DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aduk and Ulk3

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_082171.1	Gene:	Ulk3 / 71742	MGIID:	1918992	Length:	472	Species:	Mus musculus

Alignment Length:	499	Identity:	204/499 - (40%)
Similarity:	293/499 - (58%)	Gaps:	48/499 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LPRITDFEILEKLGAGSYATVYKARHKKQ-RTYHAIKYVEMSTLSQTSRENLITEIRLLRELKHK 66
            |||:..|.:.|:||:|:|||||||..||. |...|||.|...:|::.|.|||:|||.:|:.::|.
Mouse     8 LPRLDGFILTERLGSGTYATVYKAYAKKDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHP 72

  Fly    67 YIVTLQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFD 131
            :||.|:||.||:.|||:::|:|..|:||.||.|::.|||...|.|::|||:|:|::...::||.|
Mouse    73 HIVQLKDFQWDNDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLD 137

  Fly   132 LKPQNLLLTRGANNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDAKADLWSIGV 196
            |||||:||: ......||:||||||||:...:....|:|||||||||:|.:.||||:.||||:||
Mouse   138 LKPQNILLS-SLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVGV 201

  Fly   197 ILYECLFGKAPYSSRTIEELLLRIRKAEAITLPPNARISNECHDLLRRLLAHEPTARISFADFFA 261
            ||||.|||:.|::||:..||..:||....|.||...::|.:|.|||:|||..:|..||||.||||
Mouse   202 ILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPQLSLDCRDLLQRLLERDPARRISFKDFFA 266

  Fly   262 HPFLDLKTFPTEHTLQKAIDLVTQACAYDEKHNYKEAYYLYCSALQYFVPLITEETDATKRLALR 326
            ||::||:..|:..:|.:|..||.:|...|::.:...|..|||.||.:|||.:..|.||.::.|::
Mouse   267 HPWVDLEHMPSGESLAQARALVVEAVKKDQEGDAAAALSLYCKALDFFVPALHYEVDAQRKEAIK 331

  Fly   327 NRALSYTKRAEEIKNCIIEDEYRMLAERQRQAATAATANQEPSSATQVPAAQPSSSRVAEMLEPD 391
            .:...|..||||:|..:......:|    ||..|                       |.|:|...
Mouse   332 AKVGQYVSRAEELKAIVSSSNQALL----RQGTT-----------------------VQELLREM 369

  Fly   392 SRYKQ--LYALSNSSPSMKTGLEIGRKGELYLYERKLDAALESYTSALGILVPFVNNEPKGERRN 454
            :|.|.  |.||..:|.::....|.|::.:          ||:.|..:||.|:..:..|..|.||.
Mouse   370 ARDKPRLLAALEVASAALAKEEEAGKEQD----------ALDLYQHSLGELLVLLAAEAPGRRRE 424

  Fly   455 LLLQQLEFWMKEAESIK-------SILSAKHLDDEEQKLSTRTS 491
            ||..:::..|..||.:|       |...|:.||.|....|.|:|
Mouse   425 LLHTEVQNLMARAEYLKEQIKIRESHWEAESLDKEGLSESVRSS 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	134/256 (52%)
		PKc_like	13..264	CDD:304357	132/251 (53%)
		MIT_2	274..348	CDD:239147	25/73 (34%)
		MIT	407..472	CDD:282117	18/71 (25%)
Ulk3	NP_082171.1	S_TKc	14..270	CDD:214567	134/256 (52%)
		STKc_ULK3	18..269	CDD:271023	132/251 (53%)
		MIT_2	279..353	CDD:239147	25/73 (34%)
		MIT	374..449	CDD:239121	22/84 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842044
Domainoid	1	1.000	271	1.000	Domainoid score	I1814
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68482
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2313
Isobase	1	0.950	-	0	Normalized mean entropy	S2405
OMA	1	1.010	-	-		QHG45238
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	1	1.000	-	-		FOG0003680
OrthoInspector	1	1.000	-	-		oto93806
orthoMCL	1	0.900	-	-		OOG6_101938
Panther	1	1.100	-	-	LDO	PTHR24348
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	1	1.000	-	-		X6172
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	17	16.750