DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and tnk2

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_031757304.1	Gene:	tnk2 / 100124754	XenbaseID:	XB-GENE-984470	Length:	1151	Species:	Xenopus tropicalis

Alignment Length:	266	Identity:	98/266 - (36%)
Similarity:	149/266 - (56%)	Gaps:	24/266 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly  1058 LSNDDVVLLERIGRGNFGDVYKAKLKSTK---LDVAVKTCR---MTLPDEQKRKFLQEGRILKQY 1116
            :|..|:.:.|::|.|:||.|.:.:..:..   .:||||..:   :|.||... .|::|...:...
Frog   144 ISEKDLSMFEKLGDGSFGVVRRGEWNTPNGKLFNVAVKCLKTDVLTQPDVLD-DFIREVNAMHSL 207

  Fly  1117 DHPNIVKLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNG--LTTRQQMGMCRDA---AAGMRYL 1176
            ||.|:::|.|: |...|:.:|.||...||||..||||...  ::|     :|..|   |.||.||
Frog   208 DHINLIRLYGV-VLTHPMKMVTELAPMGSLLDRLRKNQGYFLIST-----LCHYAIQIANGMAYL 266

  Fly  1177 ESKNCIHRDLAARNCLVDLEHSVKISDFGMSR----EEEEYIVSDGMKQIPVKWTAPEALNFGKY 1237
            |||..|||||||||.|:.....|||.|||:.|    .::.|::.:..| :|..|.|||:|....:
Frog   267 ESKRFIHRDLAARNILLSSNDLVKIGDFGLMRALPKNDDHYVMQEHRK-VPFAWCAPESLKTRTF 330

  Fly  1238 TSLCDVWSYGILMWEIFSKGDTPYSGMTNSRARERID-TGYRMPTPKSTPEEMYRLMLQCWAADA 1301
            :...|.|.:|:.:||:|:.|..|:.|:..|:...:|| .|.|:..|:.:|:::|.:||||||...
Frog   331 SHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLVRPEDSPQDIYNVMLQCWAHKP 395

  Fly  1302 ESRPHF 1307
            |.||.|
Frog   396 EDRPTF 401

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224
		TyrKc	1063..1311	CDD:197581	96/261 (37%)
		PTKc_Fes_like	1067..1315	CDD:270637	96/257 (37%)
tnk2	XP_031757304.1	SAM_TNK-like	34..95	CDD:188938
		PTKc_Ack_like	153..410	CDD:270636	96/257 (37%)
		SH3_9	418..467	CDD:405311
		GTPase_binding	472..533	CDD:401099
		Inhibitor_Mig-6	883..947	CDD:402933
		UBA_ACK1	1074..1115	CDD:270460
		UBA_TNK1	1102..1141	CDD:270513
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910