DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Aduk and unc-51

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_507869.1	Gene:	unc-51 / 180311	WormBaseID:	WBGene00006786	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	510	Identity:	157/510 - (30%)
Similarity:	239/510 - (46%)	Gaps:	102/510 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FEILEK--LGAGSYATVYKARHKKQRTYH-AIKYVEMSTLSQTSRENLIT-EIRLLRE---LKHK 66
            ||..::  ||.|::|.||:.|:..:.... |||.:....:|::  :||:| ||::|:|   |||:
Worm     7 FEYSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKS--KNLLTKEIKILKELSSLKHE 69

  Fly    67 YIVTLQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFD 131
            .:|.|........::|:|:|:||.|:|:.:::.|..|.|.|.::|:.|:|.|::.:....:.|.|
Worm    70 NLVGLLKCTETPTHVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVVQIAHALEAINKKGIVHRD 134

  Fly   132 LKPQNLLLTRGA-------NNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDAKA 189
            |||||:||...:       .::.:|:||||||:.|..|.:...|.|||:|||||::...||||||
Worm   135 LKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSPMYMAPEVIMSMQYDAKA 199

  Fly   190 DLWSIGVILYECLFGKAPYSSRTIEELLLRIRKAEAI--TLP----PNARISNECHDLLRRLLAH 248
            ||||||.||::||.||||:.::|..:|.....|...:  .:|    ||.|      |||.|||..
Worm   200 DLWSIGTILFQCLTGKAPFVAQTPPQLKAYYEKTRELRPNIPEWCSPNLR------DLLLRLLKR 258

  Fly   249 EPTARISFADFFAHPFL--DLKTFPTEHTLQKAIDLVTQACAYDEKHNYKEAYYLYCSALQYFVP 311
            ....||||.|||.||||  .|...|::..|:.|..                             |
Worm   259 NAKDRISFEDFFNHPFLTSPLLPSPSKRILESARS-----------------------------P 294

  Fly   312 LITEETDATKRLALRNRALSYTKRAEEIKNCIIED--EYRMLAERQRQAATAATANQEPSSATQV 374
            |:     |.:|:.....:|...|||...|   ::.  ..|.:.|..|......|    |...:.|
Worm   295 LL-----ANRRIITPQSSLPVPKRAGSTK---LDSPTPVRRIGESPRVQRRVIT----PGMPSPV 347

  Fly   375 PAAQPSSSRVAEMLEP---DSRYKQLYALSNSSPSMKTGLEIGRKGELYLYERKLDAALESYTSA 436
            |.|....|.....|.|   .|..||:...:|.|||:.|...:....:...|: |::   |...:|
Worm   348 PGAPMQESTDFTFLPPRQESSPVKQVQVHTNVSPSLTTCKPVPVPSQRLTYQ-KME---ERLAAA 408

  Fly   437 LGILVPFVNNEPKGERRNLLLQQLEFWMKEAESIKSILSAKHLDDEEQKLSTRTS 491
            ....|| .::.|.|                     |.:||:|....:|:....:|
Worm   409 RKTAVP-SSSSPTG---------------------SAVSAQHQHQHQQQQEPASS 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	109/275 (40%)
		PKc_like	13..264	CDD:304357	106/270 (39%)
		MIT_2	274..348	CDD:239147	11/75 (15%)
		MIT	407..472	CDD:282117	9/64 (14%)
unc-51	NP_507869.1	S_TKc	9..275	CDD:214567	107/273 (39%)
		STKc_ULK1_2-like	15..274	CDD:271022	106/266 (40%)
		DUF3543	647..848	CDD:288883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5656
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.850