DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aduk and Stk35

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_899085.3	Gene:	Stk35 / 67333	MGIID:	1914583	Length:	539	Species:	Mus musculus

Alignment Length:	365	Identity:	94/365 - (25%)
Similarity:	151/365 - (41%)	Gaps:	106/365 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LPRITDFEILEKLGAGSYATVYKARHKKQRTYHAIKYVEMSTLSQTSRENL---ITEIRLLRELK 64
            :|....:.:|.::|.|||..||:|...:.....|:|.:...     :.||:   :.|...|..||
Mouse   201 VPARPRYSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCD-----APENVELALAEFWALTSLK 260

  Fly    65 --HKYIVTLQD-----------FFWDDKN--------------------------IYIVLEYCNA 90
              |:.||..::           ....:||                          ::.|:|||..
Mouse   261 RRHQNIVQFEECVLQRNGLAQRMSHGNKNSQLYLRLVETSLKGERILGYAEEPCYLWFVMEYCEG 325

  Fly    91 GNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQNLLLTRGANNVSLKVADFGF 155
            |:|:.::.:::..| :|.:.|:.||.:|:.::..|.:.|.||||.|:|:|..:....|||||||.
Mouse   326 GDLNQYVLSRRPDP-ATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKVADFGL 389

  Fly   156 AQHLKLG------EINQQLK-------------GSPLYMAPEIVRKHQYDAKADLWSIGVILYEC 201
            :: :..|      |.||..|             ||..|||||:...| |.||||::::|:|::..
Mouse   390 SK-VCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGH-YTAKADIFALGIIIWAM 452

  Fly   202 LFGKAPYSSRTIEELL-LRIRKAEAITLPPNARISN---ECH--------------DLLRRLLAH 248
            :.......|.|.:||| ..|::...|.....|.:.|   |.|              .||:.:||.
Mouse   453 IERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGVKQLLKDMLAA 517

  Fly   249 EPTARISFADFFAHPFLDLKTFPTEHTLQKAIDLVTQACA 288
            .|..|                 |....|:..:|.||  ||
Mouse   518 NPQDR-----------------PDAFELETRMDQVT--CA 538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	86/334 (26%)
		PKc_like	13..264	CDD:304357	85/329 (26%)
		MIT_2	274..348	CDD:239147	6/15 (40%)
		MIT	407..472	CDD:282117
Stk35	NP_899085.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	103..161
		STKc_PDIK1L	206..534	CDD:270879	88/352 (25%)
		S_TKc	207..528	CDD:214567	87/345 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900