DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aduk and ulk1b

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	XP_002665971.2	Gene:	ulk1b / 558848	ZFINID:	ZDB-GENE-071203-2	Length:	1011	Species:	Danio rerio

Alignment Length:	290	Identity:	116/290 - (40%)
Similarity:	177/290 - (61%)	Gaps:	20/290 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FEILEK--LGAGSYATVYKARHKKQRTYH-AIKYVEMSTLSQTSRENLITEIRLLRELKHKYIVT 70
            ||...|  :|.|::|.|:|.||:::..:. |:|.:....|:: |:..|..||::|:||||:.||.
Zfish     7 FEFSRKDLIGHGAFAVVFKGRHREKHEWEVAVKCINKKNLAK-SQTLLGKEIKILKELKHENIVA 70

  Fly    71 LQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQ 135
            |.||.....::|:|:||||.|:|:.::.:|..|.|.|.|.||:|:..|::.::|..:.|.|||||
Zfish    71 LHDFQETASSVYLVMEYCNGGDLADYLHSKGTLSEDTIRVFLQQITGAMRVLQAKGIIHRDLKPQ 135

  Fly   136 NLLLTRGA------NNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDAKADLWSI 194
            |:||:..|      ||..:|:||||||::|:...:...|.|||:|||||::....||||||||||
Zfish   136 NILLSHPAGRKSHFNNTCIKIADFGFARYLQNNMMAATLCGSPMYMAPEVIMSQNYDAKADLWSI 200

  Fly   195 GVILYECLFGKAPYSSRTIEELLLRIRKAEAITLPPN--ARISNECHDLLRRLLAHEPTARISFA 257
            |.|:::||.||||:.:.:.::|.|...|.:  ||.||  ...|.....||..||......|:.|.
Zfish   201 GTIVFQCLTGKAPFQASSPQDLRLFYEKNK--TLSPNIPRETSTHLRHLLLGLLQRNHKDRMDFD 263

  Fly   258 DFFAHPFLDLKTFPTEHTLQKAIDLVTQAC 287
            :||.||||:..:     :::|:.. ||..|
Zfish   264 EFFRHPFLEASS-----SMKKSTP-VTVTC 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	110/266 (41%)
		PKc_like	13..264	CDD:304357	107/261 (41%)
		MIT_2	274..348	CDD:239147	4/14 (29%)
		MIT	407..472	CDD:282117
ulk1b	XP_002665971.2	PKc_like	6..272	CDD:304357	111/267 (42%)
		S_TKc	9..271	CDD:214567	108/264 (41%)
		DUF3543	796..1007	CDD:288883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.850