DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12951 and TMPRSS7

DIOPT Version :9

Sequence 1:	NP_649880.1	Gene:	CG12951 / 41110	FlyBaseID:	FBgn0037677	Length:	265	Species:	Drosophila melanogaster
Sequence 2:	NP_001382436.1	Gene:	TMPRSS7 / 344805	HGNCID:	30846	Length:	843	Species:	Homo sapiens

Alignment Length:	274	Identity:	75/274 - (27%)
Similarity:	129/274 - (47%)	Gaps:	68/274 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 TVGQAAPSISRVVNGTDSSVLKYPFVVSLRSYDGSHSCGGSIISKHFVMTAAHCTNG-RPADTL- 81
            |..:::.::.|::.|||:....:|:.|||. :.||..||.|:||:.::::||||.:| |.:|..
Human   595 TCSRSSSALHRIIGGTDTLEGGWPWQVSLH-FVGSAYCGASVISREWLLSAAHCFHGNRLSDPTP 658

  Fly    82 -SIQFGV---TNISAMGPNVVGIKKIIQHEDFDPTRQNANDISLLMVEEPFEFDGVSVAPVELPA 142
             :...|:   .|...:.|    :::|:.||.::              .:.|::|      :.|..
Human   659 WTAHLGMYVQGNAKFVSP----VRRIVVHEYYN--------------SQTFDYD------IALLQ 699

  Fly   143 LAFAVPQS-----------------DAGVEGVLIGWGLN---DTYGSVQDTLQEVSLKIYSDEEC 187
            |:.|.|::                 .:|.:..:.|||..   |..||:  .||:..:::.....|
Human   700 LSIAWPETLKQLIQPICIPPTGQRVRSGEKCWVTGWGRRHEADNKGSL--VLQQAEVELIDQTLC 762

  Fly   188 TSRHNGQTDPKYHICGGVDEGGKGQCSGDSGGPLI----YNGQQV--GIVSW---SIKPCTVAPY 243
            .|.:...|...  :|.|:..|.:..|.|||||||.    .:|:.:  |||||   |.:|    .:
Human   763 VSTYGIITSRM--LCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRP----NF 821

  Fly   244 PGVYCKVSQYVDWI 257
            ||||.:||.:|.||
Human   822 PGVYTRVSNFVPWI 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12951	NP_649880.1	Tryp_SPc	29..257	CDD:214473	72/262 (27%)
CG12951	NP_649880.1	Tryp_SPc	30..260	CDD:238113	73/263 (28%)
TMPRSS7	NP_001382436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..67
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D433637at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920