DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aduk and STK35

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_543026.2	Gene:	STK35 / 140901	HGNCID:	16254	Length:	534	Species:	Homo sapiens

Alignment Length:	370	Identity:	92/370 - (24%)
Similarity:	148/370 - (40%)	Gaps:	121/370 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PRITDFEILEKLGAGSYATVYKARHKKQRTYHAIKYVEMSTLSQTSRENL---ITEIRLLRELK- 64
            ||   :.:|.::|.|||..||:|...:.....|:|.:...     :.||:   :.|...|..||
Human   200 PR---YSLLAEIGRGSYGVVYEAVAGRSGARVAVKKIRCD-----APENVELALAEFWALTSLKR 256

  Fly    65 -HKYIVTLQD-------------------------------------------FFWDDKNIYIVL 85
             |:.:|..::                                           :.|      .|:
Human   257 RHQNVVQFEECVLQRNGLAQRMSHGNKSSQLYLRLVETSLKGERILGYAEEPCYLW------FVM 315

  Fly    86 EYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQNLLLTRGANNVSLKV 150
            |:|..|:|:.::.:::..| :|.:.|:.||.:|:.::..|.:.|.||||.|:|:|..:....|||
Human   316 EFCEGGDLNQYVLSRRPDP-ATNKSFMLQLTSAIAFLHKNHIVHRDLKPDNILITERSGTPILKV 379

  Fly   151 ADFGFAQHLKLG------EINQQLK-------------GSPLYMAPEIVRKHQYDAKADLWSIGV 196
            ||||.:: :..|      |.||..|             ||..|||||:...| |.||||::::|:
Human   380 ADFGLSK-VCAGLAPRGKEGNQDNKNVNVNKYWLSSACGSDFYMAPEVWEGH-YTAKADIFALGI 442

  Fly   197 ILYECLFGKAPYSSRTIEELL-LRIRKAEAITLPPNARISN---ECH--------------DLLR 243
            |::..:.......|.|.:||| ..|::...|.....|.:.|   |.|              .||:
Human   443 IIWAMIERITFIDSETKKELLGTYIKQGTEIVPVGEALLENPKMELHIPQKRRTSMSEGIKQLLK 507

  Fly   244 RLLAHEPTARISFADFFAHPFLDLKTFPTEHTLQKAIDLVTQACA 288
            .:||..|..|                 |....|:..:|.||  ||
Human   508 DMLAANPQDR-----------------PDAFELETRMDQVT--CA 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	83/340 (24%)
		PKc_like	13..264	CDD:304357	82/335 (24%)
		MIT_2	274..348	CDD:239147	6/15 (40%)
		MIT	407..472	CDD:282117
STK35	NP_543026.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	32..176
		STKc_PDIK1L	201..529	CDD:270879	86/361 (24%)
		S_TKc	202..523	CDD:214567	84/351 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900