DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aduk and ULK2

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_016880913.1	Gene:	ULK2 / 9706	HGNCID:	13480	Length:	1057	Species:	Homo sapiens

Alignment Length:	291	Identity:	106/291 - (36%)
Similarity:	168/291 - (57%)	Gaps:	31/291 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 ITDFEILEK--LGAGSYATVYKARHKKQRTYH-AIKYVEMSTLSQTSRENLITEIRLLRELKHKY 67
            :.|||..::  :|.|::|.|::.||:::..:. |||.:....||: |:..|..||::|:||:|:.
Human     4 VGDFEYSKRDLVGHGAFAVVFRGRHRQKTDWEVAIKSINKKNLSK-SQILLGKEIKILKELQHEN 67

  Fly    68 IVTLQDFFWDDKNIYIVLEYCNAGNLSAF---------------------IRTKKALPESTCRYF 111
            ||.|.|......::::|:||||.|:|:.:                     :|.|..|.|.|.|.|
Human    68 IVALYDVQELPNSVFLVMEYCNGGDLADYLQGNCVCVSVFSKDSAAACLILRAKGTLSEDTIRVF 132

  Fly   112 LRQLAAAVQYMRANDVSHFDLKPQNLLLT---RGANNVS---LKVADFGFAQHLKLGEINQQLKG 170
            |.|:|||::.:.:..:.|.||||||:||:   |..::||   :|:||||||::|....:...|.|
Human   133 LHQIAAAMRILHSKGIIHRDLKPQNILLSYANRRKSSVSGIRIKIADFGFARYLHSNMMAATLCG 197

  Fly   171 SPLYMAPEIVRKHQYDAKADLWSIGVILYECLFGKAPYSSRTIEELLLRIRKAEAITLPPNARIS 235
            ||:|||||::....|||||||||||.::|:||.||.|:.:.:.::|.:...|..::........|
Human   198 SPMYMAPEVIMSQHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRSLMPSIPRETS 262

  Fly   236 NECHDLLRRLLAHEPTARISFADFFAHPFLD 266
            ....:||..||......|:.|..||:||||:
Human   263 PYLANLLLGLLQRNQKDRMDFEAFFSHPFLE 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	103/285 (36%)
		PKc_like	13..264	CDD:304357	100/280 (36%)
		MIT_2	274..348	CDD:239147
		MIT	407..472	CDD:282117
ULK2	XP_016880913.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.850