DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Aduk and ULK1

DIOPT Version :9

Sequence 1:NP_731331.1 Gene:Aduk / 41112 FlyBaseID:FBgn0037679 Length:520 Species:Drosophila melanogaster
Sequence 2:XP_011537100.1 Gene:ULK1 / 8408 HGNCID:12558 Length:1073 Species:Homo sapiens


Alignment Length:269 Identity:109/269 - (40%)
Similarity:166/269 - (61%) Gaps:14/269 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 FEILEK--LGAGSYATVYKARHKKQRTYH-AIKYVEMSTLSQTSRENLITEIRLLRELKHKYIVT 70
            ||...|  :|.|::|.|:|.||:::.... |:|.:....|:: |:..|..||::|:||||:.||.
Human    14 FEFSRKDLIGHGAFAVVFKGRHREKHDLEVAVKCINKKNLAK-SQTLLGKEIKILKELKHENIVA 77

  Fly    71 LQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQ 135
            |.||.....::|:|:||||.|:|:.::...:.|.|.|.|.||:|:|.|::.:.:..:.|.|||||
Human    78 LYDFQEMANSVYLVMEYCNGGDLADYLHAMRTLSEDTIRLFLQQIAGAMRLLHSKGIIHRDLKPQ 142

  Fly   136 NLLLTRGA------NNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDAKADLWSI 194
            |:||:..|      |::.:|:||||||::|:...:...|.|||:|||||::....||.|||||||
Human   143 NILLSNPAGRRANPNSIRVKIADFGFARYLQSNMMAATLCGSPMYMAPEVIMSQHYDGKADLWSI 207

  Fly   195 GVILYECLFGKAPYSSRTIEELLLRIRKAEAI--TLPPNARISNECHDLLRRLLAHEPTARISFA 257
            |.|:|:||.||||:.:.:.::|.|...|.:.:  |:|  ...|.....||..||......|:.|.
Human   208 GTIVYQCLTGKAPFQASSPQDLRLFYEKNKTLVPTIP--RETSAPLRQLLLALLQRNHKDRMDFD 270

  Fly   258 DFFAHPFLD 266
            :||.|||||
Human   271 EFFHHPFLD 279

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AdukNP_731331.1 S_TKc 9..265 CDD:214567 106/266 (40%)
PKc_like 13..264 CDD:304357 103/261 (39%)
MIT_2 274..348 CDD:239147
MIT 407..472 CDD:282117
ULK1XP_011537100.1 STKc_ULK1 13..279 CDD:271104 107/267 (40%)
S_TKc 16..278 CDD:214567 104/264 (39%)
DUF3543 860..1067 CDD:288883
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0595
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1084750at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5656
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.850

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