DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and srms

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	NP_001129722.2	Gene:	srms / 100192213	ZFINID:	ZDB-GENE-081022-95	Length:	492	Species:	Danio rerio

Alignment Length:	511	Identity:	152/511 - (29%)
Similarity:	255/511 - (49%)	Gaps:	62/511 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   840 CKQCTKRRRIHPSKSVFDFAKEFEVEQPAGSAADEQFCNC-PPAGQKPVKPSVQISGHKDHPFES 903
            |..|.||        ::|            |...|.:.|. .|...:.|...:::...|..|.:.
Zfish     8 CMPCLKR--------LWD------------SIWPENYPNLHRPDDIRTVSGDIRVPAPKKKPAQL 52

  Fly   904 SSGELDENSDRDIDNDEEEEDSASDDVLSM----KDHCYC---VPSLAASISLSTNRPLYEEE-- 959
            .:...|     .:...|||......|.||:    .|:.:.   ..||.:.:..:....|.::|
Zfish    53 YAALFD-----FVARSEEELSVKEGDKLSVIEKRGDYVFAKKLTGSLESGLIPANYVALLKDEFA 112

  Fly   960 ---WFHGVLPREEVVRLL----NNDGDFLVRETIRNEESQIVLSVCWNGHKHFIVQTTGEG-NFR 1016
               |::|.:.|::..:||    |..|.||||.:..:.:...:.:...|...||.:..:..| .|.
Zfish   113 NYKWYYGNINRQKAEKLLLSSENKTGSFLVRISESHSDEYTISARSENSVFHFRIHRSPIGAYFV 177

  Fly  1017 FEGPPFASIQELIMH--QYHSELPVTVKSGAILRRPVC-RERWELSNDDVVLLERIGRGNFGDVY 1078
            .|...|.::.|||.:  |....|...:....:.||.:. .|.||...::.:|::::|.|:||:|:
Zfish   178 SEKISFGTLDELIRYYQQNSRSLGCHIDQPCVQRRELFDMEPWERPREEFMLVKKLGEGHFGEVW 242

  Fly  1079 KAKLKSTKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIVMELVLG 1143
            :|..|:.|..||:|..:.  .|.:..:|::|...||...||.:::|:.:|.:.:|:.||.||:..
Zfish   243 EAIWKTQKKKVAIKMLKQ--EDTKLDEFVKEVHALKNLHHPKLIELLALCSRGEPVYIVTELMAK 305

  Fly  1144 GSLLTYLRKNSNG--LTTRQQMGMCRDAAAGMRYLESKNCIHRDLAARNCLVDLEHSVKISDFGM 1206
            |||.:|| .::.|  ||:...:.|....|.||.|||.::.:||||||||.||..:...|::|||:
Zfish   306 GSLKSYL-SSAEGQLLTSAHLIYMAAQIAEGMAYLEDRHIVHRDLAARNILVGNDLVCKVADFGL 369

  Fly  1207 SREEEEYIVSDGM------KQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDTPYSGMT 1265
            :|     |:.|.:      .:|||:||||||..:.:::...||||:|:|::|:.|:|..||.|.|
Zfish   370 AR-----IIKDSVFTASKTTKIPVRWTAPEAALYQRFSVKSDVWSFGVLLYEMMSRGKMPYDGKT 429

  Fly  1266 NSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDALILRL 1321
            |....|.:.:|||:..|...|..:||:||:||..:|..||.|..:::.:|.:..||
Zfish   430 NKEVMEALSSGYRLACPNHCPPNIYRIMLECWNNEASKRPSFHALHSQLDNIYSRL 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/97 (26%)
		TyrKc	1063..1311	CDD:197581	97/255 (38%)
		PTKc_Fes_like	1067..1315	CDD:270637	96/255 (38%)
srms	NP_001129722.2	SH3	52..106	CDD:302595	10/58 (17%)
		SH2	114..197	CDD:214585	22/82 (27%)
		PKc_like	220..481	CDD:304357	100/268 (37%)
		STYKc	229..478	CDD:214568	97/256 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910