DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aduk and ulk1a

DIOPT Version :9

Sequence 1:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001124103.1	Gene:	ulk1a / 100170793	ZFINID:	ZDB-GENE-080723-31	Length:	927	Species:	Danio rerio

Alignment Length:	504	Identity:	151/504 - (29%)
Similarity:	245/504 - (48%)	Gaps:	75/504 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 DFEILEKLGAGSYATVYKARHKKQRTYH-AIKYVEMSTLSQTSRENLITEIRLLRELKHKYIVTL 71
            :|...:.:|.|::|.|:|.|||::..:. |:|.:....|:: |:..|..||::|:||||:.||:|
Zfish     8 EFNRKDLIGHGAFAVVFKGRHKQKHNFEVAVKCINRKNLAK-SQSLLGKEIKILKELKHENIVSL 71

  Fly    72 QDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVSHFDLKPQN 136
            .||......:|:|:||||.|:|:.::.:|..|.|.|.|..|:|||.|:..:|:..:.|.||||||
Zfish    72 LDFQEISGCVYLVMEYCNGGDLAEYLHSKGCLSEDTIRVLLQQLAGAMSVLRSKGIIHRDLKPQN 136

  Fly   137 LLLT------RGANNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIVRKHQYDAKADLWSIG 195
            :||:      ...||:.:|:||||||::|:...:...|.|||:|||||::..|.|||||||||:|
Zfish   137 ILLSYSTGRKSNPNNICIKLADFGFARYLQGNTMAATLCGSPMYMAPEVIMSHNYDAKADLWSVG 201

  Fly   196 VILYECLFGKAPYSSRTIEELLLRIRKAEAITLPPNARISNECHDLLRRLLAHEPTARISFADFF 260
            .|:|:||.||||:.:.|.:||.....:..:::.......|:....||..||......||.|.|||
Zfish   202 TIIYQCLTGKAPFQASTPQELRQFYERNRSLSPSIPRETSSHLRHLLLGLLQRNQRERIDFDDFF 266

  Fly   261 AHPFLDLKTFPTEHTLQKA--IDLVTQACAYDEKHNYKEAYYLYCSALQYFVPLITEETDATKRL 323
            .||||:..|     :::|:  :.:......|....:   ..:...|:.....| ...:|:|.|.|
Zfish   267 HHPFLEAST-----SMKKSSPVPVPVPVPTYPSSGS---GSFSSGSSTSRLTP-TQSDTEAPKSL 322

  Fly   324 ALRNRALSYTKRAEEIKNCIIEDEYRMLAERQRQAATAATANQEPSSATQVPAAQPSSSRVAEML 388
            .        ..:..|....:::|                :::.:......|||...|....||
Zfish   323 P--------QMKPTESPGSLLKD----------------SSSSDSDDFVMVPAQFTSEPVGAE-- 361

  Fly   389 EPDSRYKQ----------LYALSNSSPSMKTGLEIGRKGELYLYERKLDAALESYTSALGILVPF 443
            ..||..:.          |....:||||.:|...         ..|.|::...||..::.:.||
Zfish   362 GQDSLMRSGSSLLGATACLCQTPSSSPSGRTSPR---------PSRHLESCGSSYAQSIPVPVP- 416

  Fly   444 VNNEPKGERRNLLLQQLEFWMKEAESIKSILSAKHLDDEEQKLSTRTSL 492
                  .::.|  .|::|..::|:|  ::..||.|...:......||.:
Zfish   417 ------TQKHN--YQRMEHNLQESE--RTSASAHHCCSDGSPACGRTGV 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	108/262 (41%)
		PKc_like	13..264	CDD:304357	106/257 (41%)
		MIT_2	274..348	CDD:239147	10/75 (13%)
		MIT	407..472	CDD:282117	12/64 (19%)
ulk1a	NP_001124103.1	STKc_ULK1	6..272	CDD:271104	109/264 (41%)
		S_TKc	9..271	CDD:214567	108/262 (41%)
		DUF3543	713..924	CDD:288883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0595
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1084750at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820