DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG16749 and PRSS53

DIOPT Version :9

Sequence 1:	NP_649881.1	Gene:	CG16749 / 41111	FlyBaseID:	FBgn0037678	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	XP_011544118.1	Gene:	PRSS53 / 339105	HGNCID:	34407	Length:	623	Species:	Homo sapiens

Alignment Length:	296	Identity:	73/296 - (24%)
Similarity:	115/296 - (38%)	Gaps:	79/296 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 PQMGRVVNGTDSSVEKYPFVISMRGSSGSHSCGGSIISKQFVMTAAHCTDGRKASDL---SVQYG 86
            ||.|..|.|      ::|:..|:| ..|:|.|.||:::..:|:|||||.:...|::|   ||..|
Human    38 PQEGNTVPG------EWPWQASVR-RQGAHICSGSLVADTWVLTAAHCFEKAAATELNSWSVVLG 95

  Fly    87 VTKINATGPNV--VRVKKIIQHEDYNPYNNYANDISLLLVEEPFEFDGVTVAPVKLPELAFATPQ 149
            ..:.....|..  |.|..:.....||.|:. .:|::||.:..|     .|..|:.||:.|...|
Human    96 SLQREGLSPGAEEVGVAALQLPRAYNHYSQ-GSDLALLQLAHP-----TTHTPLCLPQPAHRFP- 153

  Fly   150 TDAGGEGVLIGWGLNATGGY-------------------------IQS----------------- 172
              .|......||..:.:.|.                         .||
Human   154 --FGASCWATGWDQDTSDGKCWPRLKLGEALCLPSVTVSAPNCPGFQSPLLPRSQTLAPAPSLSP 216

  Fly   173 ---TLQEVELKVYSDEECT-------ERHGGRTDPRYHICGGVDEGGKGQCSGDSGGPLIY---N 224
               ||:.:.|::.|...|.       :||.........:|||...|.:|.|.||||||::.   :
Human   217 APGTLRNLRLRLISRPTCNCIYNQLHQRHLSNPARPGMLCGGPQPGVQGPCQGDSGGPVLCLEPD 281

  Fly   225 GQ--QVGIVSWSIKPCTVAPYPGVYCKVSQYVDWIK 258
            |.  |.||:|:: ..|.....|.:....:.:..|::
Human   282 GHWVQAGIISFA-SSCAQEDAPVLLTNTAAHSSWLQ 316

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG16749	NP_649881.1	Tryp_SPc	29..257	CDD:214473	69/289 (24%)
CG16749	NP_649881.1	Tryp_SPc	30..259	CDD:238113	70/291 (24%)
PRSS53	XP_011544118.1	Tryp_SPc	42..316	CDD:238113	70/290 (24%)
		Tryp_SPc	43..314	CDD:214473	69/287 (24%)
		Tryp_SPc	359..>512	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24276
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100