DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aduk and ATG1

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_011335.1	Gene:	ATG1 / 852695	SGDID:	S000003148	Length:	897	Species:	Saccharomyces cerevisiae

Alignment Length:	587	Identity:	161/587 - (27%)
Similarity:	269/587 - (45%)	Gaps:	123/587 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EKLGAGSYATVYKARHKKQRTYH-AIKYVEMSTL-SQTSRENLITEIRLLRELKHKYIVTLQDFF 75
            :::|.||:||||:......::.| |||.|..:.| ::...|||..||.:|:::||.:||.|.|..
Yeast    28 KEIGKGSFATVYRGHLTSDKSQHVAIKEVSRAKLKNKKLLENLEIEIAILKKIKHPHIVGLIDCE 92

  Fly    76 WDDKNIYIVLEYCNAGNLSAFIRTKKALPESTC-------RY-----------------FLRQLA 116
            ....:.|:::|||..|:|:..::.:|.|.|:..       :|                 :|:|||
Yeast    93 RTSTDFYLIMEYCALGDLTFLLKRRKELMENHPLLRTVFEKYPPPSENHNGLHRAFVLSYLQQLA 157

  Fly   117 AAVQYMRANDVSHFDLKPQNLLLTR-----------------GANNVS-LKVADFGFAQHLKLGE 163
            :|::::|:.::.|.|:|||||||:.                 |..|:. ||:||||||:.|....
Yeast   158 SALKFLRSKNLVHRDIKPQNLLLSTPLIGYHDSKSFHELGFVGIYNLPILKIADFGFARFLPNTS 222

  Fly   164 INQQLKGSPLYMAPEIVRKHQYDAKADLWSIGVILYECLFGKAPYSSRTIEELLLRIRKA-EAIT 227
            :.:.|.||||||||||:...:|:|||||||:|.:::|...|..|:.:....||..:|::| :.||
Yeast   223 LAETLCGSPLYMAPEILNYQKYNAKADLWSVGTVVFEMCCGTPPFRASNHLELFKKIKRANDVIT 287

  Fly   228 LPPNARISNECHDLLRRLLAHEPTARISFADFFAHPFL--DLKTFPTEHTLQKAIDLVTQACAYD 290
            .|....|..|..:|:..||..:|..||.|.:|||:..:  ||.::..|..|.   :|.:::....
Yeast   288 FPSYCNIEPELKELICSLLTFDPAQRIGFEEFFANKVVNEDLSSYELEDDLP---ELESKSKGIV 349

  Fly   291 EKHNYKEAYY---------------------------LYCSALQYFVPLITEETDATKRLALRNR 328
            |.:.:...|.                           |..|.:.....:.|:.|.|..:.|..|:
Yeast   350 ESNMFVSEYLSKQPKSPNSNLAGHQSMADNPAELSDALKNSNILTAPAVKTDHTQAVDKKASNNK 414

  Fly   329 ALS--YTKRAEEIKNCIIED---EYRMLAERQRQAATAATANQEPSSATQVPAAQPSSSRVAEML 388
            ..:  .:.|:.|.:..::|.   |...||:...||.......:.|:|      .|..:..:.|..
Yeast   415 YHNSLVSDRSFEREYVVVEKKSVEVNSLADEVAQAGFNPNPIKHPTS------TQNQNVLLNEQF 473

  Fly   389 EPDS-RYKQ--------LYALSNSSPSMKTGLEIGRKGELYLYERKLDAA----LESYTSALGI- 439
            .|:: :|.|        |.|.|:||    .|.:..|:..  |.:|:|..:    ..:.:.||||
Yeast   474 SPNNQQYFQNQGENPRLLRATSSSS----GGSDGSRRPS--LVDRRLSISSLNPSNALSRALGIA 532

  Fly   440 ---LVPFVNNEPKGER--------RNLLLQQLEFWMKEAESIKSILSAKHLDDEEQKLSTRTSLR 493
               |....|.:.:.::        :.||..||  :.:..|:|  ||...||...|......|::.
Yeast   533 STRLFGGANQQQQQQQITSSPPYSQTLLNSQL--FHELTENI--ILRIDHLQHPETLKLDNTNIV 593

  Fly   494 TI 495
            :|
Yeast   594 SI 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	103/296 (35%)
		PKc_like	13..264	CDD:304357	103/295 (35%)
		MIT_2	274..348	CDD:239147	14/105 (13%)
		MIT	407..472	CDD:282117	17/80 (21%)
ATG1	NP_011335.1	STKc_ATG1_ULK_like	30..324	CDD:270911	103/293 (35%)
ATG1	NP_011335.1	DUF3543	586..893	CDD:403327	2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344712
Domainoid	1	1.000	166	1.000	Domainoid score	I809
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003680
OrthoInspector	1	1.000	-	-		otm46828
orthoMCL	1	0.900	-	-		OOG6_101938
Panther	1	1.100	-	-	O	PTHR24348
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.770