DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aduk and PDIK1L

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001230461.1	Gene:	PDIK1L / 149420	HGNCID:	18981	Length:	341	Species:	Homo sapiens

Alignment Length:	331	Identity:	74/331 - (22%)
Similarity:	143/331 - (43%)	Gaps:	83/331 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FEILEKLGAGSYATVYKARHKKQRTYHAIKYV-------------EMSTLSQTS---------RE 51
            ::::.::|.|||..||:|..:|.....|:|.:             |...||...         .|
Human     8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHAPENVELALREFWALSSIKSQHPNVIHLEE 72

  Fly    52 NLITEIRLLRELKH-----KYIVTLQ-----DFFWDDKNIY---IVLEYCNAGNLSAFIRTKKAL 103
            .::.:..:::::.|     .|:..::     :..:|.::.|   .|:::|:.|:::.::.::|.
Human    73 CILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGGDMNEYLLSRKP- 136

  Fly   104 PESTCRYFLRQLAAAVQYMRANDVSHFDLKPQNLLLTRGANNVS-----LKVADFGFAQHLKLGE 163
            ...|...|:.||::|:.::..|.:.|.||||.|:|:::...:.|     |||||||.::......
Human   137 NRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQTRLDTSDLEPTLKVADFGLSKVCSASG 201

  Fly   164 INQQ------------LKGSPLYMAPEIVRKHQYDAKADLWSIGVILYECLFGKAPYSSRTIEEL 216
            .|.:            ..|:..|||||:...| |.||||::::|:|::..|.......:.|.:||
Human   202 QNPEEPVSVNKCFLSTACGTDFYMAPEVWEGH-YTAKADIFALGIIIWAMLERITFIDTETKKEL 265

  Fly   217 -----------------LLRIRKAEAITLPPNARISNECHDLLRRLLAHEPTAR----------- 253
                             ||...|.|.:.......::.....|::.:||..|..|
Human   266 LGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSMNGRMKQLIKEMLAANPQDRPDAFELELRLV 330

  Fly   254 -ISFAD 258
             |:|.|
Human   331 QIAFKD 336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	74/331 (22%)
		PKc_like	13..264	CDD:304357	74/327 (23%)
		MIT_2	274..348	CDD:239147
		MIT	407..472	CDD:282117
PDIK1L	NP_001230461.1	STKc_PDIK1L	7..331	CDD:270879	71/324 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900