DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment FER and pik3r3b

DIOPT Version :9

Sequence 1:	NP_524288.3	Gene:	FER / 41118	FlyBaseID:	FBgn0000723	Length:	1325	Species:	Drosophila melanogaster
Sequence 2:	XP_021332412.1	Gene:	pik3r3b / 100000252	ZFINID:	ZDB-GENE-040426-743	Length:	520	Species:	Danio rerio

Alignment Length:	397	Identity:	88/397 - (22%)
Similarity:	140/397 - (35%)	Gaps:	98/397 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   880 PPAGQKPVKPSVQISGHKDHPFESSSGELDENSDRDIDNDEEEEDSASDDVLSMKDHCYCVPSLA 944
            ||   ||.||...::|                      |..:|..|.|
Zfish    95 PP---KPTKPMTPVNG----------------------NGVKEAASGS----------------- 117

  Fly   945 ASISLSTNRPLYEEEWFHGVLPREEVVRLLNN--DGDFLVRETIRNEESQIVLSVCWNGHKHFIV 1007
                      |.|.||:.|.:.||||...|.:  ||.||||:.....:....|::...|:...|.
Zfish   118 ----------LQEAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIK 172

  Fly  1008 QTTGEGNFRFEGP-PFASIQELIMHQYHSEL-PVTVKSGAILRRPVCR-ERWELSNDDVVLLERI 1069
            ....:|.:.|..| .|.|:.|||.|..|..| ....|....|..||.| ::.:|..:|.:  :.:
Zfish   173 IYHRDGKYGFSDPLTFNSVVELISHYRHESLAQYNTKLDVKLMYPVSRYQQDQLVKEDNI--DAV 235

  Fly  1070 GR--GNFGDVYKAKLK----------STKLDVAVKTCRMTLPDEQKRKFLQEGRILKQYDHPNIV 1122
            ||  ..:.:.|:.|.|          .|..::.:|...:...:|..:.|.::....::|....|.
Zfish   236 GRKLQEYHNQYQEKSKEYDRLYEEHTKTSQEIQMKRTAIEAFNETIKIFEEQCHTQERYSKEYIE 300

  Fly  1123 KLIGICVQKQPIMIVMELVLGGSLLTYLRKNSNGLTTRQQMGMCRDAAAGMRYLESKNCIHRDL- 1186
            :.......|:...|:|......|.|..:..:.    ||.:..:...|.......:..|.:..||
Zfish   301 RFRREGNDKEIERIMMNYEKLKSRLGEIHDSK----TRLEQDLKTQALDNRETDKKMNSLKPDLI 361

  Fly  1187 ----AARNCLVDLEH----SVKISDF-GMSRE--EEEYIVSDGMKQIP----VKW-------TAP 1229
                .....||.|.|    ..:|:|: |:..|  ::.|.||:..:.:|    ..|       |..
Zfish   362 QLRKIRDQYLVWLNHKGVRQKRINDWLGLKNETTDDAYFVSEEDENLPHYDEKSWFVGDLNRTQS 426

  Fly  1230 EALNFGK 1236
            |.|..||
Zfish   427 EDLLHGK 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
FER	NP_524288.3	F-BAR_Fes_Fer	7..243	CDD:153341
		SH2_Fps_family	953..1039	CDD:198224	30/89 (34%)
		TyrKc	1063..1311	CDD:197581	40/209 (19%)
		PTKc_Fes_like	1067..1315	CDD:270637	40/205 (20%)
pik3r3b	XP_021332412.1	RhoGAP	<2..94	CDD:295372
		SH2_nSH2_p85_like	117..225	CDD:198195	36/134 (27%)
		iSH2_PIK3R3	230..390	CDD:214018	29/165 (18%)
		SH2_cSH2_p85_like	409..512	CDD:198184	7/25 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910