DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment FER and abl1

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_005172104.1	Gene:	abl1 / 100000720	ZFINID:	ZDB-GENE-100812-9	Length:	1081	Species:	Danio rerio

Alignment Length:	513	Identity:	155/513 - (30%)
Similarity:	248/513 - (48%)	Gaps:	101/513 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   886 PVKPSVQISGHKDHP-----------FESSSGELDE---------NSDRDIDNDEEEED------ 924
            |..|.::.:|.::.|           ...|..:.|.         ||..::.:...|.|
Zfish    18 PALPFIKAAGRRETPRHGAPHCNVFTVHESRPDFDPPGLSEAARWNSKENLLSGPSENDPNLFVA 82

  Fly   925 -----SASDDVLSMK----------DHC--YC----------VPSLAASISLSTNRPLYEEEWFH 962
                 ::.|:.||:.          :|.  :|          ||    |..::....|.:..|:|
Zfish    83 LYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQGWVP----SNYITPVNSLEKHSWYH 143

  Fly   963 GVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNGH-KHFIVQTTGEGNFRFEGPP-FA 1023
            |.:.|.....||::  :|.|||||: .:...|..:|:.:.|. .|:.:.|..:|........ |.
Zfish   144 GPVSRNAAEYLLSSGINGSFLVRES-ESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFN 207

  Fly  1024 SIQELIMHQYHSELPVTVKSGAI--LRRPVCR-------------ERWELSNDDVVLLERIGRGN 1073
            ::.||:.|  ||    ||..|.|  |..|..:             ::||:...|:.:..::|.|.
Zfish   208 TLAELVHH--HS----TVSDGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQ 266

  Fly  1074 FGDVYKAKLKSTKLDVAVKTCRM-TLPDEQKRKFLQEGRILKQYDHPNIVKLIGICVQKQPIMIV 1137
            :|:||:...|...|.|||||.:. |:..|:   ||:|..::|:..|||:|:|:|:|.::.|..|:
Zfish   267 YGEVYEGVWKKYSLTVAVKTLKEDTMEVEE---FLKEAAVMKEIKHPNLVQLLGVCTREPPFYII 328

  Fly  1138 MELVLGGSLLTYLRKNSNGLTTRQQMG------MCRDAAAGMRYLESKNCIHRDLAARNCLVDLE 1196
            .|.:..|:||.|||:     ..||::.      |....::.|.|||.||.||||||||||||...
Zfish   329 TEFMTHGNLLDYLRE-----CNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGEN 388

  Fly  1197 HSVKISDFGMSR--EEEEYIVSDGMKQIPVKWTAPEALNFGKYTSLCDVWSYGILMWEIFSKGDT 1259
            :.||::|||:||  ..:.|....|.| .|:||||||:|.:.|::...|||::|:|:|||.:.|.:
Zfish   389 NLVKVADFGLSRLMTGDTYTAHAGAK-FPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMS 452

  Fly  1260 PYSGMTNSRARERIDTGYRMPTPKSTPEEMYRLMLQCWAADAESRPHFDEIYNVVDAL 1317
            ||.|:..|:..|.::..|||..|:..||::|.||..||..:...||.|.|.:...:.:
Zfish   453 PYPGIDLSQVYELLEKDYRMDRPEGCPEKVYELMRACWRWNPAERPSFAETHQAFETM 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	25/89 (28%)
		TyrKc	1063..1311	CDD:197581	103/256 (40%)
		PTKc_Fes_like	1067..1315	CDD:270637	103/256 (40%)
abl1	XP_005172104.1	SH3_Abl	79..132	CDD:212784	8/56 (14%)
		SH2_ABL	137..230	CDD:198189	29/99 (29%)
		PTKc_Abl	249..511	CDD:270645	106/271 (39%)
		Pkinase_Tyr	256..507	CDD:285015	103/259 (40%)
		FABD	958..1081	CDD:197885
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810