DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and csk

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001135615.1	Gene:	csk / 100216174	XenbaseID:	XB-GENE-5771921	Length:	450	Species:	Xenopus tropicalis

Alignment Length:	367	Identity:	135/367 - (36%)
Similarity:	193/367 - (52%)	Gaps:	34/367 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   960 WFHGVLPREEVVRLL--NNDGDFLVRETIRNEESQIVLSVCWNGH-KHF-IVQTTGEGNFRFEGP 1020
            ||||.:.||:..|||  ...|.|||||: .|......|.|...|. :|: |:.::|:.:.. |..
Frog    82 WFHGKITREQAERLLYPPETGLFLVRES-TNYPGDYTLCVSCEGKVEHYRIIYSSGKLSID-EEE 144

  Fly  1021 PFASIQELIMHQYHSEL---------PVTVKSGAILRRPVCRERWELSNDDVVLLERIGRGNFGD 1076
            .|.::.:|:.| |.::.         |..|:.....:....|..|.|...|:.||..||:|.|||
Frog   145 YFENLMQLVEH-YTNDADGLCTNLMKPKLVEGTVAAQDEFSRSGWALKMRDLKLLHTIGKGEFGD 208

  Fly  1077 VYKAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQ-KQPIMIVMEL 1140
            |...:.:..|  ||||..:   .|...:.|:.|..::.|..|.|:|:|:|:.|: |..:.||.|.
Frog   209 VMLGEHQGVK--VAVKCIK---NDATAQAFVAEAMVMTQLQHNNLVQLLGVIVEDKSGLFIVTEF 268

  Fly  1141 VLGGSLLTYLRKNSNGLTTRQQMGMC-----RDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVK 1200
            :..|||:.|||.....:..    |.|     .|.:.||.||||.|.:||||||||.||..|:..|
Frog   269 MAKGSLVDYLRSRGRSVLG----GECLLKFSLDVSEGMAYLESNNFVHRDLAARNVLVSEENIAK 329

  Fly  1201 ISDFGMSREEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMT 1265
            :||||:::|..  .:.|..| :||||||||||....:::..||||:|||:|||:|.|..||..:.
Frog   330 VSDFGLTKEAS--AIQDTSK-LPVKWTAPEALRDKLFSTKSDVWSFGILLWEIYSFGRVPYPRIA 391

  Fly  1266 NSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHF 1307
            ......:::.||:|..|...|..:|.||.|||..|.:.||.|
Frog   392 LKDVVPKVENGYKMDAPDGCPPVVYDLMKQCWHLDPKQRPTF 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	27/91 (30%)
		TyrKc	1063..1311	CDD:197581	102/251 (41%)
		PTKc_Fes_like	1067..1315	CDD:270637	100/247 (40%)
csk	NP_001135615.1	SH3_CSK	11..67	CDD:212703
		SH2_csk_like	78..175	CDD:198190	29/95 (31%)
		PKc_like	188..443	CDD:389743	105/258 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910