLQSTISIKSVQRADAGEYHCRLSVSNK 172

  Fly   629 --RIDELNRVLDDRLKRTLQPSDDVNAIES----------AEENHIQTRKLAKDPDSQTKR---S 678
              ..:.:|.|::......:||| |||...:          ...|.:..:.|.|.     ||   |
Zfish   173 FIESNSINLVVEGLPTFIIQPS-DVNITRNTPFTLTCEAVGPPNPVTIKWLHKG-----KRFLES 231

  Fly   679 SSSSS-------------ECRSSKDTSHSKKRSLSFSQKSISNIFSNLKEFSKSPLVRMGKNHIL 730
            :.|||             .|.     :|::| .|:.|:::..||....::.||..:|:...|.:|
Zfish   232 NQSSSIIPIEGVDAPTQFSCE-----AHNEK-GLTASREAHINIKELPEKVSKVTVVKREANKLL 290

  Fly   731 NEEQDAKRTQPSQHHHS------------SGSDCPTNSSSSS-----SNNNNNNKNTSSNSNHSA 778
                  ....|.....|            .|:..||.:.|::     ...||....|..|.:.|.
Zfish   291 ------LSWTPGHDGFSPLSICYIAVRELQGAGSPTAAHSTAVPPFQYEINNLKAMTWYNMSVSC 349

  Fly   779 SQSTIITSTITTTITTTTTTTPSK---------ENSRL--KFKVPKIQKKSKAIR---------- 822
            |.....:.......:.||...||:         .||.|  :::.|...|.:..::
Zfish   350 SNEIGPSPPSAWVQSNTTEGVPSEAPQNLTVQLNNSMLIIRWEAPPPDKLNGILQGYDVTIKHGT 414

  Fly   823 --NTFRSKLLNFQLKRSKPCKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNCPPAGQK 885
              ||.||                   .....:.::.:|...:.||..|        |.....|.|
Zfish   415 HTNTIRS-------------------MSTEAAVTLQEFNSTYSVEVVA--------CTHSGCGTK 452

  Fly   886 P-----VKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLAA 945
            .     |.||:      |.|...||..|....|            ::..||.:....:.|..|..
Zfish   453 RSRHWLVVPSI------DSPDSPSSTPLPNRPD------------SAFIVLGVVCGFFLVIVLCW 499

  Fly   946 SISLSTNRPLYEEEWFH--GVLPREEVVRLLNNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQ 1008
            .:            |.|  ..||                               ||.|....:..
Zfish   500 VV------------WLHNNSYLP-------------------------------CWFGADDKLTP 521

  Fly  1009 TTGEGNFRFEGPPFASIQELIMHQYHSELPVTVKSGAILRRPVCRERWELSNDDVVLLER----- 1068
            ..       |..|..|..       .|.:.:|:.|..|      ....:....||:::..
Zfish   522 IV-------EYKPQRSYN-------RSAIEITLASLGI------SSELQAKLQDVMIVRNLLSIG 566

  Fly  1069 --IGRGNFGDVYKAKLK----STKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIG 1126
              :|.|.||.|.:..|:    ||: .|||||.:: .....:..:||.|...:|.:.|||::||:|
Zfish   567 KVLGEGEFGSVMEGHLRQPDGSTE-KVAVKTMKLDNFSQREIEEFLNEAACMKDFHHPNVIKLLG 630

  Fly  1127 ICVQ------KQPIMIVMELVLGGSLLTYLRKNSNG-----LTTRQQMGMCRDAAAGMRYLESKN 1180
            :|::      .:| |:|:..:..|.|.:||.::.:|     |..:..:....|.|.||.||.|:|
Zfish   631 VCLEVGSGHFPKP-MVVLPFMKYGDLHSYLLRSRHGEDTVYLPMQMLLKFMIDIALGMEYLSSRN 694

  Fly  1181 CIHRDLAARNCLVDLEHSVKISDFGMSRE--EEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDV 1243
            .:|||||||||::..:.||.::|||:|::  ..:|.....:.::||||.|.|:|....:|...||
Zfish   695 FLHRDLAARNCMLRDDMSVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAVESLADRVFTVKSDV 759

  Fly  1244 WSYGILMWEIFSKGDTPYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFD 1308
            |::|:.||||.::|.|||.|:.|....:.:..|.|:..|....:|:|.:|..||:.:...||.|.
Zfish   760 WAFGVTMWEIATRGMTPYPGVQNHEIYDYLLEGNRLKQPNDCLDELYDIMFSCWSNEPVDRPDFT 824

  Fly  1309 EIYNVVDALILRL 1321
            ::...::.|..:|
Zfish   825 QVRKRLETLSAKL 837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	11/87 (13%)
		TyrKc	1063..1311	CDD:197581	91/272 (33%)
		PTKc_Fes_like	1067..1315	CDD:270637	90/272 (33%)
mertka	XP_002664277.3	IG_like	94..183	CDD:214653	11/89 (12%)
		IGc2	100..166	CDD:197706	9/66 (14%)
		I-set	187..270	CDD:254352	21/94 (22%)
		Ig	189..268	CDD:299845	20/90 (22%)
		FN3	273..366	CDD:238020	17/98 (17%)
		FN3	374..450	CDD:214495	14/102 (14%)
		PTKc_Mer	555..838	CDD:271106	94/285 (33%)
		Pkinase_Tyr	563..830	CDD:285015	90/268 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910