Protein Alignment Aduk and ULK3

DIOPT Version :10

• Sequence 1: NP_731331.1
• Gene: Aduk / 41112
• FlyBaseID: FBgn0037679
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001398011.1
• Gene: ULK3 / 25989
• HGNCID: 19703
• Length: 483
• Species: Homo sapiens
• Alignment Length: 472
• Identity: 192/472 - (40%)
• Similarity: 272/472 - (57%)
• Gaps: 47/472 - (9%)

  Fly    29 KKQRTYHAIKYVEMSTLSQTSRENLITEIRLLRELKHKYIVTLQDFFWDDKNIYIVLEYCNAGNL 93
            |..|...|||.|...:|::.|.|||:|||.:|:.::|.:||.|:||.||..|||:::|:|..|:|
Human    46 KDTREVVAIKCVAKKSLNKASVENLLTEIEILKGIRHPHIVQLKDFQWDSDNIYLIMEFCAGGDL 110

  Fly    94 SAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQNLLLTRGANNVSLKVADFGFAQH 158
            |.||.|::.|||...|.|::|||:|:|::...::||.||||||:||: ......||:||||||||
Human   111 SRFIHTRRILPEKVARVFMQQLASALQFLHERNISHLDLKPQNILLS-SLEKPHLKLADFGFAQH 174

  Fly   159 LKLGEINQQLKGSPLYMAPEIVRKHQYDAKADLWSIGVILYECLFGKAPYSSRTIEELLLRIRKA 223
            :...:....|:|||||||||:|.:.||||:.||||:||||||.|||:.|::||:..||..:||..
Human   175 MSPWDEKHVLRGSPLYMAPEMVCQRQYDARVDLWSMGVILYEALFGQPPFASRSFSELEEKIRSN 239

  Fly   224 EAITLPPNARISNECHDLLRRLLAHEPTARISFADFFAHPFLDLKTFPTEHTLQKAIDLVTQACA 288
            ..|.||....:|.:|.|||:|||..:|:.||||.||||||::||:..|:..:|.:|..||.||..
Human   240 RVIELPLRPLLSRDCRDLLQRLLERDPSRRISFQDFFAHPWVDLEHMPSGESLGRATALVVQAVK 304

  Fly   289 YDEKHNYKEAYYLYCSALQYFVPLITEETDATKRLALRNRALSYTKRAEEIKNCIIEDEYRMLAE 353
            .|::.:...|..|||.||.:|||.:..|.||.::.|::.:...|..||||:|..:
Human   305 KDQEGDSAAALSLYCKALDFFVPALHYEVDAQRKEAIKAKVGQYVSRAEELKAIV---------- 359

  Fly   354 RQRQAATAATANQEPSSATQVPAAQPSSSRVAEMLEPDSRYKQ--LYALSNSSPSMKTGLEIGRK 416
                           ||:.|....|.:|:|  ::|...:|.|.  |.||..:|.:|  ..|....
Human   360 ---------------SSSNQALLRQGTSAR--DLLREMARDKPRLLAALEVASAAM--AKEEAAG 405

  Fly   417 GELYLYERKLDAALESYTSALGILVPFVNNEPKGERRNLLLQQLEFWMKEAESIK-------SIL 474
            ||        ..||:.|..:||.|:..:..||.|.||.||..:::..|..||.:|       |..
Human   406 GE--------QDALDLYQHSLGELLLLLAAEPPGRRRELLHTEVQNLMARAEYLKEQVKMRESRW 462

  Fly   475 SAKHLDDEEQKLSTRTS 491
            .|..||.|....|.|:|
Human   463 EADTLDKEGLSESVRSS 479

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	Protein Kinases, catalytic domain	13..264	CDD:473864	120/234 (51%)
		MIT_2	274..348	CDD:239147	26/73 (36%)
		MIT	410..472	CDD:461228	20/68 (29%)
ULK3	NP_001398011.1	STKc_ULK3	46..280	CDD:271023	120/234 (51%)
		MIT_2	290..364	CDD:239147	28/98 (29%)
		MIT	385..460	CDD:469712	25/84 (30%)