DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aduk and Ulk3

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001258064.1	Gene:	Ulk3 / 691171	RGDID:	1587417	Length:	472	Species:	Rattus norvegicus

Alignment Length:	499	Identity:	204/499 - (40%)
Similarity:	293/499 - (58%)	Gaps:	48/499 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LPRITDFEILEKLGAGSYATVYKARHKK-QRTYHAIKYVEMSTLSQTSRENLITEIRLLRELKHK 66
            |||:..|.:.|:||:|:|||||||..|| .|...|||.|...:|::.|.|||:|||.:|:.::|.
  Rat     8 LPRLDGFILTERLGSGTYATVYKAYAKKATREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHP 72

  Fly    67 YIVTLQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFD 131
            :||.|:||.||:.|||:::|:|..|:||.||.|::.|||...|.|::|||:|:|::...::||.|
  Rat    73 HIVQLKDFQWDNDNIYLIMEFCAGGDLSRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLD 137

  Fly   132 LKPQNLLLTRGANNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDAKADLWSIGV 196
            |||||:||: ......||:||||||||:...:....|:|||||||||:|.:.||||:.||||:||
  Rat   138 LKPQNILLS-SLEKPHLKLADFGFAQHMSPWDEKHVLRGSPLYMAPEMVCRRQYDARVDLWSVGV 201

  Fly   197 ILYECLFGKAPYSSRTIEELLLRIRKAEAITLPPNARISNECHDLLRRLLAHEPTARISFADFFA 261
            ||||.|||:.|::||:..||..:||....|.||...::|.:|.|||:|||..:|:.||||.||||
  Rat   202 ILYEALFGQPPFASRSFSELEEKIRSNRVIELPLRPQLSLDCRDLLQRLLERDPSHRISFQDFFA 266

  Fly   262 HPFLDLKTFPTEHTLQKAIDLVTQACAYDEKHNYKEAYYLYCSALQYFVPLITEETDATKRLALR 326
            ||::||:..|:..:|.:|..||.:|...|::.:...|..|||.||.:|||.:..|.||.::.|::
  Rat   267 HPWVDLEHMPSGESLAQATALVVEAVKKDQEGDAAAALSLYCKALDFFVPALHYEVDAQRKEAIK 331

  Fly   327 NRALSYTKRAEEIKNCIIEDEYRMLAERQRQAATAATANQEPSSATQVPAAQPSSSRVAEMLEPD 391
            .:...|..||||:|..:......:|    ||..|.                       .|:|...
  Rat   332 AKVGQYVSRAEELKAIVSSSNQALL----RQGTTG-----------------------QELLREM 369

  Fly   392 SRYKQ--LYALSNSSPSMKTGLEIGRKGELYLYERKLDAALESYTSALGILVPFVNNEPKGERRN 454
            :|.|.  |.||..:|.:|....|.|::.:          ||:.|..:||.|:..:..|..|.||.
  Rat   370 ARDKPRLLAALEVASAAMAKEEEAGKEQD----------ALDLYQHSLGELLLLLAAEAPGRRRE 424

  Fly   455 LLLQQLEFWMKEAESIK-------SILSAKHLDDEEQKLSTRTS 491
            ||..:::..|..||.:|       |...|:.||.|....|.|:|
  Rat   425 LLHTEVQNLMARAEYLKEQIKIRESHWEAESLDKEGLSESVRSS 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	134/256 (52%)
		PKc_like	13..264	CDD:304357	132/251 (53%)
		MIT_2	274..348	CDD:239147	25/73 (34%)
		MIT	407..472	CDD:282117	19/71 (27%)
Ulk3	NP_001258064.1	S_TKc	14..270	CDD:214567	134/256 (52%)
		STKc_ULK3	18..269	CDD:271023	132/251 (53%)
		MIT_2	279..353	CDD:239147	25/73 (34%)
		MIT	374..449	CDD:294211	23/84 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345445
Domainoid	1	1.000	271	1.000	Domainoid score	I1747
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68482
Inparanoid	1	1.050	344	1.000	Inparanoid score	I2263
OMA	1	1.010	-	-		QHG45238
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	1	1.000	-	-		FOG0003680
OrthoInspector	1	1.000	-	-		oto97345
orthoMCL	1	0.900	-	-		OOG6_101938
Panther	1	1.100	-	-	LDO	PTHR24348
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X6172
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770