DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12951 and TMPRSS5

DIOPT Version :9

Sequence 1:	NP_649880.1	Gene:	CG12951 / 41110	FlyBaseID:	FBgn0037677	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_110397.2	Gene:	TMPRSS5 / 80975	HGNCID:	14908	Length:	457	Species:	Homo sapiens

Alignment Length:	260	Identity:	84/260 - (32%)
Similarity:	138/260 - (53%)	Gaps:	26/260 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IVILAVTTVGQAAPSISRVVNGTDSSVLKYPFVVSLRSYDGSHSCGGSIISKHFVMTAAHCTNGR 76
            :|.|..:..| |.|..||:|.|...:..::|:..|: :....|:||||:::..:|:|||||.:..
Human   201 VVSLRCSECG-ARPLASRIVGGQSVAPGRWPWQASV-ALGFRHTCGGSVLAPRWVVTAAHCMHSF 263

  Fly    77 PADTLS---IQFGVTNISAMGPNVVG-IKKIIQHEDFDPTRQNAN-DISLLMVEEPFEFDGVSVA 136
            ....||   :..|:.:.||:.|:... :::||.|..:  :.||.: |::||.::....|.. :|.
Human   264 RLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLY--SAQNHDYDVALLRLQTALNFSD-TVG 325

  Fly   137 PVELPALAFAVPQSDAGVEGVLIGWG---LNDTYGSVQDTLQEVSLKIYSDEECTSR--HNGQTD 196
            .|.|||.....|:   |....:.|||   .:.||.|  |.||:..:.::|.:.|.|.  ::|...
Human   326 AVCLPAKEQHFPK---GSRCWVSGWGHTHPSHTYSS--DMLQDTVVPLFSTQLCNSSCVYSGALT 385

  Fly   197 PKYHICGGVDEGGKGQCSGDSGGPLIY----NGQQVGIVSWSIKPCTVAPYPGVYCKVSQYVDWI 257
            |:. :|.|..:|....|.|||||||:.    ..:.||:|||. :.|....:||||.||::::|||
Human   386 PRM-LCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWG-RGCAEPNHPGVYAKVAEFLDWI 448

Fly 258 257
Human 449 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12951	NP_649880.1	Tryp_SPc	29..257	CDD:214473	76/241 (32%)
CG12951	NP_649880.1	Tryp_SPc	30..260	CDD:238113	77/242 (32%)
TMPRSS5	NP_110397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		SRCR_2	116..213	CDD:292133	4/12 (33%)
		Tryp_SPc	217..448	CDD:214473	76/241 (32%)
		Tryp_SPc	218..451	CDD:238113	77/242 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920