Protein Alignment CG12951 and TMPRSS7

DIOPT Version :10

• Sequence 1: NP_649880.1
• Gene: CG12951 / 41110
• FlyBaseID: FBgn0037677
• Length: 265
• Species: Drosophila melanogaster
• Sequence 2: NP_001382436.1
• Gene: TMPRSS7 / 344805
• HGNCID: 30846
• Length: 843
• Species: Homo sapiens
• Alignment Length: 1033
• Identity: 185/1033 - (17%)
• Similarity: 306/1033 - (29%)
• Gaps: 358/1033 - (34%)

  Fly    37 IFPGEKRVS---LSPNGVALL---KKNGISVLIEENAGVLAGYSNEEYVRSGADVGKHNEVFNTD 95
            |..|..||:   |..|.|.|:   ||..|..|:.....:      ...||....:|.
Human   641 IADGRLRVNDWLLRINDVDLINKDKKQAIKALLNGEGAI------NMVVRRRKSLGG-------- 691

  Fly    96 IMLKVRPPTENEVSKLK-SGCTLISFIH-----PGQNQALLDSLTKTDKTV----FAMD------ 144
               ||..|....:|..| ||.:|.:.::     ||...|...||...|:.|    .|:|
Human   692 ---KVVTPLHINLSGQKDSGISLENGVYAAAVVPGSPAAKEGSLAVGDRIVAINGIALDNKSLNE 753

  Fly   145 CVPRISRAQVFDALSSMANIAGYRAVIEAANHFGRFFTGQITAAGKVPPAKVLVIGGGVAGLSAI 209
            |...:...|  |:|:    ::..:...::::..|:.....|..:.::              ||.
Human   754 CESLLRSCQ--DSLT----LSLLKVFPQSSSWSGQNIFENIKDSDRM--------------LSC- 797

  Fly   210 GTSRGMGAVVRGFDTRAAVKEHVESLGAQFLTVNVKEDGEGG--GGYAKEMSKEFIDAEMKLFAD 272
               |..|..|:..:.|..::.:..:....|.|..:::..|.|  ||.:..:.|.|..:...:...
Human   798 ---RAHGPEVQAHNKRNLLQHNNSTQTDIFYTDRLEDRKELGHSGGSSSFLHKPFSGSSSPVSPQ 859

  Fly   273 QCKD---------------------VDIIITTALIPGKKAPILITEEMIKSMKPGSVVVDLAAES 316
            .|..                     ||:        ..:.|:|..|..:.......|.:|.....
Human   860 ACPSTSERSLNSFRSDTSAERGYGLVDM--------RSQRPLLSFETEVGPCGAVEVPLDKIDPE 916

  Fly   317 GGNIATTRPGEVYVKHGVTHIGFTDLPSRL-----PTQSSELYSNNIAKFLLHLGKDKTFFVNEE 376
            |.|...|.|..|        :|.|..|.:|     |.|...::..|..|      :.:|
Human   917 GSNSGGTWPKAV--------LGSTSGPEKLSVYKKPKQRKSIFDPNTFK------RPQT------ 961

  Fly   377 DEVARGALVVRDGQMKWPPPPINF--PPPAAPKSDKPSENT-ALVPLTPFRKTAN---QTLLLTS 435
                              ||.|::  |.|....|.:||:.. :|.|..|.|::.:   |..|.||
Human   962 ------------------PPKIDYLLPGPGLTHSPQPSKRVGSLTPPKPPRRSDSIKFQHRLETS 1008

  Fly   436 GLGSVSLLGIAGTNPQISSMSTTFALAGLVGYHTVWGVTPALHSPLMSVTNAISGTTAAGALCLM 500
            .....:|:|        ||.||:               .|:...|.|..:.....:....|...:
Human  1009 SESEATLVG--------SSPSTS---------------PPSAPPPSMDPSEPTHASPPRKARVRI 1050

  Fly   501 GGGLMPQNSAQTMALLATFISSVNIGGGFLVTKRMLDMFKRKDDPPEHNYLFS-------IPAAV 558
            ......:....|..|.|......::      |.:.:|...:|...|:....|.       |||.
Human  1051 ASSYHSEGDGDTSYLPAKKPCDEDL------TSQKVDELGQKRRRPKSAPSFRPKISPVVIPAQ- 1108

  Fly   559 FLGGYGYGVYTAAPLIHSYAYLGSSLC-----CVGALAGLSSQS----------TARVGNALGII 608
                                      |     ||.|:..||.:.          .:|.||.
Human  1109 --------------------------CLEEQECVPAIGELSPEGQEWSPYSPGHASRHGNP---- 1143

  Fly   609 GVTGGIGATLGLLQPDFNTLCQMGGSVAMGSLIGLGIANRIKVTDLPQLVAAFHSFVGLAATLTC 673
                       ||.|:..::..:..|:..|:.:|..:.|.|......:::......|...|....
Human  1144 -----------LLYPNRPSVGTVPRSMTPGTTVGSILRNPIYTVRSHRVLPCGSPPVPRDAGSQS 1197

  Fly   674 LANFIQEHPHFLEDPSNAAAAKLALFLGTYIGGVTFTGSLMAYGKLQGILASAPTYLPARHVLNG 738
            |:..:|.......|.|:.|.:.                    |.:::.  :.....||:
Human  1198 LSPSVQHQGRLSLDLSHRACSD--------------------YSEMRA--SQGSNSLPS------ 1234

  Fly   739 ALLAGNVGALGTYMYSTDFGTGMSMLGGTVGLSSLMGVTLTMAIGGADMPIVITVLNSYSGWALC 803
                                            |:.:|.:..:......:.|.:|.....|
Human  1235 --------------------------------SARLGSSSNLQFKAERIKIPLTPRYPRS----- 1262

  Fly   804 AEGFMLDNSLLTVLGALIGSSGAILSHIMCKAMNRSLLNVILGGVGTKSKGTGEAKAIEGTAKEI 868
                            ::||....|||..|....||.||                  |:..:...
Human  1263 ----------------VMGSDRGSLSHSECSTPPRSPLN------------------IDTLSSCS 1293

  Fly   869 APVETADMLLNARSVIIIPGYGLCAAQAQYPIAQLVKELQQRGVRVRFAIHP-----VAGRMPG- 927
            .|..||..|  .|..:....:|  ..:...|..:     :.|.|:|:....|     |:|...|
Human  1294 QPQTTASTL--PRIAVNPSSHG--ERRKDRPFVE-----EPRHVKVQKGSEPLGISIVSGEKGGV 1349

  Fly   928 -----QLNVLLAEAGVPY-DIVEEMEEIN-EDFKETDVALVIGSN-DTINSAAEDDPN 977
                 .|..:..:||:.| |.:.|...|| ....|....|:||.. |||...|:.:|:
Human  1350 YVSKVTLGSIAHQAGLEYGDQLLEFNGINLRSATEQQARLIIGQQCDTITILAQYNPH 1407

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12951	NP_649880.1	Tryp_SPc	30..260	CDD:238113	50/246 (20%)
TMPRSS7	NP_001382436.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	27..67
		SEA	108..207	CDD:460188
		CUB	247..359	CDD:238001
		LDLa	484..518	CDD:238060
		LDLa	559..594	CDD:238060
		Tryp_SPc	605..835	CDD:214473	46/234 (20%)